Pathophysiology of Wound Healing

Mills, Stuart J.; Hofma, Ben R.; Cowin, Allison J.

doi:10.1007/978-3-030-43683-4_25

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…The intricate process of wound healing involves a meticulous sequence of steps encompassing three fundamental phases: inflammation, proliferation, and remodeling [1,2]. During the inflammatory phase, neutrophils, monocytes, and macrophages are activated to eliminate cellular debris and counteract microbial intrusion, thereby averting infections [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Tissue Healing Factors in Wound Repair Involving Absorbable Meshes: A Narrative Review

Vasalou,

Kotidis,

Tatsis

et al. 2023

JCM

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Wound healing is a complex and meticulously orchestrated process involving multiple phases and cellular interactions. This narrative review explores the intricate mechanisms behind wound healing, emphasizing the significance of cellular processes and molecular factors. The phases of wound healing are discussed, focusing on the roles of immune cells, growth factors, and extracellular matrix components. Cellular shape alterations driven by cytoskeletal modulation and the influence of the ‘Formin’ protein family are highlighted for their impact on wound healing processes. This review delves into the use of absorbable meshes in wound repair, discussing their categories and applications in different surgical scenarios. Interleukins (IL-2 and IL-6), CD31, CD34, platelet rich plasma (PRP), and adipose tissue-derived mesenchymal stem cells (ADSCs) are discussed in their respective roles in wound healing. The interactions between these factors and their potential synergies with absorbable meshes are explored, shedding light on how these combinations might enhance the healing process. Recent advances and challenges in the field are also presented, including insights into mesh integration, biocompatibility, infection prevention, and postoperative complications. This review underscores the importance of patient-specific factors and surgical techniques in optimizing mesh placement and healing outcomes. As wound healing remains a dynamic field, this narrative review provides a comprehensive overview of the current understanding and potential avenues for future research and clinical applications.

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Section: Introductionmentioning

confidence: 99%

The Effects of Tissue Healing Factors in Wound Repair Involving Absorbable Meshes: A Narrative Review

Vasalou,

Kotidis,

Tatsis

et al. 2023

JCM

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show abstract

“…Wound healing is a finely tuned, multistep process that includes three main stages: inflammation, proliferation, and maturation [ 1 ]. This process comprises the spatial and temporal orchestration of different cell types that interplay with cytokines, chemokines secreted to the extracellular space by other cells [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Reforming the Barrier: The Role of Formins in Wound Repair

Ahangar

Cowin

2022

Cells

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The restoration of an intact epidermal barrier after wound injury is the culmination of a highly complex and exquisitely regulated physiological process involving multiple cells and tissues, overlapping dynamic events and protein synthesis and regulation. Central to this process is the cytoskeleton, a system of intracellular proteins that are instrumental in regulating important processes involved in wound repair including chemotaxis, cytokinesis, proliferation, migration, and phagocytosis. One highly conserved family of cytoskeletal proteins that are emerging as major regulators of actin and microtubule nucleation, polymerization, and stabilization are the formins. The formin family includes 15 different proteins categorized into seven subfamilies based on three formin homology domains (FH1, FH2, and FH3). The formins themselves are regulated in different ways including autoinhibition, activation, and localization by a range of proteins, including Rho GTPases. Herein, we describe the roles and effects of the formin family of cytoskeletal proteins on the fundamental process of wound healing and highlight recent advances relating to their important functions, mechanisms, and regulation at the molecular and cellular levels.

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