Pathophysiology of Traumatic Brain Injury

Dixon, Kirsty J.

doi:10.1016/j.pmr.2016.12.001

Cited by 187 publications

(126 citation statements)

References 79 publications

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“…For iNOS, which is an inflammatory product similar to eNOS, significant differences were observed between trauma group (131 ± 18) and the OC-treated groups (p<0.001) and also between the trauma group and the group treated with 30 mg continued apoptosis (6). To date, many agents have been used to prevent secondary injury after TBI.…”

Section: Histopathological Findingsmentioning

confidence: 99%

Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

Mete¹,

Aydemir²,

Ünsal³

et al. 2017

Turkish Neurosurgery

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Section: Histopathological Findingsmentioning

confidence: 99%

Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

Mete¹,

Aydemir²,

Ünsal³

et al. 2017

Turkish Neurosurgery

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“…More than half of the severe TBI survivors are severely disabled within one year after injury, and some patients have devastating neurological disorders, including cognitive or memory impairment, and motor, sensory or emotional function obstacles [2]. In addition, for some patients with mild repetitive TBI, such as athletes in contact sports may develop chronic traumatic encephalopathy in later life [3]. The pathophysiological mechanism of TBI has two aspects, the primary injury caused by direct mechanical force and the secondary injury of neurons.…”

Section: Introductionmentioning

confidence: 99%

“…The mechanical force of the impact directly impairs the axon and a part of a neuron. The mechanism involved in secondary injury is more complicated [3][4][5]. It includes delayed cell death (such as the newly discovered ferroptosis [6]), brain edema, metabolic defects [7], and blood-brain barrier damage caused by biochemical and physiological changes after trauma [8].…”

Section: Introductionmentioning

confidence: 99%

Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury

Zhang

et al. 2020

Mol Brain

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Background: N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA. It has been reported that there is a stimulus-dependent regulation of m6A in the mammalian central nervous system in response to sensory experience, learning, and injury. The mRNA m6A methylation pattern in rat cortex after traumatic brain injury (TBI) has not been investigated. Results: In this study, we conducted a genome-wide profiling of mRNA m6A methylation in rat cortex via methylated RNA immunoprecipitation sequencing (MeRIP-Seq). After TBI, the expressions of METTL14 and FTO were significantly down-regulated in rat cerebral cortex. Using MeRIP-Seq, we identified a total of 2165 significantly changed peaks, of which 1062 were significantly up-regulated and 1103 peaks were significantly down-regulated. These m6A peaks were located across 1850 genes. The analysis of both m6A peaks and mRNA expression revealed that there were 175 mRNA significantly altered methylation and expression levels after TBI. Moreover, it was found that functional FTO is necessary to repair neurological damage caused by TBI but has no effect on the spatial learning and memory abilities of TBI rats by using FTO inhibitor FB23-2.Conclusion: This study explored the m6A methylation pattern of mRNA after TBI in rat cortex and identified FTO as possible intervention targets in the epigenetic modification of TBI.

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“…Penetration to the brain can tear axons and damage neuron conduction, and vascular damage could lead to blood and leukocyte migration into the normally immune-privileged brain [11]. Primary brain injuries include contusions, intracranial hematomas, diffuse axonal injuries, direct cellular damage, loss of electrochemical function, and blood-brain-barrier (BBB) dysfunction.…”

Section: Primary Brain Injuriesmentioning

confidence: 99%

Complementary Traditional Chinese Medicine Therapy for Traumatic Brain Injury

Chen¹,

Hung²,

Hu³

2018

Traumatic Brain Injury - Pathobiology, Advanced Diagnostics and Acute Management

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The number of cases of traumatic brain injury (TBI) is increasing daily, predominantly because of the increasing rate of motor vehicle accidents. TBI has become one of the major causes of mortality and morbidity worldwide among individuals of all ages. TBIinducing accidents usually occur very suddenly, leading to a heavy burden for both families and society at large. Beside conventional treatments such as surgery, medication, and rehabilitation, traditional Chinese medicine (TCM) is a promising complementary therapy that is practiced worldwide. This chapter will investigate the advances in TCM therapy for TBI.

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Pathophysiology of Traumatic Brain Injury

Cited by 187 publications

References 79 publications

Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury

Complementary Traditional Chinese Medicine Therapy for Traumatic Brain Injury

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