Patient-Related Risk Factors for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review

Mosa, Abu Saleh Mohammad; Hossain, Akm Mosharraf; Lavoie, Beau James; Yoo, Illhoi

doi:10.3389/fphar.2020.00329

Cited by 65 publications

(82 citation statements)

References 61 publications

(121 reference statements)

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“…This study found that anticipatory nausea in head and neck cancer patients undergoing chemotherapy was more common in men over 40 years of age. This result is supported by Mosa, Hossain, Lavoie & Yoo (2020), who found a higher proportion of men who had head and neck cancer accompanied by anticipatory nausea. At the age of 40 years and over, the lower esophageal muscle weakens; this is also caused by the influence of drugs consumed to reduce symptoms of chronic disease.…”

Section: Discussionmentioning

confidence: 53%

The Effect of Hypnotherapy on Anticipatory Nausea in Head and Neck Cancer Patients Undergoing Chemotherapy

Hamdani¹,

Prasetyo

Anggorowati

2020

Nurs. Med. J. Nursing

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Background: One of the chemotherapy side effects on head and neck cancer patients is anticipatory nausea. However, the anticipatory nausea problem has not been properly resolved. Nausea might be psychologically reduced by hypnotherapy. There only have been very few studies conducted to examine the effects of hypnotherapy in alleviating anticipatory nausea.Purpose: This study aimed to determine the effect of hypnotherapy using Hanung induction technique on anticipatory nausea in head and neck cancer patients undergoing chemotherapy.Methods: This research employed a pre-post test of quasi-experiment with control group design. Consecutive sampling technique was used to obtain 64 subjects who met inclusion and exclusion criteria and were equally divided into the intervention and control groups. Hypnotherapy as the intervention was carried out in two sessions, each of which lasted for 20 minutes, with a week distance between sessions. The data were collected using a visual analog scale (VAS), which was used twice to measure anticipatory nausea and analyzed using the paired and independent-sample t-test.Result: The results showed that the mean score of anticipatory nausea in the intervention group reduced from 7.6±1.4 to 2.3 ±1.2 after hypnotherapy, while the mean in the control group increased from 6.4±1.6 to 6.7±1.4. There was a significant difference in the score of anticipatory nausea after the implementation of hypnotherapy between the intervention and the control group (p<0.001).Conclusion: The study concluded that hypnotherapy is effective in reducing the intensity of anticipatory nausea in head and neck cancer patients undergoing chemotherapy. Therefore, hypnotherapy can be applied by oncology nurses as an intervention in treating anticipatory nausea.

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Section: Discussionmentioning

confidence: 53%

The Effect of Hypnotherapy on Anticipatory Nausea in Head and Neck Cancer Patients Undergoing Chemotherapy

Hamdani¹,

Prasetyo

Anggorowati

2020

Nurs. Med. J. Nursing

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“…CINV is one of the notable toxicities affecting cancer patients. In addition to treatment‐related risk factors for CINV such as emetogenicity risk of chemotherapy, infusion rate, inadequate prophylaxis, and lack of maintenance antiemetics, patient‐related risk factors include female sex, younger age, previous experience of CINV, anxiety, and history of morning sickness 27 . Moreover, genetic factors such as HTR3 , ABCB1 , and CYP2D6 genes had been reported as potential predictors for developing CINV 28 .…”

Section: Discussionmentioning

confidence: 99%

Single daily dosing versus divided dosing intravenous ondansetron to prevent chemotherapy‐induced nausea and vomiting among children: A comparative randomized double‐blind controlled trial

Ruktrirong

Traivaree

Monsereenusorn

et al. 2021

Pediatric Blood & Cancer

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Background Chemotherapy‐induced nausea and vomiting (CINV) is a common complication in cancer treatment. Ondansetron is an effective antiemetic drug widely used to prevent CINV; however, the effective administrative dosing strategies among pediatrics remain unclear. The study aimed to investigate clinical effectiveness of single daily dosing versus divided dosing ondansetron. Methods In all, 194 children undergoing chemotherapy were randomized to receive either single daily dosing (0.3 mg/kg/dose) or divided dosing (0.15 mg/kg/dose every 8 hours) intravenous ondansetron for 24 hours. Clinical parameters including number of emesis episodes, nausea scores, appetite levels, parent's satisfaction, and adverse effects within 24 hours were analyzed. Results No significant differences were found between the two dosing strategies concerning number of emesis episodes and parent's satisfaction. However, nonleukemic hematologic malignancies and concurrent administration of intrathecal methotrexate–hydrocortisone–cytarabine (IT‐MHA) were associated with increased risk of acute‐phase vomiting. Interestingly, none of the patients aged under 7 years, receiving divided dosing ondansetron, presented nausea symptoms compared with those receiving single daily dosing (p‐value .034). No significant differences regarding headache were observed between the two dosing strategies and none of the patients experienced QTc prolongation. Conclusion Ondansetron administered as divided dosing should be considered among children aged under 7 years to prevent chemotherapy‐induced nausea and among patients receiving low emetogenic chemotherapy to maintain their appetite. Both administrative dosing strategies were well tolerated with no significant adverse effects.

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“…Patients undergoing other drugs or multi-day chemotherapy regimens, or receiving multicycle treatments remain faced with a higher risk of CINV. Also, CINV is affected by several risk factors, such as a history of nausea/vomiting, female sex, the expectancy of CINV, younger age, anxiety, history of morning sickness, and low alcohol intake [22]. Antiemetic prophylaxis based on a risk model guide led to improved control effect of acute and delayed CINV [23].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

Wang

et al. 2020

Chin Med

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Background: Chemotherapy-induced nausea and vomiting (CINV) is a common and distressing side effect. We conducted this clinical trial to compare the effectiveness of true acupuncture vs. sham acupuncture in controlling chemotherapy-induced nausea and vomiting (CINV) among patients with advanced cancer. Methods: A total of 134 participants were randomly allocated into true acupuncture (TA) (n = 68) and sham acupuncture (SA) (n = 66) groups. Participants in both groups received acupuncture session twice on the first day of chemotherapy, and once consecutively on the following 4 days. The primary outcome was using the Common Terminology Criteria for Adverse Events (CTCAE) to assess CINV. The secondary outcome measures were the Eastern Cooperative Oncology Group score (ECOG), Simplified Nutritional Appetite Questionnaire (SNAQ), and Hospital Anxiety and Depression scale (HADS). Results: Compared to the SA group, the TA group didn't show significant improvement in complete response rates of chemotherapy-induced nausea and vomiting (all P > 0.05). However, the TA group could modestly reduce the severity of nausea (from day-3 to day-21, P < 0.05) or vomiting (from day-4 to day-21, P < 0.05), which is notably superior to the control group. Besides, TA promoted the nutritional status of patients with a significantly higher score comparing to the SA group on day 14 (21.82 vs.20.12, P = 0.003) and day 21 (22.39 vs. 20.43, P = 0.001). No apparent differences were found in anxiety and depression assessment between these groups. Participants in both groups were well tolerant of acupuncture therapy. There was no adverse event occurs in our study. Conclusion: Acupuncture as an adjunctive approach could alleviate the severity of chemotherapy-induced nausea and vomiting compared to the sham control, even though the effect of acupuncture in preventing CINV occurring is relatively modest.

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Patient-Related Risk Factors for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review

Cited by 65 publications

References 61 publications

The Effect of Hypnotherapy on Anticipatory Nausea in Head and Neck Cancer Patients Undergoing Chemotherapy

The Effect of Hypnotherapy on Anticipatory Nausea in Head and Neck Cancer Patients Undergoing Chemotherapy

Single daily dosing versus divided dosing intravenous ondansetron to prevent chemotherapy‐induced nausea and vomiting among children: A comparative randomized double‐blind controlled trial

Efficacy of acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting in patients with advanced cancer: a multi-center, single-blind, randomized, sham-controlled clinical research

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