Patient-Relevant Outcomes in Psoriasis

Abstract

IMPORTANCEThere is a need to define which outcomes matter to patients with psoriasis to deliver value for the patient when managing their condition.OBJECTIVES To generate a comprehensive overview of all outcomes relevant in the management of psoriasis as defined by patients.EVIDENCE REVIEW A systematic review was performed by searching 3 databases (MEDLINE, Embase, and Web of Science) from August 1, 2019, until March 27, 2021, using a comprehensive search strategy consisting of 4 concepts including psoriasis, patients, outcomes, and relevance. A (citing) reference search was also performed of all retrieved articles. Two independent reviewers screened the retrieved records by title/abstract against the eligibility criteria. Studies were eligible for inclusion if they reported on the importance of outcomes for patients with psoriasis. No language restrictions were used. Data extraction and quality assessment were also performed independently. Quality assessment was done using the QUALSYST tool.FINDINGS In total, 10 365 records were screened for eligibility, of which 24 studies were included for synthesis. A total of 23 317 patients were evaluated, and 273 (154 unique) items were retrieved. These items were aggregated into 23 outcomes: (almost) complete clearance; symptom control; difficult location clearance; time to clearance; treatment efficacy, sustainability, safety, tolerability, and convenience; comorbidity control; daily and social activity; emotional well-being; intimate relationships; productivity; health-related quality of life; confidence in care; control of disease; communication with care professional; information from other sources than care professional; and cost of care (societal and for the patient). These were then further grouped into 4 core areas: physical/clinical, life impact, resource use, and adverse effects. The mean overall quality of the studies was 75.6% (range, 35.7%-100%).CONCLUSIONS AND RELEVANCE This systematic review analyzed patient-relevant outcomes reported in patients with psoriasis to aid in the transition to a value-based treatment approach.

Value in psoriasis (IRIS) trial: implementing value-based healthcare in psoriasis management – a 1-year prospective clinical study to evaluate feasibility and value creation

“…Therefore, there was also no set of outcomes available that grasped the overall value healthcare professionals created in daily clinical practice. In previous work, we have defined which outcomes matter to psoriasis patients and proposed a value-based outcome set (VOS), which can be used to direct psoriasis care in a value-based manner 14 15…”

Initiating value‐based healthcare in psoriasis: Proposing a value‐based outcome set for daily clinical practice

“…A mixed method approach was used consisting of four phases (a more detailed description can be found in the eMethods). Formerly, a systematic review (SR) was conducted, providing an overview of all patient‐relevant outcomes defined in current literature 18 . These 23 outcomes were then presented to a group of patients, using a modified nominal group technique (NGT), to establish whether these results represented all of their relevant outcomes.…”

“…Formerly, a systematic review (SR) was conducted, providing an overview of all patient-relevant outcomes defined in current literature. 18 These 23 outcomes were then presented to a group of patients, using a modified nominal group technique (NGT), to establish whether these results represented all of their relevant outcomes. Subsequently, these outcomes were ranked according to importance by 120 patients attending our academic specialized psoriasis clinic (PsoPlus) at Ghent University Hospital, Belgium.…”

Determining patient value profiles in psoriasis

“…This was extensively reviewed by our group as we conducted a systematic review which analysed patient-relevant outcomes in psoriasis and subsequently performed a ranking exercise in a cohort of psoriasis patients to discover the determinants of true value. 6,7 We found that variables such as for example, age, gender, disease duration and disease severity influenced the importance of several outcomes. 7 Several of these findings were also corroborated by previous studies.…”