Patient ethnicity and causative species determine the manifestations of anti-interferon-gamma autoantibody-associated nontuberculous mycobacterial disease: a review

Hase, Isano; Morimoto, Kozo; Sakagami, Takuro; Ishii, Yoshiki; Ingen, Jakko van

doi:10.1016/j.diagmicrobio.2017.05.011

Cited by 33 publications

(55 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first reports showing a conclusive association to infection with severe atypical mycobacteriosis where published in 2004 [6,7]. Several hundred cases had been described worldwide between 2004 and 2016 [8 ▪▪ ]. Browne et al published a large series of 80 patients with high titre neutralizing anti interferon gamma autoantibodies (nAIGA), thus establishing autoimmune acquired IFN-γ deficiency as a syndrome of a secondary adult-onset immunodeficiency with disseminated mainly nontuberculous mycobacterial infections.…”

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

“…Hase et al [8 ▪▪ ] performed a comprehensive retrospective analysis of 35 studies describing 111 patients with AIGA-associated NTM infections between 2004 and 2016. They calculated a mean age of onset of 52 years (range 15–87).…”

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

“…Lymphnodes were the most frequent site of infection (79%) in contrast to AIDS associated disseminate MAC presenting mostly as bacteremia. Based on own and previous studies using Rituximab, Hase et al [8 ▪▪ ] and Koizumi et al [17 ▪ ] concluded that Rituximab in addition to antimycobacterials chemotherapy could be a treatment option in refractory cases. Hase et al [8 ▪▪ ] and Aoki et al [18 ▪▪ ] emphasised the importance of long-term antibiotic therapies to prevent relapses, with Mycobacterium abscessus posing a particular problem.…”

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

“…Based on own and previous studies using Rituximab, Hase et al [8 ▪▪ ] and Koizumi et al [17 ▪ ] concluded that Rituximab in addition to antimycobacterials chemotherapy could be a treatment option in refractory cases. Hase et al [8 ▪▪ ] and Aoki et al [18 ▪▪ ] emphasised the importance of long-term antibiotic therapies to prevent relapses, with Mycobacterium abscessus posing a particular problem. Baerlecken et al [19], successfully treated a patient with a combination of Plasmaspheresis and pulsed cyclophosphamide.…”

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

See 3 more Smart Citations

Anticytokine autoantibodies leading to infection: early recognition, diagnosis and treatment options

Barcenas-Morales

Cortes-Acevedo

Döffinger

2019

Current Opinion in Infectious Diseases

View full text Add to dashboard Cite

Purpose of review The current review gives a concise and updated overview of the relative new field of anticytokine autoantibodies (ACAA) and associated infections with a focus on recent findings regarding clinical manifestions, diagnostic and treatments. Recent findings Several recent case reports of unusual presentations of patients with neutralizing autoantibodies to IFN-γ and granulocyt macrophage colony-stimulating factor and expand the spectrum of clinical manifestations and suggest that anticytokine-mediated acquired immunodeficiency causing susceptibility to infection may be underdiagnosed. There is an expanding geographical distribution of antigranulocyt macrophage colony-stimulating factor associated Cryptococcus gattii infection. The spectrum of identified infections in patients with neutralizing antibodies to IFN-γ has a strong endemic component. Rituximab or cyclophophamide in addition to antimycobacterials could be a treatment options in refractory cases. NF-κB2 deficiency may be associated with a complex pattern of high titre neutralizing ACAA similar to autoimmune polyglandular syndrome type I and Thymoma. New technique for the detection of anticytokine antibodies are presented. Quantiferon testing, which is widely available for TB-diagnostic, may be repurposed to detect anti-IFN-γ autoantibodies. We propose that this test could be as well used to show if they are neutralizing. Summary ACAA are an emerging cause of acquired immunodeficiency which is likely underdiagnosed. Recent case reports document expanding spectra of clinical manifestations. NF-κB2 deficiency may be associated with a complex anti cytokine autoantibody pattern.

show abstract

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

Section: Autoantibodies To Ifn-γ Cause Susceptibility To Opportunistimentioning

confidence: 99%

See 2 more Smart Citations

Anticytokine autoantibodies leading to infection: early recognition, diagnosis and treatment options

Barcenas-Morales

Cortes-Acevedo

Döffinger

2019

Current Opinion in Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Patients affected by "Adult-onset immunodeficiency with susceptibility to mycobacteria", belong to the category "Phenocopies of inborn errors of immunity", produce autoantibodies against IFN-γ and have increased susceptibility to NTM [84,[98][99][100][101][102][103][104][105][106][107][108].…”

Section: Immunodeficienciesmentioning

confidence: 99%

Pulmonary non-tuberculous mycobacterial infections: current state and future management

Chin

Sarmiento

Alvarez-Cabrera

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Currently, there is a trend of increasing incidence in pulmonary non-tuberculous mycobacterial infections (PNTM) together with a decrease in tuberculosis (TB) incidence, particularly in developed countries. The prevalence of PNTM in underdeveloped and developing countries remains unclear as there is still a lack of detection methods that could clearly diagnose PNTM applicable in these low-resource settings. Since non-tuberculous mycobacteria (NTM) are environmental pathogens, the vicinity favouring host-pathogen interactions is known as important predisposing factor for PNTM. The ongoing changes in world population, as well as socio-political and economic factors, are linked to the rise in the incidence of PNTM. Development is an important factor for the improvement of population well-being, but it has also been linked, in general, to detrimental environmental consequences, including the rise of emergent (usually neglected) infectious diseases, such as PNTM. The rise of neglected PNTM infections requires the expansion of the current efforts on the development of diagnostics, therapies and vaccines for mycobacterial diseases, which at present, are mainly focused on TB. This review discuss the current situation of PNTM and its predisposing factors, as well as the efforts and challenges for their control.

show abstract

A patient with positive anti‐IFN‐γ autoantibody and monoclonal gammaglobulinemia masquerading as multiple myeloma: Case report and literature review

An,

Liu,

Luo

et al. 2024

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical MessageAdult‐onset immunodeficiency (AOID) is an emerging acquired immunodeficiency, characterized by multiple opportunistic infections including non‐tuberculous mycobacterium (NTM) due to the presence of anti‐IFN‐γ autoantibody (AIGA). This case highlights the challenges of accurate diagnosis of monoclonal gammaglobulinemia with NTM infection and favorable outcomes of anti‐plasma cell therapy in AOID.AbstractAdult‐onset immunodeficiency (AOID) is an emerging acquired immunodeficiency due to anti‐IFN‐γ autoantibody (AIGA) with low morbidity, frequent disseminated infections, a prolonged course, difficult diagnosis and treatment, and a poor prognosis. Here, we report a patient with positive AIGA and monoclonal gammaglobulinemia who was mimicking symptomatic multiple myeloma and resulting in a non‐tuberculous mycobacterial (NTM) infection. While he achieved an excellent therapeutic effect with anti‐plasma cell therapy, it also serves as a warning that monoclonal gammaglobulinemia with NTM infection is easily misdiagnosed as symptomatic multiple myeloma, and the screening for AIGA should not be ignored in patients with NTM infection.

show abstract

Patient ethnicity and causative species determine the manifestations of anti-interferon-gamma autoantibody-associated nontuberculous mycobacterial disease: a review

Cited by 33 publications

References 39 publications

Anticytokine autoantibodies leading to infection: early recognition, diagnosis and treatment options

Anticytokine autoantibodies leading to infection: early recognition, diagnosis and treatment options

Pulmonary non-tuberculous mycobacterial infections: current state and future management

A patient with positive anti‐IFN‐γ autoantibody and monoclonal gammaglobulinemia masquerading as multiple myeloma: Case report and literature review

Contact Info

Product

Resources

About