Patient preference in migraine therapy

Díez, Fernando Iglesias; Straube, Andreas; Zanchin, Giorgio

doi:10.1007/s00415-006-0352-3

Cited by 18 publications

(6 citation statements)

References 22 publications

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“…We conducted a systematic review of literature focusing on studies on primary headache addressing the acute relief of pain, following the PRISMA guidelines [13].…”

Section: Methodsmentioning

confidence: 99%

A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

et al. 2018

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BackgroundPrimary headache are prevalent and debilitating disorders. Acute pain cessation is one of the key points in their treatment. Many drugs have been studied but the design of the trials is not usually homogeneous. Efficacy of the trial is determined depending on the selected primary endpoint and usually other different outcomes are measured. We aim to critically appraise which were the employed outcomes through a systematic review.MethodsWe conducted a systematic review of literature focusing on studies on primary headache evaluating acute relief of pain, following the PRISMA guideline. The study population included patients participating in a controlled study about symptomatic treatment. The comparator could be placebo or the standard of care. The collected information was the primary outcome of the study and all secondary outcomes. We evaluated the studied drug, the year of publication and the type of journal. We performed a search and we screened all the potential papers and reviewed them considering inclusion/exclusion criteria.ResultsThe search showed 4288 clinical trials that were screened and 794 full articles were assessed for eligibility for a final inclusion of 495 papers. The studies were published in headache specific journals (58%), general journals (21.6%) and neuroscience journals (20.4%).Migraine was the most studied headache, in 87.8% studies, followed by tension type headache in 4.7%. Regarding the most evaluated drug, triptans represented 68.6% of all studies, followed by non-steroidal anti-inflammatories (25.1%). Only 4.6% of the papers evaluated ergots and 1.6% analyzed opioids.The most frequent primary endpoint was the relief of the headache at a determinate moment, in 54.1%. Primary endpoint was evaluated at 2-h in 69.9% of the studies. Concerning other endpoints, tolerance was the most frequently addressed (83%), followed by headache relief (71.1%), improvement of other symptoms (62.5%) and presence of relapse (54%). The number of secondary endpoints increased from 4.2 (SD = 2.0) before 1991 to 6.39 after 2013 (p = 0.001).ConclusionHeadache relief has been the most employed primary endpoint but headache disappearance starts to be firmly considered. The number of secondary endpoints increases over time and other outcomes such as disability, quality of life and patients’ preference are receiving attention.

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“…We conducted a systematic review of literature focusing on studies on primary headache addressing the acute relief of pain, following the PRISMA guidelines [13].…”

Section: Methodsmentioning

confidence: 99%

A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

et al. 2018

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Section: Acute Symptomatic Treatment For Migrainementioning

confidence: 99%

“…Preferences and values for acute symptomatic treatment were reported in 14 studies [24][25][26][27][28][29][30][31][32][33][34][35][36][37]. For treatment process, therapies with a faster onset of action, a longer duration of the effects, fewer adverse events, and lower price were preferred [26][27][28][29][30][31][32][33][34][35]37]. Triptans were the most commonly used drugs, and the order of priority for dosage form of triptans was tablets, nasal spray, and subcutaneous injection [24,27,30].…”

Section: Acute Symptomatic Treatment For Migrainementioning

confidence: 99%

“…Triptans were the most commonly used drugs, and the order of priority for dosage form of triptans was tablets, nasal spray, and subcutaneous injection [24,27,30]. For treatment outcome, patients expected rapid pain relief, complete pain relief, return to normal activities, no recurrence, and no adverse events from their treatment [24,[27][28][29][30][31][32][33][34][35][36][37]. More details are shown in Table 5.…”

Section: Acute Symptomatic Treatment For Migrainementioning

confidence: 99%

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Patient Preferences and Values in Decision Making for Migraines: A Systematic Literature Review

Xu¹,

Ji²,

Shen

2021

Pain Research and Management

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Objective. To comprehensively summarize the evidence on the preferences and values of migraine patients. Methods. We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Sino-Med, Chongqing VIP, and Wanfang Data for studies on the preferences and values of migraine patients. A qualitative review was performed, but no quantitative synthesis. Results. Twenty‐one studies were finally included, involving a total of 8701 participants. Patients expected a cure, to be symptom-free, a reduction in frequency of headaches, a reduction in severity of headaches, and an improved quality of life from their preventive treatment. Patients expected rapid pain relief, complete pain relief, return to normal activities, no recurrence, and no adverse events from their acute symptomatic treatment. Conclusion. Efficacy is the primary consideration in the treatment of migraine. Specifically, the most important embodiment of patient preferences and values is the reduced frequency of attacks with preventive treatment as well as prompt analgesia with acute symptomatic treatment.

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“…Research has been conducted to identify and quantify patient preferences for a wide range of treatment options and health states. For example, some studies have asked patients to indicate which treatment option they preferred after receiving multiple treatments in a clinical trial with a crossover design 7,9,21. Research participants have also been asked to express preferences among hypothetical health states that they have not necessarily experienced 22.…”

Section: Background: Patient Preferencementioning

confidence: 99%

Preferences related to attention-deficit/hyperactivity disorder and its treatment

Brunt

Matza²,

Classi³

et al. 2011

PPA

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ObjectivesA growing body of literature has highlighted the importance of considering patient preferences as part of the medical decision-making process. The purpose of the current review was to identify and summarize published research on preferences related to attention-deficit/hyperactivity disorder (ADHD) and its treatment, while suggesting directions for future research.MethodsA literature search identified 15 articles that included a choice-based assessment of preferences related to ADHD.ResultsThe 15 studies were grouped into four categories based on preference content: preference for a treatment directly experienced by the respondent or the respondent’s child; preference for general treatment approaches; preference for a specific treatment attribute or outcome; and preference for aspects of ADHD-related treatment. Preference assessment methods ranged from global single items to detailed choice-based procedures, with few studies using rigorously developed assessment methods. Respondents included patients with ADHD, clinicians, parents, teachers, and survey respondents from the general population. Factors influencing preference include treatment characteristics, effectiveness for specific symptoms, side effects, and respondent demographics. Minimal research has examined treatment preferences of adults with ADHD.DiscussionBecause there is no dominant treatment known to be the first choice for all patients, ADHD is a condition for which individual preferences can play an important role when making treatment decisions for individual patients. Given the potential role of preferences in clinical decision-making, more research is needed to better understand the preferences of patients with ADHD and other individuals who are directly affected by the disorder, such as parents and teachers.

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Patient preference in migraine therapy

Cited by 18 publications

References 22 publications

A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches

Patient Preferences and Values in Decision Making for Migraines: A Systematic Literature Review

Preferences related to attention-deficit/hyperactivity disorder and its treatment

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