Pathophysiology of Generalized Intravascular Coagulation

Müller‐Berghaus, Gert

doi:10.1055/s-0028-1087119

Cited by 41 publications

(2 citation statements)

References 149 publications

(208 reference statements)

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“…The resultant fibrin strands are then seen in the test tube. While some fibrin monomers are complexing with degradation products to form soluble fibrin monomer complexes, other fibrin monomers polymerize primarily in the microvasculature, leading to impedance of blood flow, tissue hypoxia, and resultant ischemia and necrosis in multiple end organs [78]. In addition, polymerized fibrin deposited in the microvasculature leads to entrapped platelets and attendant thrombocytopenia, and may cause microangiopathic hemolytic anemia from fibrin-red cell contact [98].…”

Section: A Disseminated Intravascular Coagulation In Malignancymentioning

confidence: 99%

Alterations of Hemostasis Associated With Malignancy: Etiology, Pathophysiology, Diagnosis and Management

Bick¹

2008

Semin Thromb Hemost

125

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Section: A Disseminated Intravascular Coagulation In Malignancymentioning

confidence: 99%

Alterations of Hemostasis Associated With Malignancy: Etiology, Pathophysiology, Diagnosis and Management

Bick¹

2008

Semin Thromb Hemost

125

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“…There were several approaches to this idea. Among them, compensated and decompensated DIC [5], chronic DIC [6], evident and latent DIC [7], and pre-DIC. One more reason of such a high mortality from DIC is the presence of misunderstanding regarding the early diagnosis of this life-theatening clinical phenomenon, and also in the choice of treatment of these patients after making this menacing diagnosis.…”

Section: Is It Easy To Define Dic Syndrome?mentioning

confidence: 99%

Detection of disseminated intravascular coagulation with the help of the conception of constant intravascular microcoagulation

Бокарев

Попова

2010

Srp Arh Celok Lek

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The possibility of intravascular blood coagulation existence in the microvascular vessels and capillaries without the presence of a large thrombus in the arteries and veins has been known from the middle of 19th century. It is impossible to know exactly about the prevalence of this pathology, because there is a jumble in terminology that does not help statistics to be exact. One of the reasons of so high mortality from disseminated intravascular coagulation (DIC) is due to the impossibility to always make exact diagnosis, and as M. Levi thinks it is provoked in the absence of generally accepted idea of DIC syndrome. We investigated these markers and the intensity of intravascular blood coagulation in a number of patients. Our understanding of the problems of DIC was formulated on the grounds of a thirty-year study of the problem involving over 1,500 patients. Thereby, the conception of constant intravascular microcoagulation (CIMC) was developed with the following aims: to report the existing material and bring to researchers and doctors in practice information about the presence of the phenomenon of CIMC and to resolve debatable questions of definitions and practical usage of up-to-date information about DIC with the help of CIMC conception.

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Plasma level of tumor necrosis factor in disseminated intravascular coagulation

et al. 1991

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The plasma level of tumor necrosis factor (TNF) was determined in 20 normal individuals, 52 patients with disseminated intravascular coagulation (DIC), 22 pre-DIC patients, and 39 non-DIC patients. TNF was not detected in the normal subjects, and the level was very low in non-DIC patients. However, the TNF level was significantly elevated in DIC patients, and it was moderately increased in pre-DIC patients shortly before the onset of DIC. This increase in circulating TNF may be associated with DIC. TNF was higher in DIC associated with solid cancer than in DIC associated with leukemia or sepsis. The increase in plasma TNF level was mildly correlated with DIC score, and it was significantly increased in patients with poor prognosis. However, the plasma TNF level in DIC patients with organ failure was not significantly different from those without organ failure. We conclude that the increase in circulating TNF reflects the pathogenic factors in DIC rather than being a consequence of organ failure due to DIC.

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Pathophysiology of Generalized Intravascular Coagulation

Cited by 41 publications

References 149 publications

Alterations of Hemostasis Associated With Malignancy: Etiology, Pathophysiology, Diagnosis and Management

Alterations of Hemostasis Associated With Malignancy: Etiology, Pathophysiology, Diagnosis and Management

Detection of disseminated intravascular coagulation with the help of the conception of constant intravascular microcoagulation

Plasma level of tumor necrosis factor in disseminated intravascular coagulation

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