Patient quality of life following induction of oral immunotherapy for food allergy

Epstein‐Rigbi, Naama; Katz, Yitzhak; Goldberg, Michael R.; Levy, Michael B.; Nachshon, Liat; Elizur, Arnon

doi:10.1111/pai.12528

Cited by 40 publications

(50 citation statements)

References 29 publications

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“…Oral immunotherapy is a promising therapy for FA. Studies in patients and parents have demonstrated a general positive effect of OIT on some aspects of QoL, especially food anxiety and social and dietary limitation but not emotional impact . Certain characteristics seem to be associated with greater improvements in caregiver QoL: in a prospective randomized study, QoL improved more in caregivers of participants older than 10 years or desensitized to more than 4 food allergens than those who were not …”

Section: Results From the Selected Literaturementioning

confidence: 99%

Anxiety and food allergy: A review of the last two decades

Polloni

Muraro

2020

Clin Experimental Allergy

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Food allergy (FA) is recognized as a growing public health burden affecting 5%‐10% of children worldwide. Several unique features specific to FA elicit high levels of emotional distress and anxiety in patients and caregivers, the first among all the possibility of a life‐threatening reaction. Anxiety disorders are highly prevalent in patients with chronic disease, but remain undertreated despite significant negative consequences on patient health. This review aimed to offer a comprehensive overview of literature data on FA and anxiety of the last two decades. A review of the medical and psychological literature from the year 2000 (MEDLINE, PubMed and PsycINFO) was done using the keywords “anxiety” and “food allergy.” Clinical implications for disease management, various manifestations in different target groups, proper interventions and possible explanations on the nature of the association between FA and anxiety have been discussed, as well as limitations and further research directions. The relationship between FA and anxiety is attributed to FA‐specific fears and anxiety, rather than a general propensity towards anxiety. Some anxiety—short‐lived and related to key events–is to be expected and may even be helpful if it sustains allergen avoidance and preparedness to emergency. However, some data reported that increased anxiety did not improve adherence. Rather, high levels of anxiety have been demonstrated counterproductive and related to maladaptive coping. Further research is needed to elucidate the association between FA and anxiety, especially to understand biopsychosocial directions of the underlying mechanisms and to build proper, effective, standardized protocols of intervention. Clinicians must be aware of the association between FA and anxiety, understand their role in recognizing maladaptive anxiety and encouraging to seek psychological support when needed.

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Section: Results From the Selected Literaturementioning

confidence: 99%

Anxiety and food allergy: A review of the last two decades

Polloni

Muraro

2020

Clin Experimental Allergy

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“…Discordances have been found in a study examining changes in QoL of children with FA during the updosing phase of OIT with improvement in 35%‐50% of patients, but deterioration in 25%‐30% . Certainly, a lower maximal tolerated dose during OIT induction is associated with worse indices of QoL primarily in children . Consequently, if the outcome of OFC or desensitization protocol does not change children's diet, and the fear for accidental exposure does not drive the need for accurate diagnosis, and then part of the beneficial effect of the food reintroduction might be lacking…”

Section: Therapeutic Approachesmentioning

confidence: 99%

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depend on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution, and infections. Preventive strategies may include avoidance measures, diet supplements, and early complementary food introduction. Overall, the management of allergic diseases has been improving to date toward a patient's tailored approach. This review will cover the current understanding of risk factors, prediction, and management of food allergy and atopic dermatitis in childhood and discuss how these may contribute to the modification of the natural history of food allergy and atopic dermatitis.

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“…In this study, Epstein Rigbi et al. investigated the factors affecting quality of life in patients during the first week of OIT for food allergy. For this purpose, the Food Allergy Quality of Life Questionnaire for parents of children aged 0–12 years was translated into Hebrew and validated.…”

Section: Patients Quality Of Life Following Induction Of Oral Immunotmentioning

confidence: 99%

The Editor recommends this issue’s articles to the reader

2016

Pediatric Allergy Immunology

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Patients quality of life following induction of oral immunotherapy for food allergyAlthough patients' quality of life improves upon completion of oral immunotherapy (OIT), little is known about the influences of the treatment process itself. During treatment, patients and their parents endure many difficulties, including repeated exposures to an allergen they are used to avoid, a process which some find aversive, as well as reactions, some of which are severe requiring injectable epinephrine. The initial induction phase might be particularly significant. It is during this week that the maximal tolerated dose of each patient is established, a dose which represents the severity of the patient's allergy and which predicts the course of his treatment, including its length and odds for success. Thus, the initial induction week might adversely affect patients' quality of life.In this study, Epstein Rigbi et al.(1) investigated the factors affecting quality of life in patients during the first week of OIT for food allergy. For this purpose, the Food Allergy Quality of Life Questionnaire for parents of children aged 0-12 years was translated into Hebrew and validated. The questionnaire was then completed by 119 parents of children undergoing OIT for cow's milk, egg and peanut allergy, at the end of the first induction. In addition to pre-OIT reactions' severity, a lower maximal tolerated starting dose particularly in school-aged children, was found to adversely affect patients' quality of life, This study is the first to examine the quality of life of patients during the process of OIT. The results emphasize that some aspects of the process itself might negatively affect patient's quality of life. This should be recognized by OIT programmes as it might lead to patient non-compliance with the treatment. It is of interest to examine how patients' quality of life continues to change throughout the treatment process and which factors mostly affect it.

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Patient quality of life following induction of oral immunotherapy for food allergy

Abstract: Pre-OIT reaction severity affects quality of life in both preschool and school-aged food-allergic children. In contrast, a lower maximal tolerated dose during OIT induction is associated with worse indices of quality of life primarily in children aged 6-12 years.

Cited by 40 publications

References 29 publications

Anxiety and food allergy: A review of the last two decades

Anxiety and food allergy: A review of the last two decades

Food allergy and atopic dermatitis: Prediction, progression, and prevention

The Editor recommends this issue’s articles to the reader

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