Patient dose evaluation for the whole-body low-dose multidetector CT (WBLDMDCT) skeleton study in multiple myeloma (MM)

Cretti, Fabiola; Perugini, Giovanna

doi:10.1007/s11547-015-0573-6

Cited by 25 publications

(13 citation statements)

References 27 publications

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“…In general, it is recommended to perform a whole body low dose multi-detector CT; doses as low as 3.2-4.8 mSv have been reported to be sufficient. In comparison, radiation dose of CSS is usually 1.2-2.4 mSv (11,(15)(16)(17). Recently, an expert group consisting of radiologists and hematologists has analyzed data on this topic to provide further recommendations (18).…”

Section: Replacement Of Conventional Skeletal Survey By Wbctmentioning

confidence: 99%

International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders

Hillengaß

Usmani

Rajkumar

et al. 2019

The Lancet Oncology

335

330

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Recent advances in the treatment of multiple myeloma (MM) have increased the need for accurate diagnosis of the disease. The detection of bone and bone marrow lesions is crucial in the work-up of MM, and often dictates the decision to start treatment. Furthermore, detection of minimal residual disease (MRD) is important for prognosis and treatment planning, and has underscored an unmet need for sensitive imaging modalities that accurately assess response to therapy in MM. Low dose whole body computed tomography (WBCT) has increased sensitivity compared to conventional skeletal survey (CSS) in the detection of bone disease, and can reveal information leading to changes in therapy and management that could prevent or delay the onset of significant morbidity and mortality related to skeletal-related events. Given the multiple options for detection of bone and bone marrow lesions ranging from CSS to WBCT, positron emission tomography (PET)-CT, and magnetic resonance imaging (MRI), the International Myeloma Working Group has established guidelines on the optimal and standardized use of imaging modalities in different stages of the disease. These recommendations on imaging within and outside of clinical trials will help to standardize the imaging worldwide in order to allow comparison of results and unification of treatment approaches.

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Section: Replacement Of Conventional Skeletal Survey By Wbctmentioning

confidence: 99%

International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders

Hillengaß

Usmani

Rajkumar

et al. 2019

The Lancet Oncology

335

330

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“…4 Most recent studies, instead, employes a 120 kV protocol and a tube current between 30 and 100 mAs, to achieve an effective dose ranging between 2.7 mSv 9 and 29,5 mSv. 4,6 -10,12 -18,21 -23,25 -32 Other studies have been focused on a different approach based on low tube voltage (80 kV) and high current (200–230 mAs), generating an effective dose of about 4.5 mSv. 14…”

Section: Discussionmentioning

confidence: 99%

Whole Body Low Dose Computed Tomography Using Third-Generation Dual-Source Multidetector With Spectral Shaping: Protocol Optimization and Literature Review

et al. 2020

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For decades, the main imaging tool for multiple myeloma (MM) patient’s management has been the conventional skeleton survey. In 2014 international myeloma working group defined the advantages of the whole-body low dose computed tomography (WBLDCT) as a gold standard, among imaging modalities, for bone disease assessment and subsequently implemented this technique in the MM diagnostic workflow. The aim of this study is to investigate, in a group of 30 patients with a new diagnosis of MM, the radiation dose (CT dose index, dose-length product, effective dose), the subjective image quality score and osseous/extra-osseous findings rate with a modified WBLDCT protocol. Spectral shaping and third-generation dual-source multidetector CT scanner was used for the assessment of osteolytic lesions due to MM, and the dose exposure was compared with the literature findings reported until 2020. Mean radiation dose parameters were reported as follows: CT dose index 0.3 ± 0.1 mGy, Dose-Length Product 52.0 ± 22.5 mGy*cm, effective dose 0.44 ± 0.19 mSv. Subjective image quality was good/excellent in all subjects. 11/30 patients showed osteolytic lesions, with a percentage of extra-osseous findings detected in 9/30 patients. Our data confirmed the advantages of WBLDCT in the diagnosis of patients with MM, reporting an effective dose for our protocol as the lowest among previous literature findings.

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“…Die Strahlenexposition einer solchen Untersuchung beträgt ca. 3-5 mSv, was dem 2-bis 3-Fachen eines konventionellen "Pariser Schemas" entspricht [13][14][15]. Angesichts der deutlich höheren Sensitivität und des verbesserten Patientenkomforts in der meist älteren Patientenpopulation ist die gering höhere Strahlenexposition vertretbar.…”

Section: Ganzkörper-ctunclassified

Bildgebende Diagnostik des Multiplen Myeloms

2020

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Hintergrund Das Multiple Myelom ist eine maligne hämatologische Erkrankung, die sich durch die Proliferation von monoklonalen Plasmazellen vor allem im Knochenmark auszeichnet. Die Bildgebung spielt zur Diagnosestellung und Verlaufsbeurteilung eine wichtige Rolle. Methode Dieser Übersichtsartikel informiert über das Krankheitsbild des Multiplen Myeloms samt Vorstufen und beschreibt die zur Verfügung stehenden bildgebenden Untersuchungstechniken. Diese werden samt Vor- und Nachteilen sowie möglichen prognostischen und therapeutischen Implikationen vor dem Hintergrund der aktuellen Literatur vorgestellt. Ergebnisse und Schlussfolgerung Der konventionelle Röntgenstatus ist beim Multiplen Myelom mittlerweile vollständig von Schnittbildtechniken ersetzt worden. Die breit verfügbare Ganzkörper-Computertomografie wird routinemäßig verwendet, um Osteolysen nachzuweisen. Die Magnetresonanztomografie hat die höchste Sensitivität zur Detektion von Knochenmarkbefall und wird insbesondere bei den Vorstufen des symptomatischen Multiplen Myeloms empfohlen. Die Positronen-Emissions-Tomografie vereint morphologische und funktionelle Bildgebung. Sie kommt vor allem bei der Verlaufsbeurteilung und Evaluation von Therapieansprechen zum Einsatz. Kernaussagen:

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Patient dose evaluation for the whole-body low-dose multidetector CT (WBLDMDCT) skeleton study in multiple myeloma (MM)

Cited by 25 publications

References 27 publications

International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders

International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders

Whole Body Low Dose Computed Tomography Using Third-Generation Dual-Source Multidetector With Spectral Shaping: Protocol Optimization and Literature Review

Bildgebende Diagnostik des Multiplen Myeloms

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