“…Pre-operative blood management strategies include supplementation with iron or Procrit, as well as the management of anti-platelet agents. 4 Intra-operative use of TXA has been shown to be successful in mitigating blood loss in several surgical disciplines, 3 though other strategies include the use of tourniquets to reduce blood flow to lower extremities, hypotensive epidural anesthesia, acute normovolemic hemodilution, antifibrinolytic agents, topical fibrin sealants, intraoperative cell salvage, epinephrine containing injections, platelet-rich plasma injections, and sealing the femoral tunnel. 4 As much as 50% of total blood loss in TKA occurs post-operatively, so post-operative strategies include joint compression, cryotherapy, post-operative cell saving, and drain clamping.…”