Pathway-level multi-omics analysis of the molecular mechanisms underlying the toxicity of long-term tacrolimus exposure

Yen, Nguyen Thi Hai; Phat, Nguyen Ky; Oh, Jung‐Hwa; Park, Se-Myo; Moon, Kyoung-Sik; Thu, Vo Thuy Anh; Cho, Yong‐Soon; Shin, Jae‐Gook; Long, Nguyen Phuoc; Kim, Dong-Hyun

doi:10.1016/j.taap.2023.116597

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…2F and 4E ). MAP kinase and NF-κB activity are involved in corticosteroid signaling pathways in transplant immunosuppression ( 81 ) and immune suppression–induced nephrotoxicity ( 82 , 83 ), giving further credence to investigation of the scaffold implant as a means to monitor common immunosuppression regimes consisting of calcineurin inhibitors and corticosteroids. Secreted fibrinogen-like protein 2 (FGL2) by CD4 T cells potentially mediates acute graft rejection and is induced by tumor necrosis factor–α or interferon-γ stimulation through MAP kinase signaling ( 84 ).…”

Section: Discussionmentioning

confidence: 99%

Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts

Urie,

Morris,

Farris

et al. 2024

Sci. Adv.

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Invasive graft biopsies assess the efficacy of immunosuppression through lagging indicators of transplant rejection. We report on a microporous scaffold implant as a minimally invasive immunological niche to assay rejection before graft injury. Adoptive transfer of T cells into Rag2 −/− mice with mismatched allografts induced acute cellular allograft rejection (ACAR), with subsequent validation in wild-type animals. Following murine heart or skin transplantation, scaffold implants accumulate predominantly innate immune cells. The scaffold enables frequent biopsy, and gene expression analyses identified biomarkers of ACAR before clinical signs of graft injury. This gene signature distinguishes ACAR and immunodeficient respiratory infection before injury onset, indicating the specificity of the biomarkers to differentiate ACAR from other inflammatory insult. Overall, this implantable scaffold enables remote evaluation of the early risk of rejection, which could potentially be used to reduce the frequency of routine graft biopsy, reduce toxicities by personalizing immunosuppression, and prolong transplant life.

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Section: Discussionmentioning

confidence: 99%

Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts

Urie,

Morris,

Farris

et al. 2024

Sci. Adv.

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“…Inductively coupled plasma-optical emission spectrometry (ICP-OES), which is characterized by low detection limits and high precision to simultaneously determine multiple elements, has been widely used to analyze inorganic elements in food and herbal medicines (Mohamed et al, 2022;Oyebayo et al, 2022). As a rapid and precise analytical method for the qualitative and quantitative analyses of small-molecule metabolites using high-throughput chemical analysis techniques, metabolomics has been widely applied in nutritional sciences (Tebani and Bekri, 2019), toxicology (Yen et al, 2023), and plant metabolism research (Zhao et al, 2022). With the advancement of analytical techniques, metabolomics has become an essential tool for investigating plant physiology, particularly plant development (Wang C. et al, 2022) and stress resistance mechanisms (Qin et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Combined analysis of inorganic elements and flavonoid metabolites reveals the relationship between flower quality and maturity of Sophora japonica L.

Wang,

Tan,

et al. 2023

Front. Plant Sci.

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Flos Sophorae (FS), or the dried flower buds of Sophora japonica L., is widely used as a food and medicinal material in China. The quality of S. japonica flowers varies with the developmental stages (S1–S5) of the plant. However, the relationship between FS quality and maturity remains unclear. Inductively coupled plasma optical emission spectrometry (ICP-OES) and ultra-high performance liquid chromatography coupled with electrospray ionization-triple quadrupole-linear ion trap mass spectrometry (UPLC-ESI-Q TRAP-MS/MS) were used to analyze inorganic elements and flavonoid metabolites, respectively. A combined analysis of the inorganic elements and flavonoid metabolites in FS was conducted to determine the patterns of FS quality formation. Sixteen inorganic elements and 173 flavonoid metabolites that accumulated at different developmental stages were identified. Notably, 54 flavonoid metabolites associated with the amelioration of major human diseases were identified, and Ca, P, K, Fe, and Cu were postulated to influence flavonoid metabolism and synthesis. This study offers a novel perspective and foundation for the further exploration of the rules governing the quality of plant materials.

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Cyclosporine A-induced systemic metabolic perturbations in rats: A comprehensive metabolome analysis

Yen,

Tien,

Anh

et al. 2024

Toxicology Letters

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Pathway-level multi-omics analysis of the molecular mechanisms underlying the toxicity of long-term tacrolimus exposure

Cited by 3 publications

References 61 publications

Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts

Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts

Combined analysis of inorganic elements and flavonoid metabolites reveals the relationship between flower quality and maturity of Sophora japonica L.

Cyclosporine A-induced systemic metabolic perturbations in rats: A comprehensive metabolome analysis

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