Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK

Wadsley, Jonathan; Armstrong, N.; Bassett-Smith, V.; Beasley, Matthew; Chandler, Robert W.; Cluny, L.; Craig, Allison J; Farnell, Kate; Garcez, Kate; Garnham, N.; Graham, K.; Hallam, Aida; Hill, S.; Hobrough, H.; McKiddie, F.; Strachan, Mwj

doi:10.1016/j.clon.2022.07.002

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…The wide range of RAI uptake observed is also reflected by the wide range of absorbed dose delivered to lesions from a fixed 5.5-GBq administration to patients with advanced DTC. This administration is considered standard practice in the United Kingdom and in line with national guidelines and was therefore used in the current study ( 20 ). The wide range agrees with results presented previously ( 21 , 22 ) and might explain the variations in outcome observed among patients.…”

Section: Discussionmentioning

confidence: 99%

The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer

et al. 2023

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Section: Discussionmentioning

confidence: 99%

The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer

et al. 2023

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“…This precautionary measure minimized radiation exposure to the breast and reduced the risk of clothing contamination from RAI leakage. (4) All patients received practical guidance on radiation protection measures during the restricted period postdose administration, including avoiding close contact with children and pregnant individuals, laundering personal clothing separately, refraining from bed-sharing and sexual activity, daily showering, and increased water intake [16].…”

Section: Administration Of Radioactive Iodine Therapymentioning

confidence: 99%

Factors affecting timing of hypothyroidism following radioactive iodine therapy (RAIT) for patients with Graves’ disease: A 12-month observational study

Mahmoud,

Alsanory,

Mostafa

et al. 2024

Nuclear Medicine Communications

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Background: This retrospective study analyzed factors influencing hypothyroidism development after radioactive iodine therapy for Graves’ disease. Patients and methods Three hundred and three patients with Graves’ disease treated with radioactive iodine (RAI) from 2013 to 2022 at two Egyptian hospitals were included. Data collected included demographics, lab values, thyroid imaging, RAI doses, and outcomes. Patients were followed for ≥1 year to assess hypothyroidism onset. Results At the end of 1 year, around 79.5% of the individuals developed hypothyroidism while 12.5% continued to experience hyperthyroidism. The onset of hypothyroidism occurred earlier in those with thyroid volume (≤75.5 cm3), lower thyroid weight (≤84.7 g), thyroid uptake (≤18.8%), and higher RAI dose/volume (≥0.1022 mCi/ml) (P < 0.001). Additionally, there was a correlation between anti-thyroid peroxidase (anti-TPO) antibodies and faster development of hypothyroidism compared to those who were negative for antibodies (2.9 vs 8.9 months, P = 0.001). When considering factors in analysis it was found that anti-TPO antibodies were the only independent predictor, for developing hypothyroidism (hazard risk 30.47, P < 0.001). Additionally, thyroid volume and uptake independently predicted successful treatment outcomes (P < 0.05). Conclusion Positive anti-TPO antibodies strongly predict hypothyroidism risk after RAI therapy for Graves’ disease. Smaller thyroid size, lower uptake, and higher RAI dose/volume correlate with earlier hypothyroidism onset but are less significant predictors than anti-TPO status. Findings can guide RAI therapy personalization to optimize outcomes.

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Impact on Non Surgical Management and Trials of Thyroid Cancer

Farnell,

Wadsley

2023

Practical Management of Thyroid Cancer

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Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK

Cited by 5 publications

References 39 publications

The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer

The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer

Factors affecting timing of hypothyroidism following radioactive iodine therapy (RAIT) for patients with Graves’ disease: A 12-month observational study

Impact on Non Surgical Management and Trials of Thyroid Cancer

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