Patient Care Outcomes in Hospitalized Patients with Acute Generalized Exanthematous Pustulosis: A Cross-Sectional Database Study

Nusbaum, Kelsey B.; Walker, Trent D.; Himed, Sonia; Trinidad, John; Spaccarelli, Natalie; Chung, Catherine; Kaffenberger, Benjamin H.

doi:10.1007/s40257-022-00737-5

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…We observed known AGEP characteristics, including pustules, older age, higher body mass index, less frequent internal organ (liver) involvement, and increased intertriginous involvement, in patients with DRESS with pustulosis who did not meet AGEP criteria . Although not statistically significant, the data showed an association between the presence of a pustular eruption and frequency of DRESS recurrences, with some patients (n = 3) requiring reinitiation of immunosuppression or taper prolongation.…”

Section: Discussionmentioning

confidence: 71%

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Drug Reaction With Eosinophilia and Systemic Symptoms With Pustulosis

Hansen,

Kirven,

Gallardo

et al. 2024

JAMA Dermatol

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Section: Discussionmentioning

confidence: 71%

“…1,2,4 A subset of patients with DRESS develop a pustular eruption that resembles acute generalized exanthematous pustulosis (AGEP) without meeting full AGEP criteria. [1][2][3][4]6 The features and outcomes of patients with DRESS with pustules are not well described.…”

mentioning

confidence: 99%

Drug Reaction With Eosinophilia and Systemic Symptoms With Pustulosis

Hansen,

Kirven,

Gallardo

et al. 2024

JAMA Dermatol

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“…AGEP has been reported more frequently in women, with a mean age of 56 years [ 8 , 9 ]. AGEP has been associated with increased body mass index; the mechanism may be related to upregulated proinflammatory cytokines secondary to obesity [ 10 , 11 ]. Latency to drug-induced AGEP is a bimodal distribution as evidenced by Table 1 .…”

Section: Epidemiologymentioning

confidence: 99%

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management

et al. 2023

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Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, and drug-induced etiologies. Diagnosis of AGEP depends on both clinical and histologic criteria, as cases of overlap with other disease processes have been reported. Management includes removal of the offending drug or treatment of the underlying cause, if necessary, and supportive care, as AGEP is a self-limited disease. This review aims to provide an overview and update on the epidemiology, pathogenesis, reported precipitating factors, differentials, diagnosis, and management of AGEP.

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Pruritus: An Approach to Diagnosis and Management for the Inpatient Dermatologist

Soares

Yosipovitch

2023

Curr Derm Rep

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Patient Care Outcomes in Hospitalized Patients with Acute Generalized Exanthematous Pustulosis: A Cross-Sectional Database Study

Cited by 4 publications

References 19 publications

Drug Reaction With Eosinophilia and Systemic Symptoms With Pustulosis

Drug Reaction With Eosinophilia and Systemic Symptoms With Pustulosis

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management

Pruritus: An Approach to Diagnosis and Management for the Inpatient Dermatologist

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