Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors

Rui, Xu; Gu, Qing; Xiao, Shiji; Zhao, Ping; Ding, Zhi

doi:10.3389/fonc.2022.951485

Cited by 6 publications

(9 citation statements)

References 33 publications

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“…A prospective single institution cohort study of 356 patients in China used MDASI-GI to assess patient-reported gastrointestinal symptoms after gastrectomy. 7 Gastrointestinal symptoms were reported by 71% of patients 1 week after discharge. The most frequent symptom was F I G U R 1 Percentage of patients who underwent gastrectomy for cancers at a single cancer institution and reported symptoms as moderate to severe in the preoperative period and during postoperative days 1-3 or during postoperative days 4-7.…”

Section: Discussionmentioning

confidence: 98%

“…The results of this study are concordant with prior work describing high symptom burden after gastric surgery. A prospective single institution cohort study of 356 patients in China used MDASI‐GI to assess patient‐reported gastrointestinal symptoms after gastrectomy 7 . Gastrointestinal symptoms were reported by 71% of patients 1 week after discharge.…”

Section: Discussionmentioning

confidence: 99%

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High symptom burden in patients undergoing gastrectomy for cancer

Lilley,

Lu,

Robinson

et al. 2023

Journal of Surgical Oncology

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BackgroundThere is little data describing symptom burden before or after gastrectomy for patients with cancer. We aimed to examine the perioperative patterns of symptom severity in patients undergoing gastrectomy.MethodsIn this single‐institution prospective cohort study, patients scheduled to undergo gastrectomy for cancer completed serial symptom measurement questionnaires preoperatively, at postoperative day (POD) 1–3, and POD 4–7. The percent of patients with moderate to severe scores was calculated at each time point.ResultsThirty‐nine patients completed 94 surveys. Preoperatively, 46% reported at least one moderate/severe symptom. This increased to 88% during POD 1–3 and 79% during POD 4–7. During the preoperative period, 25% of patients reported moderate to severe interference in at least one aspect of daily life. This increased to 73% of patients at both POD 1–3 and POD 4–7.ConclusionsPatients undergoing gastrectomy for cancer frequently experience symptoms that interfere with daily life. A better understanding of these symptoms may improve patients' experiences with, and recovery from, gastrectomy.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

High symptom burden in patients undergoing gastrectomy for cancer

Lilley,

Lu,

Robinson

et al. 2023

Journal of Surgical Oncology

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“…This scale is speci cally designed to measure the occurrence and burden of symptoms in the gastrointestinal cancer population. It is a module of the larger Gastrointestinal Cancer Assessment Scale, developed based on general assessment scales [23][24][25]. The translated version of this scale has been widely used in China for measuring and assessing patient symptoms [26,27].…”

Section: The MD Anderson Symptom Inventory Gastrointestinal Version(m...mentioning

confidence: 99%

The symptom cluster and core symptoms of early recovery in patients after esophageal cancer surgery: A network analysis

Ji,

Zhang,

Shi

et al. 2023

Preprint

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Background Patients with esophageal cancer, one month after surgery, undergo a transitional period before discharge, which may trigger a range of emotional and physical adjustments, including physical and psychological symptoms. Although current research examines individual symptoms in isolation, it is crucial to comprehend the relationships between symptoms and the core symptoms for effective symptom management. Objective Our study aims to describe symptoms in patients in the early stages of postoperative recovery from esophageal cancer, identify symptom clusters, and explore core symptoms and the relationship between symptoms. Methods This study was a cross-sectional investigation utilizing convenience sampling to select 281 postoperative esophageal cancer patients from two hospitals in Henan Province, China. A self-administered general information questionnaire and Anderson's Gastrointestinal Tumour Symptom Evaluation Scale were employed to survey the symptoms. Symptom clusters were extracted via exploratory factor analysis, and a symptom network was constructed using R. Network analysis was used to estimate correlations among symptoms. Results Our study identified difficulty swallowing(86.8%), pain (86.8%), and feeling of sad(83.3%) as the most prevalent symptoms. Four symptom clusters were extracted: the eating-related symptom cluster, the fatigue and sleep symptom cluster, the difficulty swallowing and psychological symptom cluster, and the digestive reconstruction symptom cluster. In the symptom network, feeling of sad (rs = 0.979) and fatigue (rs = 0.845) had the largest value of strength centrality. Conclusion Multiple symptoms and symptom clusters are apparent in patients in the early stages of postoperative recovery from esophageal cancer. Feeling of sad and fatigue are the core symptoms in patients in the early stages of postoperative recovery from esophageal cancer. Healthcare professionals can design accurate interventions based on these core symptoms, reducing the role of sadness and fatigue in the symptom network and improving patients' quality of life.

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“…2,3 Up to 90% of patients who have undergone gastrectomy report experiencing gastrointestinal symptoms, including dysphagia, abdominal distension, pain, diarrhea, and, vomiting leading to malnutrition, which is associated with a poor prognosis. [4][5][6] One of the causes of maldigestion is exocrine pancreatic insufficiency (EPI), a disorder characterized by insufficient or abnormal production or activity of pancreatic juice. EPI can lead to steatorrhea, stomach distension, flatulence, and weight loss.…”

Section: Introductionmentioning

confidence: 99%

“…Survival rates for gastric cancer are improving, particularly since the introduction of neoadjuvant therapy; however, surgery remains the mainstay of curative treatment; total gastrectomy is the acknowledged surgical treatment for gastric cancer 2,3 . Up to 90% of patients who have undergone gastrectomy report experiencing gastrointestinal symptoms, including dysphagia, abdominal distension, pain, diarrhea, and, vomiting leading to malnutrition, which is associated with a poor prognosis 4–6 …”

Section: Introductionmentioning

confidence: 99%

A life‐threatening presentation of postgastrectomy exocrine pancreatic insufficiency: A case report

Rahimipour Anaraki,

Gholizadeh Mesgarha,

Bahadorizadeh

et al. 2023

Clinical Case Reports

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Key Clinical MessagePhysicians must be alert for the exocrine pancreatic insufficiency diagnosis through the follow‐up of postgastrectomy patients, regardless the severity and lag time. Urgent albumin and pancreatic enzyme replacement should be considered when diagnosed.AbstractIt is documented that exocrine pancreatic insufficiency (EPI) can develop after gastrectomy. Steatorrhea, malnutrition, and weight loss are common symptoms of the disease; however, it is usually mild to moderate postgastrectomy. This article reports a case of EPI manifested by hypoalbuminemia leading to dyspnea and anasarca, which are not typical symptoms of postgastrectomy EPI. A 61‐year‐old man with a history of gastric adenocarcinoma treated by total gastrectomy and chemoradiotherapy was admitted to the hospital with dyspnea and anasarca. Despite being diagnosed as a case of malignancy recurrence in another hospital, based on the symptoms described, no evidence of malignancy was found. His ascites and pleural effusion were determined to be caused by hypoalbuminemia. In addition, he claimed steatorrhea, and his stool elastase was lower than expected. EPI was diagnosed based on his medical history, paraclinical tests, and examinations. He remained asymptomatic for 1 year after being treated with albumin and pancreatic enzymes. Postgastrectomy EPI may be severe enough to cause steatorrhea or hypoalbuminemia. Hence, regardless of the severity of the presentation, physicians must be alert for this diagnosis throughout the follow‐up of patients with a history of gastrectomy. Urgent albumin and pancreatic enzyme replacement should be considered when diagnosed.

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Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors

Cited by 6 publications

References 33 publications

High symptom burden in patients undergoing gastrectomy for cancer

High symptom burden in patients undergoing gastrectomy for cancer

The symptom cluster and core symptoms of early recovery in patients after esophageal cancer surgery: A network analysis

A life‐threatening presentation of postgastrectomy exocrine pancreatic insufficiency: A case report

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