Pathophysiology of Obstructive Sleep Apnea in Aging Women

Qiu, Qingchao; Mateika, Jason H.

doi:10.1007/s40675-021-00218-x

Cited by 10 publications

(4 citation statements)

References 85 publications

(137 reference statements)

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“…Progesterone, in particular, is known to stimulate ventilation drive and expand the upper airway tract, hence, the reduction in its level in post- menopausal women may increase their apnoea risk. (14) Corresponding findings have been reported in similar studies conducted in Europe and the United States (15,16).…”

Section: Discussionsupporting

confidence: 70%

Proportion and Factors Associated Obstructive Sleep Apnoea (OSA) Risk Among Adults in Sepang: A Cross-sectional Study

Khamis,

Mawardi,

Abdul Rashid

2023

MJMHS

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Introduction: Sleep is often viewed by the general public as a “perceptual hole in time” where it is the period in which nothing productive occurs. However, sleep is an important part of health which affects mental and physical health. Sleep-disordered breathing (SDB) encompasses a range of respiratory disorders that are distinguished by intermittent pauses in breathing during the sleep cycle. This includes obstructive sleep apnoea (OSA), a global disease with a rising incidence along with its comorbidity. OSA creates an impact on the quality of life as it is associated with multiple negative implications which include neurocognitive problems and increases the risk of cardiometabolic diseases. This article illustrates the importance to determine the proportion of patients in the district of Sepang who are at high risk of obstructive sleep apnoea (OSA) and its determinants. Method: A cross-sectional study was carried out among individuals aged 18 years and above in Sepang district Malaysia. Using systematic random sampling, 521 participants were recruited. The questionnaire given gathered respondents information regarding their socio-demography, clinical profiles, and the STOP-BANG questionnaire was used to screen for OSA. Result: Almost a third of the participants (30.3%) were at risk of having OSA. It is found that the predictors for having OSA are menopausal women (AOR: 2.46; 95% CI: 1.22, 4.93; p = 0.011) and having large waist circumference measurement (AOR: 1.07; 95% CI: 1.04,1.10; p <0.001). Conclusion: The findings in this study will help healthcare workers to detect early patients at risk of OSA with the aid of STOP-BANG questionnaire.

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Section: Discussionsupporting

confidence: 70%

Proportion and Factors Associated Obstructive Sleep Apnoea (OSA) Risk Among Adults in Sepang: A Cross-sectional Study

Khamis,

Mawardi,

Abdul Rashid

2023

MJMHS

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“…In a recent review on OSA and menopause, a different mechanism was anticipated by which reductions in estrogen and/or progesterone hormones might cause instability in the ventilatory control system, leading to an overall increased risk for OSA and a degraded response to apneic events [ 15 ]. Both hysterectomy and oophorectomy are associated with a higher OSA risk [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Menopause Is Associated with Obstructive Sleep Apnea in a Population-Based Sample from Mecklenburg–Western Pomerania, Germany

Krüger

Obst

Ittermann

et al. 2023

JCM

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Objective: Menopause is associated with multiple health risks. In several studies, a higher incidence or a higher risk for obstructive sleep apnea (OSA) in post-menopausal than pre-menopausal women is reported. This study was designed to verify such a connection between menopause and OSA in a population-based sample. Methods: For a subsample (N = 1209) of the Study of Health in Pomerania (N = 4420), complete polysomnography data was available. Of these, 559 females completed a structured interview about their menstrual cycle. Splines and ordinal regression analysis were used to analyze the resulting data. Results: In the ordinal regression analysis, a significant association between the apnea–hypopnea index (AHI) and menopause indicated that post-menopausal women had a substantially higher risk of OSA. In accordance with previous studies, risk indicators such as body mass index (BMI), age, and the influence of hysterectomies or total oophorectomies were included in the model. Conclusions: Our results clearly confirmed the assumed connection between menopause and OSA. This is important because OSA is most often associated with male patients, and it warrants further research into the underlying mechanisms.

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“…Mild forms of air cessation during sleep, obstruction of the upper airway, and even muscle tone loss [ 16 ] can significantly affect quality of sleep. Since undisturbed breathing patterns and REM sleep is now better understood [ 17 , 18 ] the crucial REM phase has been linked with various brain disorders [ 19 , 20 ], as the upper airway is stiffer and less compliant during REM sleep than during NREM sleep [ 21 ]. Upper airway constriction is a multifactorial problem that can result from hypertrophic adenoids, a retrognathic mandible, atrophy of suprahyoid muscles especially lateral pterygoid and genioglossus muscle [ 22 ], obesity, as well as many other factors.…”

Section: Introductionmentioning

confidence: 99%

Change in the Constricted Airway in Patients after Clear Aligner Treatment: A Retrospective Study

Fountoulaki

Thurzo

2022

Diagnostics

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This retrospective study evaluated changes in the pharyngeal portion of the upper airway in patients with constricted and normal airways treated with clear aligners (Invisalign, Align). Additionally, we assessed the change of tongue position in the oral cavity from a lateral view. Evaluation was performed with specialized software (Invivo 6.0, Anatomage) on pretreatment and post-treatment pairs of cone beam computed tomography imaging (CBCT) data. The level of airway constriction, volume, cross-section minimal area and tongue profile were evaluated. Patients with malocclusion, with pair or initial and finishing CBCT and without significant weight change between the scans, treated with Invisalign clear aligners were distributed into two groups. Group A consisted of fifty-five patients with orthodontic malocclusion and constricted upper airway. Control group B consisted of thirty-one patients with orthodontic malocclusions without any airway constriction. In the group with airway constriction there was a statistically significant increase in volume during therapy (p < 0.001). The surface of the most constricted cross-section of the airway did not change significantly after treatment in any of the groups. The final tongue position was different from the initial position in 62.2% of all clear aligner treatments. The position of the smallest clearance of the airway in the pharynx was similar for both groups localized at the level of 2nd cervical vertebra.

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Pathophysiology of Obstructive Sleep Apnea in Aging Women

Cited by 10 publications

References 85 publications

Proportion and Factors Associated Obstructive Sleep Apnoea (OSA) Risk Among Adults in Sepang: A Cross-sectional Study

Proportion and Factors Associated Obstructive Sleep Apnoea (OSA) Risk Among Adults in Sepang: A Cross-sectional Study

Menopause Is Associated with Obstructive Sleep Apnea in a Population-Based Sample from Mecklenburg–Western Pomerania, Germany

Change in the Constricted Airway in Patients after Clear Aligner Treatment: A Retrospective Study

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