Pathophysiology of Erythropoiesis in Renal Diseases

Pavlović-Kentera, V; Clemons, Gisela K.; Djukanović, Ljubica

doi:10.1007/978-3-642-83745-6_9

Cited by 3 publications

(4 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have found that patients with ADPKD frequently have higher values of hemoglobin and erythropoietin when compared with uremic patients suffering from noncystic renal diseases (3)(4)(5)(6). This agrees with the concept that a higher EPO production is a major reason for the less severe anemia in these patients.…”

Section: Discussionsupporting

confidence: 85%

“…The relationship between hemoglobin and serum EPO concentrations for the patients with ADPKD strikingly differs from the normally found inverse relationship of anemic patients with intact renal function (6,29, and own observations). In contrast, it appears from previous studies (4,6) as if the hemoglobin concentration and EPO are positively correlated, suggesting an autonomous rather than a regulated EPO production. A genetical determination of EPO production in association with ADPKD seems not very likely, because also solitary cysts have been found to contain EPO and to be accompanied with elevated serum EPO levels (7, and own unpublished data).…”

Section: Discussionmentioning

confidence: 74%

“…Usually patients suffering from end stage renal disease develop an anemia which results predominantly from insufficiently low erythropoietin (EPO) production by the damaged kidneys (2). Interestingly, the degree of anemia is strikingly moderated if ADPKD is the reason for renal insufficiency (3)(4)(5)(6). Based on the observations that serum EPO levels in patients with ADPKD are on average twofold higher than in end-stage renal disease of other causes (4)(5)(6) and that renal cysts may contain erythropoietic activity (7,8) it is assumed that an improved 1.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, the degree of anemia is strikingly moderated if ADPKD is the reason for renal insufficiency (3)(4)(5)(6). Based on the observations that serum EPO levels in patients with ADPKD are on average twofold higher than in end-stage renal disease of other causes (4)(5)(6) and that renal cysts may contain erythropoietic activity (7,8) it is assumed that an improved 1. Abbreviations used in this paper: ADPKD, adult dominant polycystic kidney disease; EPO, erythropoietin.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Erythropoietin in polycystic kidneys.

Eckardt¹,

Möllmann²,

Neumann³

et al. 1989

J. Clin. Invest.

115

View full text Add to dashboard Cite

Erythropoietin (EPO) formation in kidneys of 18 patients with autosomal dominant polycystic kidney disease (ADPKD) was investigated. In 12 patients on hemodialysis and in 6 patients with preterminal renal failure serum, EPO was 29±7 and 16±1.5 mU/mI and hemoglobin concentrations were 11.0±0.6 and 12.7±1.2 g/dl, respectively. Cyst fluid from a total of 357 renal cysts was obtained by either in vivo aspiration or immediately after nephrectomy. The cysts contained variable concentrations of bioactive EPO from undectable values up to 3.2 U/ml. A pronounced enrichment of EPO was observed in cysts with sodium concentrations > 100 mmol/liter, suggesting an association with proximal tubular malformations. The EPO concentrations in the cysts were neither c orrelated with the protein concentration nor with the oxygen pressure of the cyst fluid. Using a cDNA probe for human EPO, mRNA for EPO was localized in stroma cells of the cyst walls by an in situ hybridization technique. Our findings suggest that single interstitial cells juxtaposed to proximal tubular cysts may produce EPO independent of the oxygen pressure inside the cysts, which ameliorates the anemia during end-stage polycystic kidney disease.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Erythropoietin in polycystic kidneys.

Eckardt¹,

Möllmann²,

Neumann³

et al. 1989

J. Clin. Invest.

115

View full text Add to dashboard Cite

show abstract

Serum Erythropoietin and Interleukin-6 Levels in Hemodialysis Patients with Hepatitis Virus Infection

Radović¹,

Jelkmann²,

Djukanović³

et al. 1999

Journal of Interferon & Cytokine Research

View full text Add to dashboard Cite

The influence of hepatitis B (HBV) and hepatitis C virus (HCV) infection on blood hemoglobin (Hb) and serum erythropoietin (Epo) and interleukin-6 (IL-6) concentrations was studied in 48 anemic patients on regular hemodialysis. They were grouped as follows: (I) 19 patients whose Hb values improved after infection (Hb > 85 g/L), (II) 10 patients with persisting anemia after infection (Hb < 75 g/L), and, without hepatitis virus markers (III) 8 patients with Hb > 85 g/L and (IV) 11 patients with Hb < 75 g/L. Serum immunoreactive Epo levels were significantly higher in group I (34.4+/-47.1 U/L) than in the other groups (II, 10.8+/-6.0; III, 7.9+/-3.2; IV, 8.4+/-4.3). Serum IL-6 was higher in group I than group III (7.7+/-7.8 pg/ml vs. 3.6+/-2.4; p = 0.05) but similar to the other groups. Hb levels in group I were maximal at the time of serum alanine aminotransferase normalization. Red cell production increases as a result of elevated circulating Epo during hepatic regeneration after HBV or HCV infection.

show abstract

Blockage of the Na-K-ATPase signaling-mediated oxidant amplification loop elongates red blood cell half-life and ameliorates uremic anemia induced by 5/6th PNx in C57BL/6 mice

Liu

Chaudhry

Bai

et al. 2022

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

We have previously demonstrated that the Na/K-ATPase signaling-mediated oxidant amplification loop contributes to experimental uremic cardiomyopathy and anemia induced by 5/6th partial nephrectomy (PNx). This process can be ameliorated by systemic administration of the peptide, pNaKtide, which was designed to block this oxidant amplification loop. The present study demonstrated that the PNx induced anemia is characterized by marked decreases in RBC survival as assessed by biotinylated RBC clearance and eryptosis as assessed by annexin V binding. No significant change in iron homeostasis was observed. Examination of plasma samples demonstrated that PNx induced significant increases in systemic oxidant stress as assessed by protein carbonylation, plasma erythropoietin (EPO) concentration, and BUN. Systemic administration of pNaKtide, but not by NaKtide (pNaKtide without TAT leader sequence) and a scramble "pNaKtide" (sc-pNaKtide), led to the normalization of hematocrit, RBC survival, plasma protein carbonylation. Administration of the three peptides has no significant effect on PNx-induced increases in plasma EPO and BUN, without notable changes in iron metabolism. These data indicate that blockage of the Na/K-ATPase signaling-mediated oxidant amplification loop ameliorates the anemia of experimental renal failure by increasing the RBC survival.

show abstract

Pathophysiology of Erythropoiesis in Renal Diseases

Cited by 3 publications

References 70 publications

Erythropoietin in polycystic kidneys.

Erythropoietin in polycystic kidneys.

Serum Erythropoietin and Interleukin-6 Levels in Hemodialysis Patients with Hepatitis Virus Infection

Blockage of the Na-K-ATPase signaling-mediated oxidant amplification loop elongates red blood cell half-life and ameliorates uremic anemia induced by 5/6th PNx in C57BL/6 mice

Contact Info

Product

Resources

About