“…Repeated symptom assessment during radiotherapy reduced the patients' fatigue. 50 In contrast to previous studies showing that the physiological factors 16 cancer type and stage 6,9,18,19 or prior or concomitant chemotherapy 11,18,20 were associated with fatigue, our study did not reveal such associations. Nor was younger age, female sex, higher educational level, and living alone 6,8,10,11 related to worse fatigue when the variables presence of depressed mood and comorbidity were included in the multivariable regression model together with the other physiological, situational, and psychological influencing factors.…”
Section: Table 1 (Continued)contrasting
confidence: 99%
“…The theory proposes influencing factors that are physiological (eg, clinical data), situational (eg, demographics, lifestyle factors), and psychological (eg, mental state or mood). 16 Previous studies have demonstrated that different physiological factorssuch as type of cancer, 6 stage of disease, 9,18,19 concomitant chemotherapy, 11,[18][19][20] -and situational factors-such as higher educational level, and living alone 8,10 -were related to fatigue during radiotherapy. However, there are inconsistent findings regarding some factors' relationship with fatigue.…”
Background: Having knowledge of which patients are more likely to experience fatigue during radiotherapy and the relationship between fatigue and health-related quality of life (HRQL) is important to improve identification and care of patients experiencing burdensome fatigue. Objective: To identify subgroups of patients, varying in situational, physiological, and psychological factors, who are more likely to experience fatigue an ordinary week of radiotherapy, and to compare patients experiencing and not experiencing fatigue regarding perceived HRQL and functional performance, that is, daily and physical activity and work ability. Methods: Cross-sectional study of 457 patients (52% women) undergoing radiotherapy (38% breast, 32% prostate cancer), using self-reported questionnaire data on fatigue, HRQL and functional performance analyzed using multivariable regression models. Results: Of the 448 patients who answered the fatigue question, 321 (72%) experienced fatigue. Patients reporting any comorbidity or depressed mood were more likely to experience fatigue, relative risk (RR) 1.56 ([95% confidence interval (CI)] 1.13-2.16) and RR 2.57 (CI 1.73-3.83), respectively. Patients with fatigue reported worse HRQL and performed less physical activity, including daily ( P = .003), vigorous ( P = .003) and moderate ( P = .002) activity. Patients with and without fatigue reported 60% versus 40% sickness absence. Conclusion: Patients with depressed mood or comorbidity were more likely to experience fatigue an ordinary week of radiotherapy than other patients were. Patients experiencing fatigue perceived worse HRQL and performed less daily and physical activity compared to patients not experiencing fatigue. Cancer care practitioners may consider paying extra attention to these subgroups of patients.
“…Repeated symptom assessment during radiotherapy reduced the patients' fatigue. 50 In contrast to previous studies showing that the physiological factors 16 cancer type and stage 6,9,18,19 or prior or concomitant chemotherapy 11,18,20 were associated with fatigue, our study did not reveal such associations. Nor was younger age, female sex, higher educational level, and living alone 6,8,10,11 related to worse fatigue when the variables presence of depressed mood and comorbidity were included in the multivariable regression model together with the other physiological, situational, and psychological influencing factors.…”
Section: Table 1 (Continued)contrasting
confidence: 99%
“…The theory proposes influencing factors that are physiological (eg, clinical data), situational (eg, demographics, lifestyle factors), and psychological (eg, mental state or mood). 16 Previous studies have demonstrated that different physiological factorssuch as type of cancer, 6 stage of disease, 9,18,19 concomitant chemotherapy, 11,[18][19][20] -and situational factors-such as higher educational level, and living alone 8,10 -were related to fatigue during radiotherapy. However, there are inconsistent findings regarding some factors' relationship with fatigue.…”
Background: Having knowledge of which patients are more likely to experience fatigue during radiotherapy and the relationship between fatigue and health-related quality of life (HRQL) is important to improve identification and care of patients experiencing burdensome fatigue. Objective: To identify subgroups of patients, varying in situational, physiological, and psychological factors, who are more likely to experience fatigue an ordinary week of radiotherapy, and to compare patients experiencing and not experiencing fatigue regarding perceived HRQL and functional performance, that is, daily and physical activity and work ability. Methods: Cross-sectional study of 457 patients (52% women) undergoing radiotherapy (38% breast, 32% prostate cancer), using self-reported questionnaire data on fatigue, HRQL and functional performance analyzed using multivariable regression models. Results: Of the 448 patients who answered the fatigue question, 321 (72%) experienced fatigue. Patients reporting any comorbidity or depressed mood were more likely to experience fatigue, relative risk (RR) 1.56 ([95% confidence interval (CI)] 1.13-2.16) and RR 2.57 (CI 1.73-3.83), respectively. Patients with fatigue reported worse HRQL and performed less physical activity, including daily ( P = .003), vigorous ( P = .003) and moderate ( P = .002) activity. Patients with and without fatigue reported 60% versus 40% sickness absence. Conclusion: Patients with depressed mood or comorbidity were more likely to experience fatigue an ordinary week of radiotherapy than other patients were. Patients experiencing fatigue perceived worse HRQL and performed less daily and physical activity compared to patients not experiencing fatigue. Cancer care practitioners may consider paying extra attention to these subgroups of patients.
“…Radiotherapy‐induced fatigue may last for a long period of time, even after radiotherapy is completed (American Cancer Society, 2020). Many studies have attempted to explore the course of radiotherapy‐induced fatigue, but the results have been inconsistent (Abel et al, 2022; Avelar et al, 2019; Dickinson et al, 2021; Ferris et al, 2018; Holliday et al, 2016; Lilleby et al, 2016; Wan et al, 2019). The pattern of fatigue may differ by type of cancer (Avelar et al, 2019; Saligan et al, 2016).…”
BackgroundFatigue is a common symptom in cancer patients receiving radiotherapy. However, previous studies report inconsistent patterns of fatigue change.AimThe aim of this study was to estimate changes in fatigue among patients with cancer before, during, and after radiotherapy.MethodsFive databases (PubMed, SDOL, CINAHL Plus with Full Text, Medline [ProQuest], and ProQuest Dissertations) were searched for studies published from January 2006 to May 2021. Three effect sizes of fatigue change (immediate, short‐term, and long‐term) were calculated for each primary study using standardized mean difference. A random‐effect model was used to combine effect sizes across studies. Subgroup analyses and meta‐regression were performed to identify potential categorical and continuous moderators, respectively.ResultsSixty‐five studies were included in this meta‐analysis. The weighted mean effect size for immediate, short‐term, and long‐term effects was 0.409 (p < .001; 95% CI [0.280, 0.537]), 0.303 (p < .001; 95% CI [0.189, 0.417]), and 0.201 (p = .05; 95% CI [−0.001, 0.404]), respectively. Studies with prostate cancer patients had a significantly higher short‐term (0.588) and long‐term weight mean effect size (0.531) than studies with breast (0.128, −0.072) or other cancers (0.287, 0.215). Higher radiotherapy dosage was significantly associated with a higher effect size for both immediate (β = .0002, p < .05) and short‐term (β = .0002, p < .05) effect.Linking Evidence to ActionFindings from this meta‐analysis indicated that radiotherapy‐induced fatigue (RIF) exist for more than 3 months after the completion of treatment. Assessment of radiation‐induced fatigue in cancer patients should extend long after treatment completion, especially for patients with prostate cancer and patients receiving a higher radiation dose. Interventions to reduce fatigue tailored for different treatment phases may be developed.
“…Por otro lado, durante su enfermedad experimenta fatiga o cansancio oncológico, que viene a ser un sentimiento subjetivo y continuo que tiene relación con el tratamiento o el cáncer, e interfiere con la función rutinaria de la mujer con cáncer de mama y es un síntoma frecuente 7 . Se presenta, generalmente, después del sueño o descanso y es de magnitud, regularidad y persistencia superior al cansancio que experimenta una mujer normal, es factor restrictivo para las actividades diarias y tiene una influencia afectiva negativa 8 .…”
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