Pathophysiology of Allergic Rhinitis

Ceylan, Mehmet Emrah; Cingi, Cemal; Özdemir, Cevdet; Küçüksezer, Umut Can; Akdiş, Cezmi A.

doi:10.1007/978-3-030-21217-9_32

Cited by 2 publications

(1 citation statement)

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“…Allergic Rhinitis or hay fever is a response to specific allergens and is attributed to a set of symptoms caused by nasal congestion such as sneezing, a runny nose, a stuffy nose, an itchy nose, coughing, a sore or scratchy throat, itchy eyes, dark circles under the eyes, and hives. These symptoms appear when allergens such as dust mites or pollens enter the nose via breathing (1) due to increased allergic reactions (2). According to global statistics, above 600 million persons suffer from allergic rhinitis worldwide (3).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Serum Level of Interleukin-33 and Allergic Rhinitis and Its Severity in Children

2021

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Background: T helper type 2 (Th2) cells are critical cellular elements in allergic rhinitis. Interleukin-33 (IL-33) produces Th2-related cytokines and binds to the ST2 receptors. This is expressed strongly in mastocytes and discerningly in Th2 cells. Through Th2 cells, IL-33 may also have partly involved in immune responses. Objectives: This study aimed to measure the IL-33 serum levels in children suffering from allergic rhinitis and investigate its relationship with the disease. Methods: This case-control study was conducted on a population with the age range of 7-18 years, who referred to the Pediatric Clinic of the Shahid Beheshti Hospital in Kashan, Iran, in 2017. The study sample encompassed 57 patients with allergic rhinitis (case group) and 57 subjects with no allergic rhinitis (control group). The ELISA assay was used to measure the serum level of IL-33 in the case and control groups. Allergic rhinitis was diagnosed by a pediatric immunologist considering the patient’s history and the guidelines set out by the Allergic Rhinitis and its Impact on Asthma (ARIA). All study data were analyzed with SPSS software version 22. Results: There were significant differences between the two groups in terms of age (P = 0.001), gender (P = 0.0144), family history of atopy (P < 0.001), symptoms duration (P < 0.001), and comorbidities (e.g., atopic dermatitis and asthma) (P < 0.001). Furthermore, compared to the control group, the case group exhibited significantly higher IL-33 serum levels (P < 0.001). Conclusions: The high serum levels of IL-33 exhibited in patients with allergic rhinitis indicate its involvement in the pathogenesis of the concerned disease.

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Section: Introductionmentioning

confidence: 99%