Pathum Raksa Project: Addressing Disparity in Breast Cancer Care Through National Innovation in Thailand

Koonmee, Supinda; Somintara, Ongart; Intarawichian, Piyapharom; Aphivatanasiri, Chaiwat; Sangkhamanon, Sakkarn; Laohawiriyakamol, Suphawat; Panawattanakul, Rujira; Mahantassanapong, Phanchanut; Rattadilok, Chayanoot; Jeeravongpanich, Piyarat; Krongyute, Wilart; Prachumrasee, Krisada; Alaghehbandan, Reza

doi:10.2147/cmar.s335386

Cited by 1 publication

(2 citation statements)

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“…In 2015, the senior author (SK) conducted a national project (Pathum Raksa project, which means "Better Breast Cancer Treatment"), as a result of low ER+ breast cancer rates in Thailand, designing a special specimen container through a national innovation to address the issue of poor breast tissue fixation (34). In this study, we adopted the idea of the Pathum Raksa project to examine the impact of utilizing a special specimen container on the quality of CCA diagnostics in northeastern Thailand.…”

Section: Morphology Scoring Criteriamentioning

confidence: 99%

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The Impact of Pre-analytical Quality Initiatives on Cholangiocarcinoma Diagnostics in Thailand

Koonmee

Sangkhamanon²,

Intarawichian³

et al. 2022

Front. Public Health

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Cholangiocarcinoma (CCA) is the most prevalent malignancy in Thailand, with unfortunate late diagnosis and frequent metastatic disease outcomes. An accurate tissue diagnosis is the first and most important step in the treatment of CCA. Tissue quality and preservation during the pre-analytical phase play major roles in the proper histological evaluation and potential biomarker testing. This study evaluated the impact of using the “Cholangiocarcinoma Screening and Care Program (CASCAP)” container, as an innovative tool to address pre-analytical challenges faced by pathology laboratories in Thailand. This is a comparison study examining the quality of CCA specimens using the CASCAP container vs. the conventional method, using hematoxylin and eosin (H&E) and immunohistochemistry (IHC). CCA tissue quality using the CASCAP container significantly reduced artifact deposition while improving the cellular structure and nuclear and cytoplasmic morphologies. The immunohistochemical expression of cytokeratin 19 (CK19), a prognostic marker in CCA, significantly improved in the CASCAP container group in comparison with the conventional method. This innovation is proven to significantly enhance the CCA tissue quality diagnostics and prognostic biomarker testing, hence improving overall cancer care, diagnosis, and treatment in Thailand.

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Section: Morphology Scoring Criteriamentioning

confidence: 99%

“…The original container design was developed in 2012 by the senior author (SK) for the Pathum Raksa project (34). In this study, we introduced some modifications to the original design to accommodate for hepatectomy specimens handling.…”

Section: Cascap Container Designmentioning

confidence: 99%