Pathways of metastatic spread in meningiomas

Cucu, Andrei; Turliuc, Dana Mihaela; Costea, Claudia Florida; Costăchescu, B.; Malaimare, Andreea Eliza; Blaj, Laurentiu Andrei; Trandafir, Violeta; Dancă, Cristina; Poeată, I.

doi:10.33962/roneuro-2019-002

Cited by 5 publications

(12 citation statements)

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“…Meningiomas makes up about one third of all primary central nervous system tumours, being the most common brain tumour in adults over the age of 35 (1), with an incidence that has increased in recent years (2,3). As far as Romania is concerned, an increase in the number of intracranial meningiomas was noted in its North-Eastern region (where this research was conducted) over the 1990-2015 period (4).…”

Section: Introductionmentioning

confidence: 84%

Anatomical localization of intracranial grade II meningiomas in North-Eastern Romania

Cucu¹,

Costea²,

Turliuc³

et al. 2019

roneuro

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Objective. Our research aims to assess a possible connection between tumour localization and histological subtypes of grade II meningiomas. Material and methods. 143 patients with grade II WHO meningiomas underwent surgical resection in "Prof. Dr. N. Oblu" Emergency Clinical Hospital Ia?i between 1990 and 2015. The collected data included: patient age, gender, tumour localization and histopathological diagnosis (atypical, clear cells and chordoid meningioma). Results. 135 (94.4%) of all 143 patients with grade II meningiomas were atypical meningiomas, 6 (4.2%) were cell clear meningiomas and only 2 (1.4%) were chordoid meningiomas. As concerns their distribution by gender, 79 (55.2%) were female and 64 (44.8%) were male. Grade II meningiomas were most commonly located at convexity 49.7% (n=71), followed by skull base in 30.8% (n=44) of the cases and parasagittal/falcine in 14.7% (n=21) of the patients. Conclusions. The most common localization of grade II meningiomas was convexity, followed by skull base, parasagittal/falcine and intraventricular areas. We have also noticed that convexity meningiomas are more frequent in women, unlike the other anatomical localizations in which the male-female ratio is almost equal. Therefore, further research is necessary to determine the role of embryological, anatomopathological and genetic factors in underlying the connection between meningioma grade and anatomical localization.

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Section: Introductionmentioning

confidence: 84%

Anatomical localization of intracranial grade II meningiomas in North-Eastern Romania

Cucu¹,

Costea²,

Turliuc³

et al. 2019

roneuro

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“…Metastasis of intracranial meningioma to the liver is extremely rare and its dissemination routes to other organs have not unfortunately been fully understood yet. However, several spread routes have been suggested, namely through the cerebrospinal fluid, venous system or lymphatics; among these, hematogenous spread through the venous system is thought to be the most common [11,14,25].…”

Section:  Pathways Of Metastatic Spread In Meningiomasmentioning

confidence: 99%

“…In extremely rare cases, i.e., 0.1%, intracranial meningiomas can spread extracranial [9], the most common anatomical localizations being the lungs, pleura, mediastinum, axial bones, and lymph nodes [10][11][12][13][14]. Of all these extracranial disseminations of meningiomas, hepatic metastases along with extra-axial bone metastases are even less common [10,12,13].…”

Section:  Introductionmentioning

confidence: 99%

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2022

Rom J Morphol Embryol

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Metastases from intracranial meningiomas are rare, and among them, meningiomas with hepatic dissemination are extremely rare. Therefore, there are currently no guidelines for staging and treatment of metastatic disease in meningioma, a disease that is a challenge for both the clinician and the pathologist. Our literature review revealed 24 cases of liver metastases originating from intracranial meningiomas. We used them to analyze the pathological patterns of dissemination and to assess the different management strategies available, the most efficient and beneficial being surgery and chemotherapy, especially in the case of meningiomas with hepatic and/or systemic dissemination.

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“…They have a 7–8 times higher risk of recurrence [ 13 ] and the median time to progression is about 24 months [ 14 , 15 , 16 ], although some reports have shown tumor progression even within one year of surgery, despite total resection [ 17 ]. Regarding their ability to spread at a distance, most of the time, AMs do not metastasize, although such cases have been reported in the literature [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Predictor factors for recurrence in atypical meningiomas

Cucu,

Costea,

Turliuc

et al. 2023

Rom J Morphol Embryol

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Background and Objectives: Atypical meningiomas (AMs), World Health Organization (WHO) grade 2, are a group of tumors with uneven and unpredictable clinical behavior. Our aim was to analyze possible tumor recurrence predictors, and to identify factors that improve progression-free survival (PFS). Patients, Materials and Methods: Our retrospective study included 81 patients followed up in the Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania, between 1 January 2010 and 31 December 2020. The histopathological specimens were reviewed according to the WHO 2021 criteria. Analyses included clinical, imaging, pathological and surgical factors. Results: The tumor recurred in 53.1% of the 81 cases within 60 months of surgery. Tumor location (p<0.000), tumor volume (p<0.010), extent of surgical resection (p<0.000) and dural sinus invasion (p<0.001) were predictive factors of recurrence. Gross total resection (Simpson grade I and II) was achieved in 59.2% of patients. Patients with the tumors located in the brain convexity and volume <26.4 cm3 had better survival rates up to recurrence. PFS showed a significant relationship between Simpson grade I–III and biopsy (p<0.000) and was statistically influenced by tumor volume and location, and dural sinus invasion. Conclusions: AMs are a heterogeneous group of tumors, and we identified posterior fossa location, volume ≥26.4 cm3, Simpson grade III and IV resection and dural sinus invasion as predictive factors for relapse and a shorter PFS. Whereas certain characteristics provide some prognostic value, future molecular characterizations of AMs are necessary, which will support the clinical decision-making process.

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Pathways of metastatic spread in meningiomas

Cited by 5 publications

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Anatomical localization of intracranial grade II meningiomas in North-Eastern Romania

Anatomical localization of intracranial grade II meningiomas in North-Eastern Romania

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Predictor factors for recurrence in atypical meningiomas

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