Patient-Centered Research Priorities for Pulmonary Nontuberculous Mycobacteria (NTM) Infection. An NTM Research Consortium Workshop Report

Henkle, Emily; Aksamit, Timothy R.; Barker, Alan F.; Daley, Charles L.; Griffith, David E.; Leitman, Philip; Leitman, Amy; Malanga, Elisha; Marras, Theodore K.; Olivier, Kenneth N.; Prevots, D. Rebecca; Prieto, Delia; Quittner, Alexandra L.; Skach, William R.; Walsh, John; Winthrop, Kevin

doi:10.1513/annalsats.201605-387ws

Cited by 57 publications

(48 citation statements)

References 33 publications

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“…Firstly, the recent emergence of person-toperson transmission of highly antibiotic resistant MABS across continents is highly alarming (11). These findings have led to new infection control practices in the US, UK, and Australia (34,55,112). Secondly, evidence suggests there is increasing incidence of childhood NTM disease.…”

Section: Recent Developments and Research Prioritiesmentioning

confidence: 99%

“…Research priorities recommended in the US and UK include rapid diagnostic tools fast identification of infecting species (34) and simple and cheap screening tool to identify patients at risk (83,98,112). These are considered high impact research goals that would alert clinicians to at risk patients enabling faster initiation of appropriate treatment and ultimately, superior care.…”

Section: Recent Developments and Research Prioritiesmentioning

confidence: 99%

See 1 more Smart Citation

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

et al. 2020

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Section: Recent Developments and Research Prioritiesmentioning

confidence: 99%

Section: Recent Developments and Research Prioritiesmentioning

confidence: 99%

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

et al. 2020

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“…Journal publications. These areas were identified by a NTM Research Consortium Workshop as some of the main priorities for patient-centred research clinical and translational science (44).…”

Section: Non-tuberculous Mycobacteriamentioning

confidence: 99%

Update in Tuberculosis and Nontuberculous Mycobacteria 2017

Abubakar¹,

Rk²,

Rangaka³

et al. 2018

Am J Respir Crit Care Med

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“…However, older adults and immunocompromised persons like HIV-infected persons are at more risk of the infection 10,20. NTM infections present similar clinical and radiographic manifestations like those of pulmonary TB,7,21 hence resulting false in positives in both smear and culture.…”

Section: Discussionmentioning

confidence: 99%

Assessment of sputum smear-positive but culture-negative results among newly diagnosed pulmonary tuberculosis patients in Tanzania

Mnyambwa

Ngadaya

Kimaro

et al. 2017

IJGM

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Diagnosis of pulmonary tuberculosis (TB) in technology-limited countries is widely achieved by smear microscopy, which has limited sensitivity and specificity. The frequency and clinical implication of smear-positive but culture-negative among presumptive TB patients remains unclear. A cross-sectional substudy was conducted which aimed to identify the proportion of nontuberculous mycobacteria (NTM) infections among 94 “smear-positive culture-negative” patients diagnosed between January 2013 and June 2016 in selected health facilities in Tanzania. Out of 94 sputa, 25 (26.60%) were GeneXpert® mycobacteria TB positive and 11/94 (11.70%) repeat-culture positive; 5 were Capilia TB-Neo positive and confirmed by GenoType MTBC to be Mycobacterium tuberculosis/Mycobacterium canettii. The remaining 6 Capilia TB-Neo negative samples were genotyped by GenoType® CM/AS, identifying 3 (3.19%) NTM, 2 Gram positive bacteria, and 1 isolate testing negative, together, making a total of 6/94 (6.38%) confirmed false smear-positives. Twenty-eight (29.79%) were confirmed TB cases, while 60 (63.83%) remained unconfirmed cases. Out of 6 (6.38%) patients who were HIV positive, 2 patients were possibly coinfected with mycobacteria. The isolation of NTM and other bacteria among smear-positive culture-negative samples and the presence of over two third of unconfirmed TB cases emphasize the need of both advanced differential TB diagnostic techniques and good clinical laboratory practices to avoid unnecessary administration of anti-TB drugs.

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Patient-Centered Research Priorities for Pulmonary Nontuberculous Mycobacteria (NTM) Infection. An NTM Research Consortium Workshop Report

Abstract: Nontuberculous mycobacteria (NTM)

Cited by 57 publications

References 33 publications

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

The Rise of Non-Tuberculosis Mycobacterial Lung Disease

Update in Tuberculosis and Nontuberculous Mycobacteria 2017

Assessment of sputum smear-positive but culture-negative results among newly diagnosed pulmonary tuberculosis patients in Tanzania

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