Patient-reported health problems and healthcare use after treatment for early-stage breast cancer

Ligt, K.M. de; Heins, M.; Verloop, Janneke; Smorenburg, Carolien H.; Korevaar, Joke C.; Siesling, Sabine

doi:10.1016/j.breast.2019.03.010

Cited by 28 publications

(27 citation statements)

References 32 publications

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“…These findings reflect that survivors are still suffering from their diagnosis of advanced melanoma and the treatment trajectory. Previously, physical, psychosocial, and cognitive problems have been reported and associated with reduced HRQoL levels in cancer survivor populations [32][33][34]. In this study, 61% received systemic non-ICI treatment and almost all survivors had surgery prior to ipilimumab.…”

Section: Discussionmentioning

confidence: 74%

Health-related quality of life of long-term advanced melanoma survivors treated with anti-CTLA-4 immune checkpoint inhibition compared to matched controls

et al. 2020

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Section: Discussionmentioning

confidence: 74%

Health-related quality of life of long-term advanced melanoma survivors treated with anti-CTLA-4 immune checkpoint inhibition compared to matched controls

et al. 2020

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“…Patient-Reported Outcome Measures (PROMs) are suggested as symptom detection method [21, 23], but implementation in daily practice is hampered [21, 24, 25]. Furthermore, support in coping with symptoms may be insufficient, as patient-reported health symptoms consistently over time (years) after diagnosis [9, 11, 26, 27]. Wu et al describe that 92% of patient-reported residual symptoms 1 year after diagnosis, and 61% reporting pain, fatigue, and sleep disturbance up to 5 years after diagnosis [27].…”

Section: Introductionmentioning

confidence: 99%

The impact of health symptoms on health-related quality of life in early-stage breast cancer survivors

Ligt

Heins

Verloop

et al. 2019

Breast Cancer Res Treat

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PurposeIn breast cancer patients, treatment-related health symptoms can occur that may affect their health-related quality of life (HRQoL). This study aimed to determine the impact of health symptoms on HRQoL in breast cancer patients up to 5 years after diagnosis.MethodsFemales surgically treated for early-stage breast cancer diagnosed between 2012 and 2016 (n = 876) were selected from the Netherlands Cancer Registry and invited for a survey about current health symptoms (‘Symptoms and Perceptions questionnaire’, SaP) and HRQoL (‘EORTC-QLQ-C30’). From the latter, functioning and global health were included. Mean scores were compared to norm population scores (T test). Multivariable linear regression analyses were performed to determine the association between health symptoms and global health and functioning.Results404 patients (46%) responded. The median age was 62.2 ± 10.9 years. Respondents had significantly lower mean scores for role, cognitive, emotional, and social functioning than the general population. The most frequently reported health symptoms were musculoskeletal (including pain/complaints in lower/upper extremities/back/neck; 71%) and central nervous system symptoms (including concentration impairment, dizziness, neuralgia; 66%), and fatigue (63%). While most symptoms affected functioning, irrespective of time since diagnosis, especially fatigue, musculoskeletal, central nervous system, and gastrointestinal symptoms were significantly associated (p < 0.05) with lower functioning.ConclusionsThe majority of health symptoms that occur after breast cancer treatment were associated with lower functioning of patients in daily life. This paper urges healthcare providers to support breast cancer patients in alleviating or coping with health symptoms, even years after end of treatment, to improve their functioning.Electronic supplementary materialThe online version of this article (10.1007/s10549-019-05433-3) contains supplementary material, which is available to authorized users.

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“…Even though treatment protocols are currently less aggressive, it was found in literature that declines after breast cancer diagnosis can be associated with chemotherapy and surgery treatments 7 . It is important to highlight that most patients in the present study were undergoing chemo- therapy treatment, and had undergone mastectomy for breast cancer, which can worsen the fatigue perception in more severe degrees 5 . This study showed that women undergoing physiotherapy reported significantly higher levels of fatigue when compared to those who were not and were more likely of having mild to severe fatigue.…”

Section: Discussionmentioning

confidence: 99%

“…When submitted to treatment, women may suffer physical, psychological, emotional or social consequences 5 . Fatigue, defined as an unpleasant physical sensation, with symptoms of extreme tiredness and exhaustion, is considered one of the most prevalent consequences in cancer patients, severely impacting quality of life, decreasing daily functional capacity 6 .…”

Section: Introductionmentioning

confidence: 99%

Relationship of fatigue with depressive symptoms and level of physical activity in women with breast cancer diagnosis

Matoso

Boing

Korpalski

et al. 2020

Rev. bras. cineantropom. desempenho hum.

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Breast cancer is the most frequent in women, resulting in fatigue and depressive symptoms as consequence of treatment, but physical activity can help in this process. The aim of this study was to investigate the relationship between fatigue, depressive symptoms and practice of physical activity of women with breast cancer during treatment or after cancer treatment. This is a cross-sectional study with 179 women (56.89 ± 9.4 years) from the Oncology Research Center - CEPON, using questionnaire on general and clinical information, fatigue (Piper Fatigue Scale) depressive symptoms (Beck Depression Inventory) and physical activity (IPAQ - short version). Women with moderate to severe fatigue underwent physiotherapy (p = 0.001) and women with no fatigue had minimum depressive symptoms (p ?0.001). Level of physical activity was not associated with fatigue, with most women being insufficiently active and women with mild fatigue had longer walking time than those without fatigue (p = 0.049). Women with depressive symptoms were almost three times more likely of having mild to severe fatigue and those who underwent physiotherapy were twice as likely of having mild to severe fatigue. Women with fatigue had greater presence of depressive symptoms. Professionals working in the field of oncology should recommend the practice of physical activity in order to minimize the side effects of treatment and observe depressive symptoms and fatigue in these women.

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Patient-reported health problems and healthcare use after treatment for early-stage breast cancer

Cited by 28 publications

References 32 publications

Health-related quality of life of long-term advanced melanoma survivors treated with anti-CTLA-4 immune checkpoint inhibition compared to matched controls

Health-related quality of life of long-term advanced melanoma survivors treated with anti-CTLA-4 immune checkpoint inhibition compared to matched controls

The impact of health symptoms on health-related quality of life in early-stage breast cancer survivors

Relationship of fatigue with depressive symptoms and level of physical activity in women with breast cancer diagnosis

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