Pathophysiology of the lesion around the esopagogastric junction. With special reference to the electromyogram, internal pressure and pH.

four categories (<1, 1-3, >3-10, and >10 mg/L) according to American Heart Association (AHA) criteria. We used linear mixed models, marginal models, and GEE, as appropriate, adjusting for, age, race, body mass index, education, and cycle of blood draw.RESULTS: There were 1,894 menstrual cycles from 638 women included in the analysis. Compared to CRP <1 mg/L, higher CRP levels were not significantly associated change in continuous menstrual cycle length. However, compared to CRP <1 mg/L, a CRP >10 mg/L was associated with over twice the odds of having long cycles. When evaluating follicular phase length, a CRP of >10 mg/L was associated both with follicular phases that were 2.4 days longer and with over 2.5 times the odds of being long. Compared to CRP <1 mg/L, CRP 1-3 mg/L was significantly associated with a decreased odds of short cycles and short follicular phase, respectively, with a modest increase in follicular length.CONCLUSIONS: Among women age 30-44 attempting to conceive naturally, high levels of CRP are associated with increased odds of a long cycle and longer follicular phase length.IMPACT STATEMENT: Our findings demonstrate a potential pathophysiologic association between chronic inflammation and menstrual cycle characteristics. Further studies are required to further elucidate the mechanism.

Section: Objective: To Present Two Cases Of Increased Ph Of the Uterine Cavity After Taking Lansoprazole An Oral Proton Pump Inhibitor (Pmentioning

confidence: 99%

A PROTON PUMP INHIBITOR ALTERS THE pH OF THE HUMAN UTERINE CAVITY

Ikeda

Endo

Henmi

et al. 2021

“…Jingwen Zhu, master degree, 1 Qing Xue, M.D., Ph.D, 2 Peili Wu, doctor degree, 1 Cheng Zeng, doctor degree 2 1 Peking university first hospital; 2 Peking University First Hospital, Beijing, China. OBJECTIVE: Endometriosis is an estrogen-dependent disease.…”

Section: Increased Sumoylation Of Tcf21 Improves Its Stability and Function In Human Endo-metriotic Stromal Cellsmentioning

confidence: 99%

“…2020, 9, 2478. Emily N. Sadecki, BA,1 Hao Huang, MD, MPH, 2 Tracey R. Thomas, MPH, CCRA, 1 Nanette F. Santoro, MD,3 Heping Zhang, PhD, 2 Kurt T. Barnhart, MD, MSCE 4 1 University of Pennsylvania, Philadelphia, PA; 2 Yale University School of Public Health, New Haven, CT; 3 University of Colorado Denver, Aurora, CO; 4 Univeristiy of Pennsylvania, Philadelphia, PA. OBJECTIVE: The goal of this study was to evaluate non-surgical predictors of endometriosis and severity, including variables from a quality-of-life questionnaire (Endometriosis Health Profile (EHP)) and the Endometriosis Patient Questionnaire -Standard (EPQ-S).…”

mentioning

confidence: 99%

Exploring Non-Surgical Predictors of Endometriosis Disease and Severity

Sadecki

Huang

Thomas

et al. 2021

that was similar to that of the normal control. Thus, intrauterine pH measurement is simple and seems to be quite useful as an auxiliary test for the intrauterine environment of chronic endometritis.IMPACT STATEMENT: Thus, intrauterine pH measurement is easy method and seems to be quite useful as an auxiliary test for evaluating the intrauterine environment of chronic endometritis and following its condition.

“…A PROTON PUMP INHIBITOR ALTERS THE PH OF THE HUMAN UTERINE CAVITY. Utako Ikeda, M.D., 1 Toshiaki Endo, M.D., 2 Hirofumi Henmi, M.D., 1 Tsuyoshi Baba, M.D. 2 1 Tonan Hospital, Sapporo, Japan; 2 Sapporo Medical University, Sapporo, Japan.…”

mentioning

confidence: 99%

Association Between Chronic Inflammation and Menstrual Cycle Length

Harris

Steiner

Jukic

2021

was performed by using chi-square analysis or Mann-Whitney U test where appropriate with significance determined by a p¼0.05.RESULTS: In AMA group (n¼326, average age: 41.8AE2.6 years, range: 38-51), ERPeak SM testing showed a NR result in 144 patients (44.2%) and a R result in 182 patients (55.8%). In the NRgroup, 66.7% (96/144) indicated a pre-receptive state and 33.3% (48/144) resulted in post-receptive state. In non-AMA group (n¼154, average age: 34.0AE2.7 years, range: 20-37), ER-Peak SM testing showed a NR result in 65 patients (42.2%) and a R result in 89 patients (57.8%). In the NR group, 52.3% (34/65) indicated a pre-receptive state and 47.7% (31/65) resulted in post-receptive state. The rate of prereceptive state in the AMA group was significantly higher than the non-AMA group (p<0.05). After pET with morphologically good quality embryos for NR patients, we found that the clinical pregnancy rate (CPR) and implantation rate (IR) were similar between NR and R patients (37.4% vs. 37.9% and 30.3% vs. 25.3%, respectively), which is consistent with previous studies of pET based on the ERA test. Among NR patients, pET for AMA group (n¼73, average age: 41.0AE1.9 years) and non-AMA group (n¼50, average age: 34.4AE3.2 years) showed similar CPR (34.2% vs. 42.0%, p¼0.38), IR (27.4% vs. 31.3%, p¼0.58), miscarriage rate (20.0% vs. 19.0%, p¼0.94) and live birth rate (75.0% vs. 82.4%, p¼0.59), respectively.CONCLUSIONS: Although maternal age did not influence the frequency of NR, a pre-receptive status detected by ERPeakSM was more frequently observed in AMA patients. pET after ERPeak SM testing may improve reproductive outcomes of AMA patients with RIF.IMPACT STATEMENT: Endometrial receptivity test may be useful especially for AMA patients. Embryos were selected for transfer by morphology alone, rather than chromosomal screening, which may have affected the clinical outcome. Further studies are required.