Pathophysiology of systemic sclerosis: State of the art in 2014

Dumoitier, N.; Lofek, Sébastien; Mouthon, Luc

doi:10.1016/j.lpm.2014.08.001

Cited by 56 publications

(39 citation statements)

References 118 publications

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“…We have already suggested that it can be explained by the diverse and sometimes overlapping mechanisms of PH in the setting of SSc. Indeed, SSc combines an extensive vasculopathy, inflammation, autoimmunity and fibrogenesis leading to widespread fibrosis and vascular manifestations [17]. As a consequence, PH can therefore be explained by a pulmonary arterial vasculopathy (group 1), lung fibrosis (group 3) or heart involvement (group 2) as well as by PVOD-like lesions (group 1′).…”

Section: Clinical Phenotypes Of Pulmonary Hypertensionmentioning

confidence: 99%

Pulmonary hypertension in systemic sclerosis: different phenotypes

et al. 2017

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Section: Clinical Phenotypes Of Pulmonary Hypertensionmentioning

confidence: 99%

Pulmonary hypertension in systemic sclerosis: different phenotypes

et al. 2017

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“…Upon the degree of skin involvement, extended and limited SSc are differentiated. The extensive skin damage, associated with a degree of visceral organs involvement and the presence of heart, lung or renal disease, can increase the 5 year mortality rate up to 40-50% [52][53][54][55][56].…”

Section: Hct For Systemic Sclerosismentioning

confidence: 99%

Hematopoietic Cell Transplantation for Autoimmune Diseases: A Review of History, Current State, and Future Issues

Resnick¹,

Metodiev²,

Lazarova³

2017

Immunotherapy - Myths, Reality, Ideas, Future

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Autoimmune diseases are characterized by recurrent attacks and remissions, but as a rule they progress and eventually cause a severe disability and death. The present chapter contains general characteristics of autoimmune disease pathogenesis, ways to cause immune tolerance by hematopoietic cell transplantation (HCT), clinical aspects of the treatment for established autoimmune diseases with a special attention to multiple sclerosis (MS) and systemic sclerosis (SSc). A profound analysis of authors' point of view and of the available literature has been performed. The promising results allows to consider HCT as a relevant treatment option for a certain autoimmune diseases.

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“…8 Although the pathophysiology of SSc is undoubtedly complex and remains incompletely understood, progresses have been made in elucidating at least some of the multiple mechanisms which are likely to contribute to the vascular and fibrotic alterations. 92 Most research on the changes in vascular and fibrotic features in SSc has focused on the MSCs with conflicting results. 93 BM-MSCs from patients with SSc are similar to those from healthy donors in terms of their phenotype and capacity to differentiate into adipogenic and osteogenic lineages, 94 showed an upregulation of pericytespecific markers and a decreased proliferation capacity.…”

Section: Focus On Adscs Application For Wound Healing In Systemic Sclmentioning

confidence: 99%

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

et al. 2015

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(2015) Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds, Organogenesis, 11:4, 183-206, DOI: 10.1080/15476278.2015 ABSTRACT. Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic nonhealing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care. Currently, no definitive treatment is available and the research on optimal wound care depends upon the efficacy and cost-benefit of emerging therapies.Here we provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and Systemic Sclerosis-associated ulcers, which are particularly challenging. Current and future treatment approaches are discussed with an emphasis on recent advances.

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Pathophysiology of systemic sclerosis: State of the art in 2014

Cited by 56 publications

References 118 publications

Pulmonary hypertension in systemic sclerosis: different phenotypes

Pulmonary hypertension in systemic sclerosis: different phenotypes

Hematopoietic Cell Transplantation for Autoimmune Diseases: A Review of History, Current State, and Future Issues

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

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