Patient-Reported Bowel and Urinary Function in Long-Term Survivors of Squamous Cell Carcinoma of the Anus Treated With Definitive Intensity Modulated Radiation Therapy And Concurrent Chemotherapy

De, Brian; Corrigan, Kelsey L.; Rooney, Michael K.; Ludmir, Ethan B.; Das, Prajnan; Smith, Grace L.; Taniguchi, Cullen M.; Minsky, Bruce D.; Koay, Eugene J.; Koong, Albert C.; Morris, Van K.; Messick, Craig A.; You, Yong; Chang, George J.; Westney, O. Lenaine; González, Graciela M. Nogueras; Holliday, Emma B.

doi:10.1016/j.ijrobp.2022.05.009

Cited by 8 publications

(2 citation statements)

References 54 publications

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“…As shown by Lin et al’s RCT, considering a patient’s total experience may reveal more about toxicity than counting individual adverse events [ 45 ]. Furthermore, recent studies on bowel, urinary, and sexual function patient-reported outcomes [ 105 , 106 ] in long term survivors of anal cancer after concurrent chemoradiotherapy highlight the importance of considering long-term toxicities, validated patient-reported outcomes, and quality of life.…”

Section: Discussionmentioning

confidence: 99%

Proton Therapy in the Management of Luminal Gastrointestinal Cancers: Esophagus, Stomach, and Anorectum

Kobeissi

Simone

Hilal

et al. 2022

Cancers

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While the role of proton therapy in gastric cancer is marginal, its role in esophageal and anorectal cancers is expanding. In esophageal cancer, protons are superior in sparing the organs at risk, as shown by multiple dosimetric studies. Literature is conflicting regarding clinical significance, but the preponderance of evidence suggests that protons yield similar or improved oncologic outcomes to photons at a decreased toxicity cost. Similarly, protons have improved sparing of the organs at risk in anorectal cancers, but clinical data is much more limited to date, and toxicity benefits have not yet been shown clinically. Large, randomized trials are currently underway for both disease sites.

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Section: Discussionmentioning

confidence: 99%

Proton Therapy in the Management of Luminal Gastrointestinal Cancers: Esophagus, Stomach, and Anorectum

Kobeissi

Simone

Hilal

et al. 2022

Cancers

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show abstract

“… 1 However, radiation to the pelvis can lead to significant acute and permanent side effects that impair patient quality of life (QOL). 2 , 3 , 4 …”

Section: Introductionmentioning

confidence: 99%