“…Although there are no HPC projects within primary care, patient-centered medical homes within primary care assist with the coordination of medical care and increasingly provide direct treatment for MHC, such as anxiety and depression (Asarnow et al, 2017 ). However, research has found that when compared with adolescents without an MHC, those with an MHC are less likely to receive care in a patient-centered medical home (Yonek et al, 2018 ). For youth with multiple mental health comorbidities who are interfacing with several systems simultaneously or sequentially, increased research is needed to determine which settings are best suited to deliver opioid misuse and OUD prevention interventions, the optimal way to deliver these interventions (synchronous in-person or virtual, asynchronous, or independent of an interventionist), as well as what setting should serve as a medical “home” to monitor their response to these interventions over time.…”