Pathophysiology of migraine

Goadsby, Peter J.

doi:10.4103/0972-2327.99993

Cited by 123 publications

(78 citation statements)

References 79 publications

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“…The trigeminal ganglion contains neurons that peripherally innervate the intracranial vasculature and dura mater. The trigeminal ganglion also centrally projects to the brainstem, in related extensions down to the spinal cord and to parts of the CNS where nociceptive information is processed to higher cortical regions (Liu et al, 2009;Goadsby, 2012). Stimulation of the trigeminal ganglion resulted in release of CGRP and elevation of CGRP in the external jugular vein (Goadsby et al, 1988;Limmroth et al, 2001).…”

Section: Introductionmentioning

confidence: 98%

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Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood–brain barrier

et al. 2015

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Section: Introductionmentioning

confidence: 98%

“…Migraine is today recognized as a neurovascular disorder which originates in the brain, involving the hypothalamus and thalamus, as well as certain brainstem regions (Goadsby, 2012). The acute migraine attack is often preceded by prodromal symptoms, which suggest the central nervous system (CNS) as a likely point of origin (Charles, 2013).…”

Section: Introductionmentioning

confidence: 99%

Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood–brain barrier

et al. 2015

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“…unilateral, throbbing, worsened by movement, moderate or severe or any one i.e. nausea/vomiting, photophobia and phonophobia are the most characteristics clinical phenotype of migraine 23 . Typically pain is unilateral and significant number of cases becomes bilateral often, late in an attack.…”

Section: Signs and Symptomsmentioning

confidence: 99%

Correlation of Stress with Migraine - A Review

2017

IJCRR

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Migraine is a widespread and debilitating neurological disorder that has been recognized since antiquity. The World Health Organization has listed migraine as a significant public health concern and major cause of years of life with disability. It is aperiodic disorder that comprises paroxysmal and blinding hemicranial pain, nausea/vomiting, photophobiaand phonophobia. Stress is often linked to the occurrence of migraine headaches. Stress may interact with migraine in several ways that predisposed to migraine attacks. Stress is considered as a most common trigger for their attacks and high level of stress are reported in migraine patients. Migraine attacks themselves can act as a stressor, thereby potentially leading to a vicious cycle of increasing migraine frequency. This review provides an overview that both stress and migraine are reciprocally related i.e. cyclically influencing each other across time.

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“…An episodic, unilateral, severe, and throbbing headache is its characteristic property [2]. The disease may be associated with autonomic symptoms, and aura, a focal neurological symptom, may occur in one-third of the patients [3]. For many years, the dura mater and its vasculature have been at the center of the hypotheses trying to explain the pathophysiology of migraine [4,5].…”

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confidence: 99%

Is Migraine Related to Medial Meningeal Artery and Spinous Foramen Caliber?

Nalbant¹

2017

Ann Clin Anal Med

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ÖzetAmaç: Migren, tüm başağrısı hastalıkları içinde doktora en fazla başvuru nedenlerinden birisidir ve günümüzde halen migren tanısı için özel bir laboratuvar testi veya radyolojik inceleme yoktur. Migren ağrısında altta yatan mekanizmanın medial meningeal arter vazodilatasyonun neden olduğuna dair geniş bir inanç vardır. Öte yandan son zamanlarda pek çok hipotez vazodilatasyonun rolünü azaltmaktadır. Atak sırasında medial meningeal arterde dilatasyon gelişiyorsa kronik dönemde içinden geçtiği forameni de genişletebilir.Çalışmamızda bu fikirden yola çıkarak migren tanısı olan hastalarda kontrol grubuna göre medial meningeal arter çapı ile spinöz foramen alanında farklılık olup olmadığının araştırılması amaçlandı. Gereç ve Yöntem: Çalışmaya migrenli 36 hasta ve kontrol grubu olarak gerilim tipi baş ağrısı olan 26 hasta alındı. Hastalara çok kesitli beyin BT (bilgisayarlı tomografi) anjiografi tetkiki yapıldı. Migrenli olgular ile kontrol grubu olgularının tümünde her iki taraf medial meningeal arter ve spinöz kanal alanı ölçüldü. Bulgular: Migren hastaları ile kontrol grubunun medial meningeal arter çapı ve spinöz kanal alanı ölçümleri arasında istatistiksel olarak anlamlı farklılık saptanmadı. Tartış-ma: Çalışmamızda migren patofizyolojisinde dura materi besleyen damarlardaki vazodilatasyonun etken olduğunu gösterecek bulgu saptanmadı. Bu sonuç migren patofizyolojisinde ve etyolojisinde farklı hipotezlerin araştırılma-sı gerektiğini göstermesi açısından önemlidir. Anahtar KelimelerMigren; Meningeal Arter; BT Anjiografi Abstract Aim: Although migraine is one of the headache disorders for which people most often consult a doctor, it still does not have a specific diagnostic laboratory or radiologic test. Vasodilation of the medial meningeal artery is widely believed to cause migraines. However, some current hypotheses decrease the role of the vasodilation. If the medial meningeal artery dilates during attacks, in the long term it can expand the foramen pass through. Based on this idea, our study investigated whether there is a significant difference between the medial meningeal artery and spinous foramen sizes of migraine patients compared with a control group. Material and Method: Thirty-six migraine patients and 26 tension-type headache (TTH) patients as the control group were involved in the study. Patients were scanned with brain CT (computed tomography) angiography. The medial meningeal artery and spinous foramen sizes of both groups were measured. Results: There was no statistically significant difference between the measurements of migraine and tension-type headache patients. Discussion: In our study we could not find any evidence to show vasodilation of the dura mater's vasculature as a factor of migraine pathophysiology. This result indicates the need to continue investigating the different hypotheses for migraine pathophysiology.

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Pathophysiology of migraine

Cited by 123 publications

References 79 publications

Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood–brain barrier

Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood–brain barrier

Correlation of Stress with Migraine - A Review

Is Migraine Related to Medial Meningeal Artery and Spinous Foramen Caliber?

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