Patient reported health outcomes and non-adherence in psoriasis patients receiving adalimumab or ustekinumab for moderate to severe plaque psoriasis

Goren, Amir; Carter, Chureen; Lee, Seina

doi:10.3109/09546634.2015.1049972

Cited by 13 publications

(12 citation statements)

References 24 publications

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“…In line with our study, the medication adherence rate ranged from 33% to 78% in a study by Gorin et al, and one-third of the patients discontinued their regular treatment due to forgetfulness to use their medicine, high cost of drugs, long duration of medical treatment, and other medical problems (25). On the other hand, Joeteck et al reported a medication adherence rate of 56.5%, which is consistent with the present study (26).…”

Section: Discussionsupporting

confidence: 82%

The Effects of a Self-Care Program on Promoting Self-Care Behaviors in Patients with Psoriasis

Karimipour

Sayadi

Shariati

et al. 2017

Jundishapur J Chronic Dis Care

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Background: Psoriasis is a chronic inflammatory disease with frequent recurrence. The associated complications cause disturbance in patients' quality of life. In addition to treatment procedures, use of self-care behaviors can be considered a cost-effective and applicable method in improving the patients' symptoms. Therefore, the present study aimed to investigate the effectiveness of a self-care program in promoting self-care behaviors of patients with psoriasis. Objectives: The present study aimed to investigate the effectiveness of a self-care program in promoting self-care behaviors among patients with psoriasis. Methods: This quasi experimental, before-after study was carried out on 32 patients. The educational program was implemented face-to-face and in groups (in areas such as medicine, bathing, and clothing). The samples were examined once every 2 weeks for 3 months. Two questionnaires and 1 self-report checklist with a correlation coefficient of 92.5% were used in this study. The validity of the questionnaires was determined using content validity. Data were analyzed using repeated measures ANOVA in SPSS. Results: The patients' demographics were as follows: mean age, 42.37%; males, 16 (55.2%) and females, 13 (44.8%); married, 21 (72.4%), single, 6 (20.7%), and widowed, 2 (6.9%); secondary school education, 13 (44.8%); average disease period, 9.03%; most self-employed and housewives (9, 31%); history of disease, 7 (24.1%); and physician-diagnosed disease, 29 (100%). The results showed that the mean medication adherence rate increased from 7% to 9.72% after the intervention, and comparison of self-care behaviors before and after the intervention showed that the frequency of most behaviors significantly increased. Conclusions:The results showed that training could improve self-care behaviors. Use of simple, low-cost, and available programs for self-care behaviors is effective in reducing the patients' symptoms and improving their conditions.

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Section: Discussionsupporting

confidence: 82%

The Effects of a Self-Care Program on Promoting Self-Care Behaviors in Patients with Psoriasis

Karimipour

Sayadi

Shariati

et al. 2017

Jundishapur J Chronic Dis Care

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“…In our cohort of 247 patients treated with adalimumab, etanercept, or ustekinumab for more than 350 days, only 15 patients (6.1%) had an MPR <80%, indicating nonadherence. These results are in agreement with self-reported patient adherence to biologics [13] but in stark contrast to the data of Goren et al [19], who recorded that 11.8 and 32.5% of patients were nonadherent to ustekinumab and adalimumab, respectively. In patients with rheumatoid arthritis the proportion of adherent patients has been reported to be as low as 11% (reviewed by De Vera et al [3]).…”

Section: Discussioncontrasting

confidence: 57%

“…4). Other authors have also reported lower adherence to etanercept than to ustekinumab or adalimumab [19,25]. …”

Section: Discussionmentioning

confidence: 99%

Patient Adherence to Biologic Agents in Psoriasis

Hsu

Gniadecki²

2016

Dermatology

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Background: Low adherence to therapies in psoriasis decreases treatment outcomes and increases the total health care costs. In spite of the wide use of biologic agents, patients' adherence to these drugs has not been extensively investigated. Objective: The aim of this study is to measure adherence to the biologic drugs in a population of patients treated for psoriasis vulgaris using the medication possession ratio (MPR) index and to survey patients' attitudes to the treatment. Methods: This is a single-center study on 247 patients with psoriasis vulgaris treated with adalimumab (n = 113), etanercept (n = 39), and ustekinumab (n = 95). MPR calculation was calculated monthly based on the hospital records documenting the dispensing of biologics to the patients. Clinical data [Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), presence of psoriatic arthritis, concomitant treatment, and cause for treatment discontinuation] were obtained from the national database DERMBIO. Patients' attitudes and beliefs were measured using the Medication Adherence Rating Scale (MARS). Results: A total of 93.5% of all patients had an MPR ≥0.8, indicating very good adherence. MPR was independent of patients' age, gender, median PASI or DLQI score, concomitant diagnosis of psoriatic arthritis, or treatment with methotrexate. MPR for etanercept was slightly lower than that for ustekinumab and adalimumab. The MARS questionnaire documented satisfactory understanding of the treatment and its adverse effects, and positive attitudes to the treatment. Conclusion: Adherence to biologic therapies is very high in patients with psoriasis, which is consistent with a positive attitude to the treatment.

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“…This is confirmed by the results obtained during analysis of patients' replies to the A14 Adherence Scale, where the item ‘My previous treatments were not efficient’ was significantly correlated with adherence. Our data collection was not designed to identify the impact of the active ingredient on adherence and can therefore not add information to the medication‐related adherence aspects reported elsewhere …”

Section: Discussionmentioning

confidence: 99%

“…Our data collection was not designed to identify the impact of the active ingredient on adherence and can therefore not add information to the medication-related adherence aspects reported elsewhere. 11,16,23,[25][26][27] Being asked for the main reason for non-adherence, dermatologists primarily name the patients' fear of adverse reactions. This thinking precipitates in their communication with the patient as the respondents strongly agree (12 of 13 dermatologists) that provision of enough information regarding possible risks and adverse effects enhances the patient's therapy adherence (see Table 4).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of adherence predictors for the treatment of moderate to severe psoriasis with biologics: the importance of physician–patient interaction and communication

Zschocke

Ortland²,

Reich

2017

Acad Dermatol Venereol

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Patient reported health outcomes and non-adherence in psoriasis patients receiving adalimumab or ustekinumab for moderate to severe plaque psoriasis

Abstract: UST versus ADA PsO bio-naïve patients reported higher clearing rates, better DLQI, and lower activity impairment.

Cited by 13 publications

References 24 publications

The Effects of a Self-Care Program on Promoting Self-Care Behaviors in Patients with Psoriasis

The Effects of a Self-Care Program on Promoting Self-Care Behaviors in Patients with Psoriasis

Patient Adherence to Biologic Agents in Psoriasis

Evaluation of adherence predictors for the treatment of moderate to severe psoriasis with biologics: the importance of physician–patient interaction and communication

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