Patient Outcomes from Lung Cancer and Diabetes Mellitus: A Matched Case–Control Study

Karlin, Nina J.; Amin, Shailja; Buras, Matthew R.; Kosiorek, Heidi E.; Verona, Patricia M; Cook, Curtiss B.

doi:10.4155/fsoa-2017-0081

Cited by 31 publications

(40 citation statements)

References 23 publications

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“…On the contrary, several studies found that diabetes does not impact overall survival in lung cancer [94], and may even be associated with longer survival rates [85]. Furthermore, another study found that diabetes may play a protective role against lung metastasis [95], suggesting that the role of diabetes in lung cancer needs further clarification.…”

Section: Clinical Presentationmentioning

confidence: 99%

Diabetes and Lung Disease: An Underestimated Relationship

Khateeb

Fuchs

Khamaisi

2019

Review of Diabetic Studies

123

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■ AbstractBACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and oxidative stress which may target many organs such as the kidney, retina, and the vascular system. The pathophysiology, mechanisms, and consequences of diabetes on these organs have been studied widely. However, no work has been done on the concept of the lung as a target organ for diabetes and its implications for lung diseases. AIM: In this review, we aimed to investigate the effects of diabetes and hypoglycemic agent on lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, and lung cancer. We also reviewed the potential mechanisms by which these effects may affect lung disease patients. RESULTS: Our results suggest that diabetes can affect the severity and clinical course of several lung diseases. CONCLUSIONS: Although the diabetes-lung association is epidemiologically and clinically well-established, especially in asthma, the underlying mechanism and pathophysiology are not been fully understood. Several mechanisms have been suggested, mainly associated with the proinflammatory and proliferative properties of diabetes, but also in relation to micro-and macrovascular effects of diabetes on the pulmonary vasculature. Also, hypoglycemic drugs may influence lung diseases in different ways. For example, metformin was considered a potential therapeutic agent in lung diseases, while insulin was shown to exacerbate lung diseases; this suggests that their effects extend beyond their hypoglycemic properties.Keywords: diabetes · asthma · chronic obstructive pulmonary disease · COPD · idiopathic pulmonary fibrosis · pulmonary hypertension · lung cancer · hypoglycemic drugs

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Section: Clinical Presentationmentioning

confidence: 99%

Diabetes and Lung Disease: An Underestimated Relationship

Khateeb

Fuchs

Khamaisi

2019

Review of Diabetic Studies

123

View full text Add to dashboard Cite

show abstract

“…Case selection was similar to that described for previous studies [15][16][17][18]. Mayo Clinic Institutional Review Board approval was obtained for this retrospective, case-control study.…”

Section: Case Selectionmentioning

confidence: 99%

Survival and glycemic control in patients with colorectal cancer and diabetes mellitus.

Karlin

Amin

Verona

et al. 2018

JCO

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The impact of diabetes mellitus (DM) on survival in patients with colorectal cancer and the impact of colorectal cancer on glycemic control were examined. Materials & methods: Patients with colorectal cancer with and without DM were matched 1:1 (2007-2015). Characteristics were compared between the two groups and survival assessed with the Kaplan-Meier method. Mixed models compared hemoglobin A 1c and glucose levels over time. Results: In both groups, glucose values decreased during the year following cancer diagnosis (p < 0.001). 5-year overall survival was 56% (95% CI: 42-68%) for DM patients versus 57% (95% CI: 43-69%) for non-DM patients (p = 0.62). Conclusion: DM did not adversely impact survival of patients with colorectal cancer. Colorectal cancer did not affect glycemic control.

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Section: Clinical Presentationmentioning

confidence: 99%

Diabetes and Lung Disease: A Neglected Relationship

Khateeb¹,

Fuchs²,

Khamaisi³

2018

Rev Diabet Stud

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BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and oxidative stress which may target many organs such as the kidney, retina, and the vascular system. The pathophysiology, mechanisms, and consequences of diabetes on these organs have been studied widely. However, no work has been done on the concept of the lung as a target organ for diabetes and its implications for lung diseases. AIM: In this review, we aimed to investigate the effects of diabetes and hypoglycemic agent on lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, and lung cancer. We also reviewed the potential mechanisms by which these effects may affect lung disease patients. RESULTS: Our results suggest that diabetes can affect the severity and clinical course of several lung diseases. CONCLUSIONS: Although the diabetes-lung association is epidemiologically and clinically well-established, especially in asthma, the underlying mechanism and pathophysiology are not been fully understood. Several mechanisms have been suggested, mainly associated with the proinflammatory and proliferative properties of diabetes, but also in relation to micro-and macrovascular effects of diabetes on the pulmonary vasculature. Also, hypoglycemic drugs may influence lung diseases in different ways. For example, metformin was considered a potential therapeutic agent in lung diseases, while insulin was shown to exacerbate lung diseases; this suggests that their effects extend beyond their hypoglycemic properties.

show abstract

Patient Outcomes from Lung Cancer and Diabetes Mellitus: A Matched Case–Control Study

Cited by 31 publications

References 23 publications

Diabetes and Lung Disease: An Underestimated Relationship

Diabetes and Lung Disease: An Underestimated Relationship

Survival and glycemic control in patients with colorectal cancer and diabetes mellitus.

Diabetes and Lung Disease: A Neglected Relationship

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