Pathways to post‐traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults

Viteri, Stacey Subbie‐Saenz de; Pandey, Ashwini K.; Pandey, Gayathri; Kamarajan, Chella; Smith, Rebecca L.; Anokhin, Andrey P.; Bauer, Lance O.; Bender, Annah K.; Chan, Grace; Dick, Danielle M.; Edenberg, Howard J.; Kinreich, Sivan; Kramer, John; Schuckit, Marc A.; Zang, Yong; Bucholz, Kathleen K.; Porjesz, Bernice; Meyers, Jacquelyn L.

doi:10.1002/brb3.1789

Cited by 12 publications

(12 citation statements)

References 78 publications

(162 reference statements)

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“…Young adults with exposure to non-sexual assaultive trauma had less efficient neurocognitive performance (planning and problem solving skills), possibly suggesting frontal lobe deficits. 66,67 • Genetic findings: Individuals with higher AUD PGS demonstrated deficits in neuropsychological performance, including poorer planning and problem solving skills on the Tower of London task. 29 CATs Visual Span Test (VST) b,c…”

Section: Resting State Eegmentioning

confidence: 99%

The collaborative study on the genetics of alcoholism: Brain function

Meyers,

Brislin,

Kamarajan

et al. 2023

Genes Brain and Behavior

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Alcohol use disorder (AUD) and related health conditions result from a complex interaction of genetic, neural and environmental factors, with differential impacts across the lifespan. From its inception, the Collaborative Study on the Genetics of Alcoholism (COGA) has focused on the importance of brain function as it relates to the risk and consequences of alcohol use and AUD, through the examination of noninvasively recorded brain electrical activity and neuropsychological tests. COGA's sophisticated neurophysiological and neuropsychological measures, together with rich longitudinal, multi‐modal family data, have allowed us to disentangle brain‐related risk and resilience factors from the consequences of prolonged and heavy alcohol use in the context of genomic and social‐environmental influences over the lifespan. COGA has led the field in identifying genetic variation associated with brain functioning, which has advanced the understanding of how genomic risk affects AUD and related disorders. To date, the COGA study has amassed brain function data on over 9871 participants, 7837 with data at more than one time point, and with notable diversity in terms of age (from 7 to 97), gender (52% female), and self‐reported race and ethnicity (28% Black, 9% Hispanic). These data are available to the research community through several mechanisms, including directly through the NIAAA, through dbGAP, and in collaboration with COGA investigators. In this review, we provide an overview of COGA's data collection methods and specific brain function measures assessed, and showcase the utility, significance, and contributions these data have made to our understanding of AUD and related disorders, highlighting COGA research findings.

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Section: Resting State Eegmentioning

confidence: 99%

The collaborative study on the genetics of alcoholism: Brain function

Meyers,

Brislin,

Kamarajan

et al. 2023

Genes Brain and Behavior

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“…Beginning in 2004 and following additional Human Subjects' Protections Committees approvals, the COGA Prospective Study began by enrolling 12-to 23-year-old grandchildren, nieces, nephews, and offspring of original subjects (Bucholz et al, 2017;de Viteri et al, 2019). These younger participants were reinterviewed about every 2 years using an SSAGA version that included gathering details regarding the 11 DSM-IV AUD criteria and the single new DSM-5 criterion of craving (American Psychiatric Association, 1994Association, , 2013.…”

Section: The Coga Next Generations Prospective Studymentioning

confidence: 99%

Changes over time in endorsement of 11 DSM‐IV alcohol use disorder (AUD) criteria in young adults with persistent or recurrent AUD in The Collaborative Study on the Genetics of Alcoholism

Schuckit

Smith

Danko

et al. 2023

Alcohol: Clinical and Experimental Research

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Background Endorsement of specific Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM‐IV) alcohol use disorder (AUD) criteria have been shown to change significantly over time in men in their thirties who have persistent or recurrent AUD. However, few studies have documented whether the endorsement of AUD items changes over time in younger individuals or in women. We evaluated changes in the endorsement of AUD criteria in 377 men and women with persistent or recurrent AUD during their twenties. Methods Information on AUD‐item endorsement over time was available for 223 men and 154 women aged 20‐25 with persistent or recurrent AUD in at least three interviews in the Collaborative Study on the Genetics of Alcoholism. The statistical significance of endorsement changes over time was evaluated using the related‐sample Cochran's Q test for the full sample and for men and women separately. Additional analyses evaluated sex differences in the patterns of change. Results In the full sample, the predominant pattern was for a significant increase in the rates of endorsement for six of the seven alcohol dependence criteria but not in the four abuse criteria. A similar pattern was seen within men, but women had significant changes in only three of the seven dependence criteria. Conclusions Endorsement of the seven alcohol dependence criteria among individuals with persistent or recurrent AUD in their twenties generally increased, but few changes were observed in the rates of endorsement of the four abuse criteria. These results are discussed in terms of how they reflect on the nature of AUD and the DSM criteria.

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“…Ovde se takođe može implementirati hipoteza samomedikacije, prema kojoj alkohol služi kao sredstvo za nošenje sa traumom. Druga hipoteza predstavlja model podeljene odgovornosti, prema kojoj posttraumatski stresni poremećaj i alkoholizam nose zajedničke faktore rizika, kao što su familijarna istorija zavisnosti od alkohola, neurokognitivna i bihevioralna oštećenja, te genetski rizik (13).…”

Section: Uvodunclassified

Depression, anxiety and stress among alcohol addicts

Barać¹,

Gutić²,

Vukčević³

et al. 2022

Medicinski časopis

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Objective. The aim of the study was to examine the level of depression, anxiety and stress in alcohol addicts, i.e. to determine differences in the level of depression, anxiety and stress between the group of subjects diagnosed with F10.1 and the group of subjects diagnosed with F10.2, as well as to determine differences in sociodemographic characteristics and health status between the groups of subjects diagnosed with F10.1 and F10.2. Methods. Our study was designed as a non-experimental, observational cross-sectional study. It was conducted at the University Clinical Centre Kragujevac in the Clinic for Psychiatry, during January 2021. The sample consisted of 110 respondents of both sexes, aged 18 to 65, divided into two groups. The first group consisted of subjects diagnosed with alcohol dependence (F10.2), and the second group consisted of subjects diagnosed with alcohol abuse (F10.1). Results. Our study has shown that alcohol addicts have clinically significant and severe symptoms of depression, that symptoms were positively correlated with stress levels, and that short-term stress of milder intensity was associated with occasional alcohol abuse, while prolonged stress was a predictor of alcohol dependence. No statistically significant association of alcohol dependence and alcohol abuse with anxiety was found. It was also found that alcohol dependence is associated with certain sociodemographic characteristics such as gender and marital status, education level, employment status, as well as health status and the number of hospitalizations. Conclusion. With this study, we have shown how much stress is present and important in the genesis of alcoholism, as well as the positive correlation of depression and alcohol dependence, and the importance of sociodemographic characteristics in their genesis.

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Pathways to post‐traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 12 publications

References 78 publications

The collaborative study on the genetics of alcoholism: Brain function

The collaborative study on the genetics of alcoholism: Brain function

Changes over time in endorsement of 11 DSM‐IV alcohol use disorder (AUD) criteria in young adults with persistent or recurrent AUD in The Collaborative Study on the Genetics of Alcoholism

Depression, anxiety and stress among alcohol addicts

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