Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals

Mobasheri, Leila; Ahadi, Mitra; Beheshti Namdar, Ali; Alavi, Mohaddeseh Sadat; Bemidinezhad, Abolfazl; Moshirian Farahi, Seyed Mostafa; Esmaeilizadeh, Mahdi; Nikpasand, Niloofar; Einafshar, Elham; Ghorbani, Ahmad

doi:10.1016/j.biopha.2023.115502

Cited by 4 publications

(1 citation statement)

References 158 publications

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“…Furthermore, HR of incident T2DM in overweight/obese patients without NAFLD and in overweight/obese patients with NAFLD was 1.32 (95% CI: 0.99–1.77) and 2.98 (1.66–5.32) compared with lean patients without NAFLD [ 58 ]. Underlying pathophysiological mechanisms include insulin resistance, hyperglycemia, hyperinsulinemia, oxidative stress, inflammation, endothelial dysfunction, dysregulation of adipose tissue function and lipid dysmetabolism (lipotoxicity) [ 59 , 60 ].…”

Section: T2dm and Liver Dysfunctionmentioning

confidence: 99%

The Cardiac-Kidney-Liver (CKL) syndrome: the “real entity” of type 2 diabetes mellitus

Katsiki,

Kolovou,

Melidonis

et al. 2024

Arch Med Sci

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Section: T2dm and Liver Dysfunctionmentioning

confidence: 99%

The Cardiac-Kidney-Liver (CKL) syndrome: the “real entity” of type 2 diabetes mellitus

Katsiki,

Kolovou,

Melidonis

et al. 2024

Arch Med Sci

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Nitric oxide donor S‐Nitroso‐N‐acetyl penicillamine for hepatic stellate cells to restore quiescence

Du,

He,

Jia

et al. 2024

Pediatric Discovery

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Liver fibrosis is a hepatic scar repair response associated with a wide range of liver injuries, which is mediated by an imbalance between extracellular matrix (ECM) synthesis and degradation, leading to massive ECM deposition and disruption of normal liver architecture. Hepatic stellate cells (HSCs) are the main source of ECM during liver fibrosis and are the first identified cell subpopulation associated with liver fibrosis formation. Various current studies on the mechanism and treatment of liver fibrosis require resting‐state HSCs as study subjects. However, spontaneous activation of primary HSCs occurs after 2–3 days of culture after isolation, and it is common that HSCs cell lines gradually differentiate into fibroblasts with culture time. This study provides an induction medium for quiescent HSCs‐containing all‐trans retinoic acid, sodium oleate, and S‐nitroso‐N‐acetyl penicillamine (SNAP)‐and an induction method. The induction method not only maintains the HSCs cell line in a quiescent state but also restores the activated HSCs to a quiescent state. The method has a good induction effect, short induction time, and convenient operation, which is worth being popularized and used in a wide range of laboratories.

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Herbal and Non-Herbal Dietary Supplements for Psychiatric Indications: Considerations in Liver Transplantation

Patel,

Tareen,

Patel

et al. 2024

Curr Psychiatry Rep

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Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals

Cited by 4 publications

References 158 publications

The Cardiac-Kidney-Liver (CKL) syndrome: the “real entity” of type 2 diabetes mellitus

The Cardiac-Kidney-Liver (CKL) syndrome: the “real entity” of type 2 diabetes mellitus

Nitric oxide donor S‐Nitroso‐N‐acetyl penicillamine for hepatic stellate cells to restore quiescence

Herbal and Non-Herbal Dietary Supplements for Psychiatric Indications: Considerations in Liver Transplantation

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