Patient reported outcome in HFpEF: Sex-specific differences in quality of life and association with outcome

Faxén, Ulrika Ljung; Hage, Camilla; Donal, Erwan; Daubert, Jean‐Claude; Linde, Cecilia; Lund, Lars H.

doi:10.1016/j.ijcard.2018.04.102

Cited by 31 publications

(44 citation statements)

References 30 publications

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“…This may explain the comparable to lower risk of adverse events such as hospitalization and mortality among women vs. men in prior studies . Heart failure‐specific quality of life was not different across sexes in the RELAX trial, which is consistent with some prior reports and may be related to the small sample size …”

Section: Baseline Characteristics Of Women and Men With Chronic Heartsupporting

confidence: 85%

“…While the lifetime risk of heart failure with preserved ejection fraction (HFpEF) is comparable across sexes, its prevalence is higher in women . Women with HFpEF have worse patient‐reported outcomes but lower risk of adverse cardiovascular events . The mechanisms underlying these sex differences in HFpEF are not well established.…”

Section: Baseline Characteristics Of Women and Men With Chronic Heartmentioning

confidence: 99%

“…Prior studies have demonstrated that women with HFpEF have worse patient‐reported outcomes and lower overall quality of life . These sex differences in patient‐reported outcomes may be related to lower exercise capacity, with up to 18% lower VO 2Peak in women (vs. men).…”

Section: Baseline Characteristics Of Women and Men With Chronic Heartmentioning

confidence: 99%

“…2 Women with HFpEF have worse patient-reported outcomes but lower risk of adverse cardiovascular events. 3,4 The mechanisms underlying these sex differences in HFpEF are not well established. Accordingly, we evaluated the sex differences in the burden of myocardial injury, stress, fibrosis, and inflammation, and their contribution toward exercise capacity among patients with HFpEF.…”

Section: Sex Differences In Cardiac Function Biomarkers and Exercisementioning

confidence: 99%

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Sex differences in cardiac function, biomarkers and exercise performance in heart failure with preserved ejection fraction: findings from the RELAX trial

Mauricio

Patel

Agusala

et al. 2019

European J of Heart Fail

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Section: Baseline Characteristics Of Women and Men With Chronic Heartsupporting

confidence: 85%

Section: Baseline Characteristics Of Women and Men With Chronic Heartmentioning

confidence: 99%

Section: Baseline Characteristics Of Women and Men With Chronic Heartmentioning

confidence: 99%

Section: Sex Differences In Cardiac Function Biomarkers and Exercisementioning

confidence: 99%

See 2 more Smart Citations

Sex differences in cardiac function, biomarkers and exercise performance in heart failure with preserved ejection fraction: findings from the RELAX trial

Mauricio

Patel

Agusala

et al. 2019

European J of Heart Fail

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“…The poorer self‐efficacy in women could impact negatively on the self‐care of both chronic diseases (HF and DM). Indeed, this was echoed in other studies, where women reported lower QoL scores than men . Interestingly, QoL was not as strongly associated with HF in women, suggesting involvement of other coexisting factors …”

Section: Discussionmentioning

confidence: 69%

Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN‐HF registry

Chandramouli

Teng

Tay

et al. 2018

European J of Heart Fail

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Aims To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1‐year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM). Methods and results Utilizing the Asian Sudden Cardiac Death in HF (ASIAN‐HF) registry, 5255 patients (mean age 59.6 ± 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were stratified by DM status to address the research aims. Despite similar prevalence of DM between Asian men (43%) and women (42%), the odds of DM increased at lower body mass index in women vs. men (≥ 23 vs. ≥ 27.5 kg/m2, Pinteraction = 0.014). DM was more strongly related to chronic kidney disease in women vs. men [adjusted odds ratio (OR) 1.85, 95% confidence interval (CI) 1.33–2.57 vs. OR 1.32, 95% CI 1.11–1.56, Pinteraction = 0.009]. Sex also modified the relationship between DM and left ventricular geometry (Pinteraction = 0.003), whereby DM was associated with a more concentric left ventricular geometry in women than men. Women had lower quality of life than men (P < 0.001), in both DM and non‐DM groups. DM was associated with worse composite outcomes at 1 year in women vs. men [hazard ratio (HR) 1.79, 95% CI 1.24–2.60 vs. HR 1.32, 95% CI 1.12–1.56; Pinteraction = 0.005). Conclusions Asian women with HFrEF were more likely to have DM despite a lean body mass index, a greater burden of chronic kidney disease and more concentric left ventricular geometry, compared to men. Furthermore, DM confers worse quality of life, irrespective of sex, and a greater risk of adverse outcomes in women than men. These data underscore the need for sex‐specific approaches to diabetes in patients with HF.

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Baseline characteristics of 547 new onset heart failure patients in the PREFERS heart failure study

et al. 2022

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AimWe present the baseline characteristics of the PREFERS Stockholm epidemiological study on the natural history and course of new onset heart failure (HF) aiming to improve phenotyping focusing on HF with preserved left ventricular ejection fraction (HFpEF) pathophysiology. Methods and resultsNew onset HF patients diagnosed in hospital or at outpatient HF clinics were included at five Stockholm hospitals 2015-2018 and characterized by N-terminal pro brain natriuretic peptide (NT-proBNP), biomarkers, echocardiography, and cardiac magnetic resonance imaging (subset). HFpEF [left ventricular ejection fraction (LVEF) ≥ 50%] was compared with HF with mildly reduced LVEF (HFmrEF; LVEF 41-49%) and with HF with reduced LVEF (HFrEF; LVEF ≤ 40%). We included 547 patients whereof HFpEF (n = 137; 25%), HFmrEF (n = 61; 11%), and HFrEF (n = 349; 64%). HFpEF patients were older (76; 70-81 years; median; interquartile range) than HFrEF (67; 58-74; P < 0.001), more often women (49% vs. 30%; P < 0.001), and had significantly higher comorbidity burden. They more often had atrial fibrillation, hypertension, and renal dysfunction. NT-proBNP was lower in HFpEF (896; 462-1645 ng/L) than in HFrEF (1160; 563-2370; P = 0.005). In HFpEF, left ventricular (LV) diameters and volumes were smaller (P < 0.001) and septal and posterior wall thickness and relative wall thickness higher (P < 0.001). E/é ≥ 14 was present in 26% of HFpEF vs. 32% of HFrEF (P = 0.017) and left atrial volume index > 34 mL/m 2 in 57% vs. 61% (P = 0.040). HFmrEF patients were intermediary between HFpEF and HFrEF for LV mass, LV volumes, and RV volumes but had the highest proportion of left ventricular hypertrophy and the lowest proportion of elevated E/é. Conclusions Phenotype data in new onset HF patients recruited in a broad clinical setting showed that 25% had HFpEF, were older, more often women, and had greater comorbidity burden. PREFERS is well suited to further explore biomarker and imaging components of HFpEF pathophysiology and may contribute to the emerging knowledge of HF epidemiology. Clinical trial registration: Clinicaltrials.gov identifier: NCT03671122.

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Patient reported outcome in HFpEF: Sex-specific differences in quality of life and association with outcome

Cited by 31 publications

References 30 publications

Sex differences in cardiac function, biomarkers and exercise performance in heart failure with preserved ejection fraction: findings from the RELAX trial

Sex differences in cardiac function, biomarkers and exercise performance in heart failure with preserved ejection fraction: findings from the RELAX trial

Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN‐HF registry

Baseline characteristics of 547 new onset heart failure patients in the PREFERS heart failure study

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