Patient-Assessed Late Toxicity Rates and Principal Component Analysis After Image-Guided Radiation Therapy for Prostate Cancer

Skala, Marketa; Rosewall, Tara; Dawson, Laura A.; Divanbeigi, Lorella; Lockwood, Gina; Thomas, Christopher G.; Crook, Juanita; Chung, Peter; Warde, Padraig; Catton, Charles

doi:10.1016/j.ijrobp.2006.12.064

Cited by 52 publications

(36 citation statements)

References 23 publications

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“…Thus, the DSH indices in multiples of 5 Gy were used to produce uncorrelated principal components which account for most of the variances in smaller dimensions. Applications of this dimensional reduction method has been shown in previous dose-response studies [22,23].…”

Section: Principal Components Of Bladder Dose-surface Histogrammentioning

confidence: 94%

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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Urinary symptoms (frequency, incontinence, dysuria and haematuria) were prospectively assessed using LENT-SOMA to a median of 72 months. The endpoints assessed were prevalence (grade≥1) at the end of radiotherapy (representing acute symptoms), at 18-, 36-and 54-month follow-ups (representing late symptoms) and peak late incidence including only grade≥2. Impact of factors were assessed using multivariate logistic regression models with correction for over-optimism. Results: Baseline symptoms, non-insulin dependent diabetes mellitus, age and PC1 (correlated to the mean dose) impact symptoms at >1 timepoints. Associations at a single timepoint were found for cerebrovascular condition, ECOG status and non-steroidal anti-inflammatory drug intake. Peak incidence analysis shows the impact of baseline, bowel and cerebrovascular condition and smoking status. Conclusions:The prevalence and incidence analysis provide a complementary view for urinary symptom prediction. Sustained impacts across time points were found for several factors while some associations were not repeated at different time points suggesting poorer or transient impact.4

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Section: Principal Components Of Bladder Dose-surface Histogrammentioning

confidence: 94%

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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“…The response rate to our questionnaire was 64.5% and is in keeping with other questionnaire-based studies of prostate cancer treatment outcomes. [24][25][26][27] The impact of combined surgery and radiotherapy on health-related quality of life has not been extensively investigated. The only randomized data is from Moinpour and …”

Section: Discussionmentioning

confidence: 99%

Treatment-related toxicity and symptom-related bother followingpostoperative radiotherapy for prostate cancer

Sia

Rodrigues²,

Ménard

et al. 2013

CUAJ

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Introduction: Patients have reported late effects and symptom-related bother following postoperative radiotherapy for prostate cancer. Methods:Patients treated with postoperative radiotherapy were surveyed at a median 56 months after radiotherapy using the Prostate Cancer Radiation Therapy instrument. A retrospective review was undertaken to obtain Radiation Therapy Oncology Group-Late Effects Normal Tissue (RTOG-LENT) toxicity scores at baseline and during follow-up.

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“…22,23 However, PCA cannot be readily applied when the cohort consists of several different radiotherapy techniques owing to the variability in the dose distributions. 23 We have therefore not applied PCA in the present study.…”

Section: Introductionmentioning

confidence: 99%

Parametrized rectal dose and associations with late toxicity in prostate cancer radiotherapy

Hamlett

McPartlin

Maile

et al. 2015

BJR

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Patient-Assessed Late Toxicity Rates and Principal Component Analysis After Image-Guided Radiation Therapy for Prostate Cancer

Cited by 52 publications

References 23 publications

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Treatment-related toxicity and symptom-related bother followingpostoperative radiotherapy for prostate cancer

Parametrized rectal dose and associations with late toxicity in prostate cancer radiotherapy

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