Pathophysiology of the opening of the blood-brain and blood-cerebrospinal fluid barriers in acute hypertension

Ziylan, Y. Ziya

doi:10.1016/0014-4886(84)90002-5

Cited by 12 publications

(1 citation statement)

References 32 publications

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“…Previous studies on the water intoxication model have not demonstrated increased permeability of the blood-brain barrier (BBB) to trypan blue (Wasterlain and Posner, 1968) or Na' (Melton et al, 1987). The integrity of the BBB was not measured in the present series of experiments, and although it has been observed that the BBB and the blood-CSF barrier may open in parallel when blood pressure is raised rapidly (Ziylan, 1984), there is no correlation between brain and CSF albumin after lesioning of the barriers with protamine sulfate (Westergren and Johansson, 1990). Regardless of whether plasma hypoosmolality opened the BBB or not, it is likely that the dialysis probe itself caused some barrier damage.…”

Section: Discussioncontrasting

confidence: 63%

Elevation of Taurine in Hippocampal Extracellular Fluid and Cerebrospinal Fluid of Acutely Hypoosmotic Rats: Contribution by Influx from Blood?

Lehmann¹,

Carlström²,

Nagelhus³

et al. 1991

Journal of Neurochemistry

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Previous work has demonstrated that there is a selective increase in extracellular taurine in the brain during acute water intoxication. One aim of the present study was to investigate whether plasma taurine contributes to this increase. To this end, the concentrations of taurine, other amino acids, and ethanolamine (EA) were measured in plasma and CSF of urethane-anesthetized rats injected with 150 ml/kg body weight of distilled water. Blood pressure, blood gases, and pH, as well as plasma and CSF osmolality, were also measured. The CSF level of albumin was quantitated to study the function of the blood-CSF barrier. In separate experiments, hippocampal microdialysis was performed to determine the effects of acute plasma hypoosmolality on extracellular amino acids. Finally, the effect of water injection on hippocampal specific gravity and tissue amino acids was assessed. Blood gases and pH were essentially unchanged after water administration. Mean arterial blood pressure increased to peak levels approximately 50 mm Hg above control. Plasma osmolality decreased rapidly, whereas the depression of CSF osmolality was slower and less pronounced. The average volume of the hippocampus increased by 8%. Water injection was accompanied by a 25-fold elevation of taurine in plasma, whereas phosphoethanolamine (PEA) and EA increased moderately. A small fraction of the increase in plasma taurine might derive from blood cells because dilution of blood in vitro led to doubled plasma levels of the amino acid. Taurine, PEA, and EA increased consistently in CSF and hippocampal microdialysates. Plasma hypoosmolality transiently opened the blood-CSF barrier is reflected by augmented CSF concentrations of albumin.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussioncontrasting

confidence: 63%