Pathways of Cysteine Synthesis in Aspergillus nidulans

Shepherd, C. J.

doi:10.1099/00221287-15-1-29

Cited by 31 publications

(13 citation statements)

References 11 publications

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“…The pathway of cyst(e)ine biosynthesis has previously been studied in a variety of micro-organisms including Escherichia coli (Lampen, (Phinney, 1948; Horowitz, 1950Horowitz, , 1955; AspergiZlus nidulans (Hockenhull, 1949; Shepherd, 1956); A . niger (Steinberg, 1941).…”

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confidence: 99%

Nutritional Studies of Cysteineless Mutants of Salmonella typhimurium

Clowes

1958

Journal of General Microbiology

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SUMMARY : Forty-three separately isolated cyst(e)ineless mutants of Salmonella typhimurium were investigated biochemically. Six main phenotypes were identified, accommodating thirty-nine of the mutants; the remaining four mutants were of intermediate phenotype. The phenotypes are suggested to result from a series of five metabolic blocks in a pathway of cyst(e)ine synthesis in which sulphate can be reduced by two alternative routes, in both of which most of the intermediates are inorganic.In this paper the expression cyst(e)ine is used to represent cysteine or cystine. The pathway of cyst(e)ine biosynthesis has previously been studied in a variety of micro-organisms including Escherichia

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Nutritional Studies of Cysteineless Mutants of Salmonella typhimurium

Clowes

1958

Journal of General Microbiology

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“…It may be noted that in all the previous work with A . nidu2ans (Hockenhull, 1949;Shepherd, 1956) it has been assumed that cysteine is formed from thiosulphate by way of cysteine-S-sulphonate. Although Shepherd (1956) claimed that sulphate sulphur combines with the carbon chain at the sulphite stage in the normal assimilatory metabolism, it does not seem possible to explain the results described either in the present paper or in that of Hockenhull (1949) by assuming such a pathway.…”

Section: Discussionmentioning

confidence: 99%

“…This pathway has been suggested to be operative in Aspergillus nidulans (Shepherd, 1956). The formation in rabbit kidney of radioactive cysteine sulphinate from S5S-labelled sulphite has also been reported (Chapeville & Fromageot, 1954).…”

Section: Introductionmentioning

confidence: 96%

“…It has further been suggested from studies with mutant strains of Aspergillus nidulans that thiosulphate reacts with serine to give cysteine-S-sulphonate as an intermediate in the biosynthesis of cysteine (Hockenhull, 1949). Shepherd (1956) also considered this possibility, but denied the involvement of thiosulphate in the main route of sulphate assimilation.…”

Section: Introductionmentioning

confidence: 99%

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Biochemical Genetical Studies on the Pathway of Sulphate Assimilation in Aspergillus nidulans

Nakamura

1962

Journal of General Microbiology

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“…Powerful techniques for genetic analysis have been developed for the mould Aspergillus nidulans (Pontecorvo et al 1953; Pontecorvo & Kafer, 1958) but relatively little work has been done on the biochemistry of the organism (Hockenhull, 1950; Singh & Walker, 1956) and few attempts made to combine genetical and biochemical investigations (Shepherd, 1956). Following the elucidation of the Leloir pathway of galactose metabolism (reviewed by Kalckar, 1958) genetically determined lesions in the enzymes concerned were described in man (Kalckar, 1959), in Saccharomyces cerevisiae (Robichon-Szulmajster, 1958) and in certain enterobacteria (Kalckar, Kurahashi & Jordan, 1959 ;Fukasawa & Nikaido, 1961 ;Soffer, 1961).…”

Section: Introductionmentioning

confidence: 99%