Pathways of Ca2+ influx at the plasma membrane: Voltage-, receptor-, and second messenger-operated channels

Meldolesi, Jacopo; Pozzan, Tullio

doi:10.1016/0014-4827(87)90161-3

Cited by 221 publications

(53 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a number, and possibly all cell types, the activation of receptors coupled to the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] causes both release of Ca2 ' from intracellular stores and increased Ca2+ influx through the plasma membrane [33]. This latter event is generally thought to involve Ca2+ channels, mostly because the influx of Ca2+ depends on the transmembrane potential, i.e.…”

Section: Cu2+ Smocsmentioning

confidence: 99%

“…(a) ROCs are those channels in which the ligand-binding site and the channel are either on the same polypeptide or in the same molecular complex [33]. Within the group of agonistactivated Ca" channels, Ca" ROCs are by far the best characterized in molecular and electrophysiological terms and incude the nicotinic channel, the N-methyl u-aspartate (MeDAsp) channel and perhaps, the ATP (external) gated channel( s).…”

Section: Receptor-activated and Second-messenger-activtrted Ca2+ Chanmentioning

confidence: 99%

“…(b) The channels that are linked to the receptor via a soluble second messenger belong to a second group, and are termed SMOCs [33]. The Ca2+-activated Ca" channels, found in different cell types, are the prototype of the Ca2+ SMOCs.…”

Section: Receptor-activated and Second-messenger-activtrted Ca2+ Chanmentioning

confidence: 99%

See 2 more Smart Citations

Structural and functional aspects of calcium homeostasis in eukaryotic cells

Pietrobon

Virgilio

Pozzan

1990

European Journal of Biochemistry

Self Cite

203

View full text Add to dashboard Cite

The maintenance of a low cytosolic free-Ca2+ concentration, ([Ca2+Ii) is a common feature of all eukaryotic cells. For this purpose a variety of mechanisms have developed during evolution to ensure the buffering of Ca2+ in the cytoplasm, its extrusion from the cell and/or its accumulation within organelles. Opening of plasma membrane channels or release of Ca2+ from intracellular pools leads to elevation of [Ca2+Ii; as a result, Ca2+ binds to cytosolic proteins which translate the changes in [Ca2+Ii into activation of a number of key cellular functions.The purpose of this review is to provide a comprehensive description of the structural and functional characteristics of the various components of [CaZ+li homeostasis in eukaryotes.It is well known how Sidney Ringer recognized the role of Ca2+ in muscle contraction [l] and how fortunate it was that he was working with frog heart muscle, rather than with skeletal muscle, given that contractility in the latter muscle is basically independent of extracellular Ca2 + . Less appreciated is the fact that it took a century before a wide-range test of the 'Ca2+ hypothesis' in the mediation of cellular responses became possible. So many years in fact elapsed between the publication of the seminal paper by Ringer in 1883 [l] and the report in 1982 by Tsien and co-workers [2] describing the application of quin 2 to the measurement of intracellular free Ca2+ ([Ca2++Ii) in small mammalian cells.The exploitation of fluorescent tetracarboxylate/pentacarboxylate dyes for measuring Ca2 + has enabled a thorough testing of Ca2+ involvement in a host of cellular responses spanning fertilization to muscle contraction, proliferation to neurotransmitter release and cell motility to cell death. The fluorescent dye technique has also complemented biochemistry, electrophysiology and molecular biology, and allowed the description in real time of the actual changes in [Ca2+Ii following the activation of membrane Ca2+ influx/ efflux pathways. Additional levels of complexity have emerged from the application of these techniques to the study of C a 2 + homeostasis and new problems have arisen, yet for the first Correspondewe to T. Pozzan, Institute of General Pathology, University of Ferrara, Via Borsari 46, 1-35121 Ferrara, ItalyAbbreviations. [Ca' +Ii, cytosolic free-Caz + concentration; VOC, voltage-operated channel; ROC, receptor-operated channel ; SMOC, second messenger-operated channcl; GOC, G-protein-operated channel; EC coupling, excitation-contraction coupling; MeDAsp, N-methyl u-aspartate; Ins(1 ,4,5)P3, inositol 1,4,5-trisphosphatc; Ins(1,3,4,5)P4, inositol 1,3,4,5-tetrakisphosphate; PtdIns(4,5)P2, phosphatidylinositol(4,5) bisphosphatc; SR, sarcoplasmic reticulum; ER. endoplasmic reticulum; TC, terminal cisternae; El. enzyme form 1 of ATPase; E2, enzyme form 2 of ATPase; G-protein, guanylnucleotide-binding protein.time we are beginning to understand CaZi signaling as the integration of multiple pathways.Ca" is maintained in the cytoplasm of mammalian cells at a concentration tha...

show abstract

Section: Cu2+ Smocsmentioning

confidence: 99%

Section: Receptor-activated and Second-messenger-activtrted Ca2+ Chanmentioning

confidence: 99%

See 1 more Smart Citation

Structural and functional aspects of calcium homeostasis in eukaryotic cells

Pietrobon

Virgilio

Pozzan

1990

European Journal of Biochemistry

Self Cite

203

View full text Add to dashboard Cite

show abstract

“…The mechanism by which muscarinic receptor occupancy allows Ca2t entry in these cells has been of considerable interest, with G-protein, second messenger, voltage and direct receptor-operated mechanisms being proposed (Meldolesi & Pozzan, 1987;Putney, 1990;Lambert & Nahorski, 1990b). …”

Section: Introductionmentioning

confidence: 99%

Elevation of cytosolic calcium by cholinoceptor agonists in SH‐SY5Y human neuroblastoma cells: estimation of the contribution of voltage‐dependent currents

Forsythe

Lambert

Nahorski

et al. 1992

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…A similar inhibitory effect of TMB 8 on the zymosan-induced release of TxBz, PGE2 and PGD2 from cells prelabeled with [3H]arachidonic acid was observed (data not shown). Verapamil and nifedipine have been reported to inhibit Ca2+ influx from the extracellular space into excitable cells through Ca2 + channels located in the plasma membrane [22]. None of the calcium channel blockers (at a concentration of 100 pM) had a significant effect on the release of PGE2 by rat Kupffer cells after addition of zymosan, phorbol ester, A23187 or arachidonic acid (data not shown).…”

Section: Resultsmentioning

confidence: 88%

Ca²⁺ requirement of prostanoid but not of superoxide production by rat Kupffer cells

Dieter

Schulze‐Specking

Decker

1988

European Journal of Biochemistry

View full text Add to dashboard Cite

The release of the prostanoids prostaglandin D2 (PGDJ, prostaglandin E2 (PGE,) and thromboxane induced by zymosan and phorbol ester in cultured rat Kupffer cells was found to depend on the extracellular concentration of Ca2+ to some extent. Prostanoid formation following the addition of the calcium ionophore A 23187 was totally inhibited when calcium ions were withdrawn from the medium whereas the prostanoid synthesis from added arachidonic acid was independent of Ca2+. A half-maximal rate of PGE, release by cells treated with zymosan, phorbol ester or A23187 was obtained at 0.6-0.7 pM free extracellular Ca2+ and 2 100 pM free Ca2+ was required to stimulate PGE, formation maximally.The calmodulin antagonist R24571 partially inhibited the release of PGEz elicited by zymosan and A23187 but not by phorbol ester or arachidonic acid. Verapamil and nifedipine, two calcium channel blockers, had no effect on the formation of PGE, irrespective of the stimulus. TMB 8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)-octyl ester] an intracellular calcium antagonist, inhibited the synthesis of PGE, induced by zymosan and phorbol ester.The superoxide formation following the addition of zymosan and phorbol ester was not influenced by removal of calcium ions from the medium or by addition of the various calcium antagonists. The data presented here suggest that Ca2+-dependent reactions are involved in the synthesis of prostanoids induced by zymosan and phorbol ester and that both extracellular Ca2+ and mobilization of Ca2+ from intracellular stores are needed to induce maximally the production of prostanoids in cultured rat Kupffer cells.

show abstract

Pathways of Ca2+ influx at the plasma membrane: Voltage-, receptor-, and second messenger-operated channels

Cited by 221 publications

References 71 publications

Structural and functional aspects of calcium homeostasis in eukaryotic cells

Structural and functional aspects of calcium homeostasis in eukaryotic cells

Elevation of cytosolic calcium by cholinoceptor agonists in SH‐SY5Y human neuroblastoma cells: estimation of the contribution of voltage‐dependent currents

Ca²⁺ requirement of prostanoid but not of superoxide production by rat Kupffer cells

Contact Info

Product

Resources

About

Pathways of Ca2+ influx at the plasma membrane: Voltage-, receptor-, and second messenger-operated channels

Cited by 221 publications

References 71 publications

Structural and functional aspects of calcium homeostasis in eukaryotic cells

Structural and functional aspects of calcium homeostasis in eukaryotic cells

Elevation of cytosolic calcium by cholinoceptor agonists in SH‐SY5Y human neuroblastoma cells: estimation of the contribution of voltage‐dependent currents

Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells

Contact Info

Product

Resources

About

Ca²⁺ requirement of prostanoid but not of superoxide production by rat Kupffer cells