Pathophysiology of contrast-induced nephropathy

Wong, Philip Ching Yat; Li, Zicheng; Guo, Jun; Zhang, Aidong

doi:10.1016/j.ijcard.2011.06.115

Cited by 163 publications

(168 citation statements)

References 72 publications

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“…Previous studies have demonstrated that the pathogenesis of CIN is associated with ischemia, hypoxia, oxidative stress and direct toxicity (23). A previous study by our group indicated that NOX and oxidative stress serve an important role in CIN (24).…”

Section: Discussionmentioning

confidence: 73%

Atorvastatin alleviates iodinated contrast media-induced cytotoxicity in human proximal renal tubular epithelial cells

Liu

Lei

Duan

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Contrast media (CM)-induced nephropathy (CIN) is a serious complication of intravascularly applied radiocontrast media. At present, no drugs have been approved for the prevention of CIN. The present study aimed to explore the effects and potential mechanisms of atorvastatin on iodinated CM-induced cytotoxicity in the human proximal renal tubular epithelial cells. The cytotoxic effect of iohexol (50, 100 and 200 mg I/ ml) and the protective effect of atorvastatin pretreatment (1, 20 and 40 µM) were assessed. The cytotoxicity of iohexol was evaluated via the MTT cell viability and lactate dehydrogenase assays. The amount of apoptotic cells was determined by flow cytometry. Morphological changes in HK-2 cells were observed via transmission electron microscopy. The mRNA expression of NOX4 and p22phox was measured through reverse transcription-quantitative polymerase chain reaction analysis. The cytotoxicity was induced by iohexol in HK-2 cells. Atorvastatin was identified to significantly alleviate the suppression of cell viability induced by iohexol. Notably, 40 µM atorvastatin also significantly reduced the mRNA expression of intracellular NOX4 and p22phox, and the percentage of apoptotic cells. Furthermore, morphological changes characteristic of injured cells were alleviated by atorvastatin pretreatment. These results suggest that atorvastatin exhibits a protective effect on HK-2 cells against iohexol-induced cytotoxicity through the downregulation of NOX4 and p22phox. Thus, atorvastatin is a potential therapeutic agent for the prevention of CIN and required further study.

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Section: Discussionmentioning

confidence: 73%

Atorvastatin alleviates iodinated contrast media-induced cytotoxicity in human proximal renal tubular epithelial cells

Liu

Lei

Duan

et al. 2017

Experimental and Therapeutic Medicine

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“…Besides that, this study confirmed the positive effect of B. vulgaris on contrast media-induced kidney tissue such that in group treated with B. vulgaris extract to prevent kidney injury, the rate of tissue damage deceased significantly. Contrast medium-induced nephropathy involves multiple factors resulting in hypoxia of the medulla which in turn cause acute tubular necrosis (20). As it was said the pathophysiology of contrast media in induction of AKI is based on medullary ischemia induced by various factors including tubular cell toxicity and formation of free radicals (20).…”

Section: Discussionmentioning

confidence: 99%

“…Contrast medium-induced nephropathy involves multiple factors resulting in hypoxia of the medulla which in turn cause acute tubular necrosis (20). As it was said the pathophysiology of contrast media in induction of AKI is based on medullary ischemia induced by various factors including tubular cell toxicity and formation of free radicals (20). Hence, controlling these mechanisms seems to be effective to control of CI-AKI.…”

Section: Discussionmentioning

confidence: 99%

The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury

Asgharian¹,

Lorigooini²,

Rafieian³

et al. 2017

J Nephropathol

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“…Medication with statin was introduced before surgery expecting plaque stabilization, and administration of atrial natriuretic peptide and hydration was started one day before surgery for prevention of contrastinduced nephropathy. [3][4][5][6][7] For minimal manipulation of the aorta, treatment with a single stent graft was considered. The treatment length was 134.5 mm.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Successful Endovascular Treatment of Saccular Thoracic Aneurysm with “Shaggy Aorta”

Hori

Yasuda

Noguchi

et al. 2012

ATCS

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A 68 year old man was admitted to our hospital with dysphagia and back pain. Contrasted computed tomography showed "Shaggy aorta" forming a saccular descending aortic aneurysm with edematous esophagus. Low density area in the intramuscular layer of the esophagus suggested the possibility of connection between the esophagus and the aneurysm. The patient underwent endovascular treatment of the aneurysm. The postoperative course was uneventful, and the patient was discharged from the hospital with improvement in his symptoms. Although there are reports suggesting endovascular treatment as a contraindication for shaggy aorta due to risk of embolization, it may be considered as an option for a patient who is in need of surgical treatment.

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Pathophysiology of contrast-induced nephropathy

Cited by 163 publications

References 72 publications

Atorvastatin alleviates iodinated contrast media-induced cytotoxicity in human proximal renal tubular epithelial cells

Atorvastatin alleviates iodinated contrast media-induced cytotoxicity in human proximal renal tubular epithelial cells

The preventive effect of Berberis vulgaris extract on contrastinduced acute kidney injury

Case Report: Successful Endovascular Treatment of Saccular Thoracic Aneurysm with “Shaggy Aorta”

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