Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

Wensink, G. Emerens; Elias, Sjoerd G.; Mullenders, Jasper; Koopman, Miriam; Boj, Sylvia F.; Kranenburg, Onno; Roodhart, Jeanine M.L.

doi:10.1038/s41698-021-00168-1

Cited by 152 publications

(143 citation statements)

References 53 publications

(185 reference statements)

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…As in other diseases like cancer, gerontologists are largely unable to predict treatment response for individual patients, resulting in patients receiving ineffective treatment with unnecessary exposure to toxic side effects and high treatment costs. Effective predictive biomarkers are needed to enable personalized medicine and increase survival for patients [ 73 ]. Personalized medicine strategies include protein-based, RNA-based, and genome-based stratification, though in oncology, precision medicine has been largely based on genomic biomarkers [ 74 ].…”

Section: Precision Medicine: Using Organoids Systems As a Tool To Screen Anti-aging Drugs/ Patient-specific Drug Testingmentioning

confidence: 99%

“…A promising predictive biomarker is individualized tumor response testing using PDOs, in which anticancer agents are screened ex vivo on PDOs to predict the clinical response. PDOs represent a superior preclinical model system compared to previous models through their inherent heterogeneity, long-term stability, applicability for high throughput screens, and enhanced capacity to capture tumor characteristics [ 73 , 74 ].…”

Section: Precision Medicine: Using Organoids Systems As a Tool To Screen Anti-aging Drugs/ Patient-specific Drug Testingmentioning

confidence: 99%

See 1 more Smart Citation

Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids

Torrens‐Mas

Perelló-Reus

Navas-Enamorado

et al. 2021

IJMS

View full text Add to dashboard Cite

The biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast, Caenorhabditis elegans, and cell cultures. Thus, it is unclear to what extent this knowledge is transferable to humans since they might not reflect the complexity of aging in people. An organoid culture is an in vitro 3D cell-culture technology that reproduces the physiological and cellular composition of the tissues and/or organs. This technology is being used in the cancer field to predict the response of a patient-derived tumor to a certain drug or treatment serving as patient stratification and drug-guidance approaches. Modeling aging with patient-derived organoids has a tremendous potential as a preclinical model tool to discover new biomarkers of aging, to predict adverse outcomes during aging, and to design personalized approaches for the prevention and treatment of aging-related diseases and geriatric syndromes. This could represent a novel approach to study chronological and/or biological aging, paving the way to personalized interventions targeting the biology of aging.

show abstract

Section: Precision Medicine: Using Organoids Systems As a Tool To Screen Anti-aging Drugs/ Patient-specific Drug Testingmentioning

confidence: 99%

Section: Precision Medicine: Using Organoids Systems As a Tool To Screen Anti-aging Drugs/ Patient-specific Drug Testingmentioning

confidence: 99%

Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids

Torrens‐Mas

Perelló-Reus

Navas-Enamorado

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…They offer a valuable opportunity to screen for individualized therapeutic options, to test treatment efficacy in advance to setting up patient's therapeutic scheme and to analyze potential resistance mechanisms [65,66]. Therefore, PDOs may advance personalized medicine by predicting the clinical response of individual patients to antitumor agents.…”

Section: Organoids As An Enhanced Model For (Personalized) Drug Screeningmentioning

confidence: 99%

“…To generate an overview of the current evidence on transferability of cancer organoid treatment results to the clinical setting, Verduin et al and Wensink et al conducted (systematic) reviews on the predictive value of tumor organoids [66,99]. Wensink et al showed that 5 out of 17 studies included in their systematic review reported a statistically significant correlation and/or predictive value and 11/17 at least a trend for a correlation or predictive value [66]. Three studies did not find a relation between PDO and patients response and one study was unable to analyze this readout.…”

Section: Organoids As a Promising Tool For The Improvement Of Therapy Efficiency Predictionmentioning

confidence: 99%

Organoid Models for Cancer Research—From Bed to Bench Side and Back

Kastner

Hendricks

Deinlein

et al. 2021

Cancers

View full text Add to dashboard Cite

Organoids are a new 3D ex vivo culture system that have been applied in various fields of biomedical research. First isolated from the murine small intestine, they have since been established from a wide range of organs and tissues, both in healthy and diseased states. Organoids genetically, functionally and phenotypically retain the characteristics of their tissue of origin even after multiple passages, making them a valuable tool in studying various physiologic and pathophysiologic processes. The finding that organoids can also be established from tumor tissue or can be engineered to recapitulate tumor tissue has dramatically increased their use in cancer research. In this review, we discuss the potential of organoids to close the gap between preclinical in vitro and in vivo models as well as clinical trials in cancer research focusing on drug investigation and development.

show abstract

“…As in other diseases like cancer, gerontologists are largely unable to predict treatment response for individual patients, resulting in patients receiving ineffective treatment with unnecessary exposure to toxic side effects and high treatment costs. Effective predictive biomarkers are needed to enable personalized medicine and increase survival for patients [73]. Personalized medicine strategies include protein-, RNA-based and genome-based stratification, though in oncology, precision medicine has been largely based on genomic biomarkers [74].…”

Section: Precision Medicine: Using Organoids Systems As a Tool To Screening Anti-aging Drugs/ Patient-specific Drug Testingmentioning

confidence: 99%

Organoids: An Emerging Tool To Study Aging Signature Across Human Tissues. Modeling Aging With Patient-derived Organoids

Torrens‐Mas¹,

Perelló-Reus²,

Navas-Enamorado³

et al. 2021

Preprint

View full text Add to dashboard Cite

The biology of aging is focused on the identification of novel pathways that regulate the underlying processes of aging to develop interventions aimed at delaying the onset and progression of chronic diseases to extend lifespan. However, the research on the aging field has been conducted mainly in animal models, yeast, Caenorhabditis elegans and cell culture. Thus, it is unclear to what extent this knowledge is transferable to humans since they might not reflect the complexity of aging in people. Organoid culture is an in vitro 3D cell-culture technology that reproduces the physiological and cellular composition of the tissues and/or organs. This technology is being used in the cancer field to predict the response of a patient-derived tumor to a certain drug or treatment serving as patient stratification and drug-guidance approaches. Modeling aging with patient-derived organoids has a tremendous potential as a preclinical model tool to discover new biomarkers of aging, to predict adverse outcomes during aging and to design personalized approaches for prevention and treatment of aging-related diseases and geriatric syndromes. This could represent a novel approach to study chronological and/or biological aging paving the way to personalized interventions targeting the biology of aging.

show abstract

Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

Cited by 152 publications

References 53 publications

Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids

Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids

Organoid Models for Cancer Research—From Bed to Bench Side and Back

Organoids: An Emerging Tool To Study Aging Signature Across Human Tissues. Modeling Aging With Patient-derived Organoids

Contact Info

Product

Resources

About