Pathophysiology of tinnitus

Møller, Aage R.

doi:10.1016/s0030-6665(02)00170-6

Cited by 333 publications

(190 citation statements)

References 72 publications

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“…Most publications favour a steep audiogram in patients with tinnitus (14.15). Our results are consistent with the assertions of Moller, Demeeseter and Konig (24,14,15). The difference in the hearing threshold, measured between the adjacent frequencies progressively increases with a higher frequency.…”

Section: Discussionsupporting

confidence: 93%

Is There a Relationship Between Audiogram Shape and the Intensity and Duration of Tinnitus?

Trifunovic¹,

Zivic

Draskovic

et al. 2018

Serbian Journal of Experimental and Clinical Research

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Section: Discussionsupporting

confidence: 93%

Is There a Relationship Between Audiogram Shape and the Intensity and Duration of Tinnitus?

Trifunovic¹,

Zivic

Draskovic

et al. 2018

Serbian Journal of Experimental and Clinical Research

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“…Approximations of prevalence of tinnitus vary, but estimates of the American Tinnitus Association (ATA) report that approximately 40 to 50 million individuals in the United States experience tinnitus 4 . Perception of tinnitus has been associated with abnormal synchronization of auditory nerve activity 5 , imbalanced activity of type I and type II afferent fibres in the auditory nerve 6 , discordant damage to outer hair cells (OHC) and inner hair cells (IHC) systems 3,7 or central abnormalities 7,8 . Individuals with subjective tinnitus have no noticeable signs of disease, and the disease has few detectable physical correlates.…”

Section: Introductionmentioning

confidence: 99%

Auditory System Synchronization and Cochlear Function in Patients with Normal Hearing With Tinnitus: Comparison of Multiple Feature with Longer Duration and Single Feature with Shorter Duration Tinnitus

Makar¹,

Mukundan²,

Gore³

2017

The International Tinnitus Journal

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Objective: To observe cochlear and brainstem function in normal hearing ears with tinnitus using DPOAE and ABR audiometry. Design: Case-control study. Sample size: Included 60 normal hearing male patients with age less than 45 years; control group consisted of 30 patients without tinnitus and the study group consisted of those with unilateral tinnitus of at least 6 month duration. Pure tone audiometry, tinnitus matching (pitch & loudness), DPOAE (SNR & Amplitude) and ABR results of absolute latency of wave I, III and V, with IPL difference of I-III, III-V & I-V, and ILD-V were investigated. Results: SNR and amplitude value of DPOAE were significantly different between tinnitus ears and without tinnitus ears. Abnormal prolonged absolute latencies of peak I, III, V suggesting presence of hearing loss above 8 kHz and significant difference of only IPL III-V in the tinnitus ear suggesting of upper brain steam lesion in tinnitus patients were found. The IPL of III-V and ILD-V findings were significantly different in longer duration with multiple features (more than one type of pitch) than shorter duration with single feature tinnitus. Thus whole brainstem function has significant relationship with the presence of tinnitus, longer duration with multiple nature of tinnitus perception. Conclusion: Abnormal OAE and ABR results were present in patients with tinnitus. It was more prominent in patients with longer duration with multiple features of tinnitus perception.

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“…In most cases the origin of tinnitus is unknown but a close association between tinnitus and hearing dysfunction is well documented. Six main pathways were recognized: (1) discordant damage of outer (OHC) and inner (IHC) hair cells systems [1,[10][11][12]; (2) crosstalk between the VIII nerve fibres [13][14][15]; (3) ionic imbalance in the cochlea [11,16,17]; (4) dysfunction of cochlear neurotransmitter systems [14,16,17]; (5) heterogeneous activation of the efferent system [10,13,17]; (6) heterogenous activation of Type I and II cochlear afferents [1,10,13,17].…”

Section: Introductionmentioning

confidence: 99%

Clinical observations and risk factors for tinnitus in a Sicilian cohort

Martines

Sireci

Cannizzaro

et al. 2014

Eur Arch Otorhinolaryngol

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The aims of this study were to determine the distribution of risk factors associated with tinnitus analysing their role in the development of tinnitus and the effects of their interaction; to evidence the importance of a suitable and adequate clinical and audiologic assessment to avoid those modifiable risk factors responsible for cochlear dysfunction and tinnitus onset. 46 subjects with tinnitus and 74 controls were studied according to: age, sex, Body Mass Index (BMI), neck circumference, tobacco smoking, feeling fatigue or headache, self reporting snoring, hypertension, diabetes, coronary heart disease, and/or hyperlipidemia, and laboratory finding as lipid profile and levels of reactive oxygen metabolites (d-ROM). Audiological assessment was performed by multi-frequency audiometry (PTA 0.5-16 kHz ) and transient-evoked otoacoustic emissions (TEOAE diagnostic). Univariate analysis was performed to examine the association between determinants and occurrence of tinnitus; Mantel-Haenszel test (G.or) was used to investigate the joint effect of determinants on tinnitus. Tinnitus was more frequent among males with age [50 years; BMI [30 kg/m 2 , neck circumference [40 cm, headache, hypertension, hypercholesterolemia resulted significant risk factors for tinnitus (P \ 0.0001). Tinnitus group had more comorbidity (P \ 0.0001) and worse audiometric thresholds (60.87 Vs 21.62 % hearing loss; P \ 0.0001) with respect to control group. The interaction between hypertension-BMI C 30 kg/m 2 (G.or = 8.45) and smoking-hypercholesterolemia (G.or = 5.08) increases the risk of tinnitus (P \ 0.0001). Our results underline that several factors either individually or jointly contribute to tinnitus onset; a comprehensive knowledge about tinnitus risk factors and associated clinical conditions could contribute to minimizing this disorder.

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Pathophysiology of tinnitus

Cited by 333 publications

References 72 publications

Is There a Relationship Between Audiogram Shape and the Intensity and Duration of Tinnitus?

Is There a Relationship Between Audiogram Shape and the Intensity and Duration of Tinnitus?

Auditory System Synchronization and Cochlear Function in Patients with Normal Hearing With Tinnitus: Comparison of Multiple Feature with Longer Duration and Single Feature with Shorter Duration Tinnitus

Clinical observations and risk factors for tinnitus in a Sicilian cohort

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