Pathophysiology of Human Tears

Tapasztó, I.

doi:10.1097/00004397-197301310-00010

Cited by 28 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tear fluid presents an abundance of molecular targets that can provide valuable information about the well-being of a patient [1,2]. In particular, continuous monitoring of specific biomarkers can be especially effective in early detection of various cancers [3,4], early warning of stroke occurence based on lactate measurements [5], and constant monitoring of glucose levels in diabetic patients [6].…”

Section: Introductionmentioning

confidence: 99%

A synthetic eye platform for testing contact lenses with integrated electronic biosensors

Afanasiev

Yao

Marcheselli

et al. 2011

2011 11th IEEE International Conference on Nanotechnology

View full text Add to dashboard Cite

Building an interface between a nano-scale system and the larger-scale world is of utmost importance in implementing and testing the system utility. By taking advantage of the enzyme function at the nano-scale, our group is developing functional contact lenses integrating electronic biosensors that can detect and report the level of glucose on the surface of the eye. In order to verify the functionality of the contact lenses we have developed a physiologically accurate mechanical model of a human eye which allows sensor characterization under thin-film conditions, in a controlled chemical environment. The polymer eye model replicates the geometry of an eye, the blinking motion of an eyelid, as well as the tear fluid input and output microchannels. Liquid used in the experiments was prepared to closely mimic the chemical and mechanical properties of biological tear fluid.

show abstract

Section: Introductionmentioning

confidence: 99%

A synthetic eye platform for testing contact lenses with integrated electronic biosensors

Afanasiev

Yao

Marcheselli

et al. 2011

2011 11th IEEE International Conference on Nanotechnology

View full text Add to dashboard Cite

show abstract

“…Tear fluid contains many biological markers whose concentrations change in dependency of the health status of a patient, such as glucose, lactate, ascorbic acid as well as lipids, proteins or cytokines [4,5]. Glucose levels in the tear fluid are reported to increase proportional to the blood glucose level and may therefore be measured for the supervision of a diabetic patient [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Lactate levels in the body have been shown to increase significantly shortly before a stroke [8,9]. Protein and lipid concentrations in the tear fluid are known to change for certain conditions of the eye, such as bacterial or viral conjunctivitis or viral keratitis [4]. This is also the case for iritis, which is usually considered an indicator for autoimmune disorders like rheumatiod arthritis, AIDS or herpes zoster [4].…”

Section: Introductionmentioning

confidence: 99%

“…Protein and lipid concentrations in the tear fluid are known to change for certain conditions of the eye, such as bacterial or viral conjunctivitis or viral keratitis [4]. This is also the case for iritis, which is usually considered an indicator for autoimmune disorders like rheumatiod arthritis, AIDS or herpes zoster [4]. Conjunctivitis or trachoma caused by ocular Chlamydia infections are considered a major cause of blindness in the world [10,11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Contact Lenses for Remote Health Monitoring in Developing Countries

Thomas

Lähdesmäki

Lingley

et al. 2011

2011 IEEE Global Humanitarian Technology Conference

View full text Add to dashboard Cite

The opportunities afforded by using a functional contact lens for remote wireless health status monitoring are discussed and the progress to date in the development of this technology platform is presented. A functional contact lens complete with sensors and embedded circuitry can be used to monitor the composition of tear fluid and, by extension, a number of health-status related parameters in the body in a noninvasive and continuous fashion. The data collected by the disposable contact lens may be sent wirelessly to a mobile phone that, in turn, can relay the information to a medical practitioner via the cellular phone network. If successfully developed and deployed, such a system can be used for monitoring a variety of health indicators over a large geographic area and population distribution with minimal need for the physical presence of health care providers.

show abstract

“…A well balanced ocular surface milieu is important for the well being of the ocular surface. Topically applied eye drops can alter the milieu of the tear pool 1. Although manufacturers adjust the pH and osmolarity so that they are close to that of the normal conjunctival surface, the electrolyte levels are not adjusted to physiological levels.…”

mentioning

confidence: 99%