Pathophysiology, presentation, prognosis, and management of intracranial arterial dolichoectasia

Pico, Fernando; Labreuche, Julien; Amarenco, Pierre

doi:10.1016/s1474-4422(15)00089-7

Cited by 121 publications

(183 citation statements)

References 76 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…3,4 The basilar artery is affected in 80% of these cases. 3 This arteriopathy may also affect arterial beds other than the intracranial arteries, such as the thoracic aorta.…”

mentioning

confidence: 99%

“…3,4 The basilar artery is affected in 80% of these cases. 3 This arteriopathy may also affect arterial beds other than the intracranial arteries, such as the thoracic aorta. 5 CAE is a fusiform dilatation of coronary arteries and is observed in ≤5% of coronary angiographies.…”

mentioning

confidence: 99%

“…7 A relationship between IADE and a higher incidence of coronary events has been reported. 3,8 This finding raises the possibility that muscular arteries (such as coronary and basilar arteries) may simultaneously dilate and remodel in several arterial beds. 9 We performed a case-control study to investigate the coexistence of CAE and IADE in a large consecutive autopsy database.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Coronary and Basilar Artery Ectasia Are Associated

Pico

Labreuche

Hauw

et al. 2016

Stroke

Self Cite

View full text Add to dashboard Cite

Background and Purpose— Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy series. Methods— Sixteen stroke patients with IADE were identified among 381 stroke patients and were matched with 16 stroke patients without IADE. The heart and coronary arteries from all patients were examined after a prespecified protocol. Results— Coronary artery ectasia was observed in 8 of the stroke patients with IADE, and in none of the stroke patients without IADE ( P =0.008). The diameters of basilar and right coronary arteries were positively correlated (IADE patients, r =0.51; P =0.003 and coronary artery ectasia patients, P =0.006). Conclusions— This autopsy study examining the association of coronary artery ectasia and IADE in stroke patients suggests a common pathogenesis.

show abstract

“…3,4 The basilar artery is affected in 80% of these cases. 3 This arteriopathy may also affect arterial beds other than the intracranial arteries, such as the thoracic aorta.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Coronary and Basilar Artery Ectasia Are Associated

Pico

Labreuche

Hauw

et al. 2016

Stroke

Self Cite

View full text Add to dashboard Cite

show abstract

“…Vertebrobasilar dolichoectasia (VBD) was a clinical entity characterized by elongated, dilated and/or tortuous vertebral artery, and basilar artery (BA),1, 2, 3 ranging from 0.05% to 18% 4, 5, 6. VBD presentation includes symptoms by cerebral ischemia in the vertebrobasilar territory 2, 3, 4, 5, 6…”

Section: Introductionmentioning

confidence: 99%

“…VBD presentation includes symptoms by cerebral ischemia in the vertebrobasilar territory 2, 3, 4, 5, 6…”

Section: Introductionmentioning

confidence: 99%

Perfusion by delayed time to peak in vertebrobasilar dolichoectasia patients with vertigo

Peng

Zhang

et al. 2018

Ann Clin Transl Neurol

View full text Add to dashboard Cite

ObjectiveTo investigate the association between the perfusion magnetic resonance imaging (MRI) and vertebrobasilar dolichoectasia (VBD) in vertigo patients and at least one vascular risk factor.MethodsWe studied 289 patients with vertigo (spinning, swaying, nausea, vomiting, and unsteady gait) who performed multimode MRI. Maximum diameter and tortuous parameters of the basilar artery and vertebral arteries were calculated using magnetic resonance angiography. Relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), mean transit time (MTT), and time to peak (TTP) maps were evaluated by dynamic susceptibility contrast‐enhanced perfusion imaging. Association of perfusion MRI and VBD was evaluated by nonparametric tests and receiver‐operating characteristic curve was constructed to predict posterior ischemic stroke in VBD patients.ResultsThe prevalence of VBD was 26.6% (n = 77/289) in our study. Male gender was the risk factor of VBD by multivariate analysis. BA diameter was significant statistics between ischemic stroke and nonischemic stroke patients. TTP in bilateral lower cerebellum, superior cerebellum, bilateral pons, and occipital and temporal lobes region of interests was significantly delayed in VBD versus non‐VBD patients, while rCBF, rCBV, and MTT parameters were not significant differences. TTP in the right temporal lobe delayed by 21.96 ms was the best predictive value and the mean TTP predictive threshold value in all ROIs was 22.67 ± 1.48 ms.Interpretation VBD leads to the hypoperfusion of posterior circulation territory characterized by delayed TTP. Delayed TTP in cerebellum, pons, and occipital and temporal lobes fed by vertebrobasilar arteries predicted the occurrence of posterior ischemic stroke in VBD patients.

show abstract

TGF‐β/Smads signaling pathway, Hippo‐YAP/TAZ signaling pathway, and VEGF: Their mechanisms and roles in vascular remodeling related diseases

Liu,

Sun,

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

Vascular remodeling is a basic pathological process in various diseases characterized by abnormal changes in the morphology, structure, and function of vascular cells, such as migration, proliferation, hypertrophy, and apoptosis. Various growth factors and pathways are involved in the process of vascular remodeling. The transforming growth factor‐β (TGF‐β) signaling pathway, which is mainly mediated by TGF‐β1, is an important factor in vascular wall enhancement during vascular development and regulates the vascular response to injury by promoting the accumulation of intimal tissue. Vascular endothelial growth factor (VEGF) has an important effect on initiating the formation of blood vessels. The Hippo‐YAP/TAZ signaling pathway also plays an important role in angiogenesis. In addition, studies have shown that there is a certain interaction between the TGF‐β/Smads signaling pathway, Hippo‐YAP/TAZ signaling pathway, and VEGF. Many studies have shown that in the development of atherosclerosis, hypertension, aneurysm, vertebrobasilar dolichoectasia, pulmonary hypertension, restenosis after percutaneous transluminal angioplasty, and other diseases, various inflammatory reactions lead to changes in vascular structure and vascular microenvironment, which leads to vascular remodeling. The occurrence of vascular remodeling changes the morphology of blood vessels and thus changes the hemodynamics, which is the cause of further development of the disease process. Vascular remodeling can cause vascular smooth muscle cell dysfunction and vascular homeostasis regulation. This review aims to explore the mechanisms of the TGF‐β/Smads signaling pathway, Hippo‐YAP/TAZ signaling pathway, and vascular endothelial growth factor in vascular remodeling and related diseases. This paper is expected to provide new ideas for research on the occurrence and development of related diseases and provide a new direction for research on the treatment of related diseases.

show abstract

Pathophysiology, presentation, prognosis, and management of intracranial arterial dolichoectasia

Cited by 121 publications

References 76 publications

Coronary and Basilar Artery Ectasia Are Associated

Coronary and Basilar Artery Ectasia Are Associated

Perfusion by delayed time to peak in vertebrobasilar dolichoectasia patients with vertigo

TGF‐β/Smads signaling pathway, Hippo‐YAP/TAZ signaling pathway, and VEGF: Their mechanisms and roles in vascular remodeling related diseases

Contact Info

Product

Resources

About