Pathophysiology of Adult Obstructive Sleep Apnea

Eckert, Danny J.; Malhotra, Atul

doi:10.1513/pats.200707-114mg

Cited by 508 publications

(374 citation statements)

References 148 publications

(149 reference statements)

Supporting

Mentioning

321

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, a clear increase in the PSDn of SAHS-positive subjects can be observed in the range 0.015-0.060 Hz, covering part of VLF and LF bands (see Figure 3). It has been established that the typical duration of apnoeic events ranges from 20 to 40 s [45], which in the frequency domain would mainly affect the 0.025-0.050 Hz band. Latest studies confirmed this as the band with the highest statistically significant differences between SAHSpositive and SAHS-negative subjects in the airflow signal [46,47].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Time and Frequency Domain Entropies to Detect Sleep Apnoea in Heart Rate Variability Recordings from Men and Women

Gutiérrez‐Tobal

Álvarez

Gómez‐Pilar

et al. 2015

Entropy

View full text Add to dashboard Cite

Heart rate variability (HRV) provides useful information about heart dynamics both under healthy and pathological conditions. Entropy measures have shown their utility to characterize these dynamics. In this paper, we assess the ability of spectral entropy (SE) and multiscale entropy (MsE) to characterize the sleep apnoea-hypopnea syndrome (SAHS) in HRV recordings from 188 subjects. Additionally, we evaluate eventual differences in these analyses depending on the gender. We found that the SE computed from the very low frequency band and the low frequency band showed ability to characterize SAHS regardless the gender; and that MsE features may be able to distinguish gender specificities. SE and MsE showed complementarity to detect SAHS, since several features from both analyses were automatically selected by the forward-selection backward-elimination algorithm. Finally, SAHS was modelled through logistic regression (LR) by using optimum sets of selected features. Modelling SAHS by genders reached significant higher performance than doing it in a jointly way. The highest diagnostic ability was reached by modelling SAHS in women. The LR classifier achieved 85.2% accuracy (Acc) and 0.951 area under the ROC curve (AROC). LR for men reached 77.6% Acc and 0.895 AROC, whereas LR for the whole OPEN ACCESSEntropy 2015, 17 124 set reached 72.3% Acc and 0.885 AROC. Our results show the usefulness of the SE and MsE analyses of HRV to detect SAHS, as well as suggest that, when using HRV, SAHS may be more accurately modelled if data are separated by gender.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Time and Frequency Domain Entropies to Detect Sleep Apnoea in Heart Rate Variability Recordings from Men and Women

Gutiérrez‐Tobal

Álvarez

Gómez‐Pilar

et al. 2015

Entropy

View full text Add to dashboard Cite

show abstract

“…The principal mechanism has been attributed to recurrent collapse of pharyngeal airway during sleep, causing intermittent blood-gas disturbance (hypercapnia and hypoxemia) and surges of sympathetic activation 11 .…”

Section: Mechanismmentioning

confidence: 99%

Sleep Apnea

Uzma

Reddy

2017

J. Gandaki Med. Coll. Nepal

View full text Add to dashboard Cite

Background: Sleep apnea is a condition that interrupts breathing while sleeping, usually caused by an obstruction blocking the back of the throat so that the air cannot reach the lungs. The brief cessation in breath automatically forces individuals to wake up and restart breathing. This can happen many times during the night, making it hard for the body to get enough oxygen, and impacts the sleep quality. It is the most common type of sleep disorder breathing.

show abstract

“…22 Obesity has also been implicated in anatomical changes that predispose patients to upper airway obstruction and reduced neuromuscular control of the air passages during sleep. 23,24 Obesity accelerates the initial onset and progression of physical disability in older adults. 25 Maternal obesity is associated with an increased risk for congenital anomalies.…”

Section: Us Endocrinologymentioning

confidence: 99%

The Role of Phentermine/Topiramate Extended-release in the Treatment of Obesity and Obesity-related Adverse Health Consequences

Gavin¹

2013

US Endocrinology

View full text Add to dashboard Cite

Obesity has traditionally been defined as a body mass index (BMI) of 30 kg/m 2 or more. However, BMI has limitations, and obesity is now defined by a number of factors, including waist circumference.1 The growing prevalence of obesity is a global health concern. In 2008, 10 % of men and 14 % of women aged 20+ were obese compared with 5 % in men and 8 % in women in 1980. 2 Obesity rates in the US are among the highest in the world: in 2009-10, more than 37 % of US adults and almost 17 % of youth were obese. 3 These trends have affected all ethnic groups, all regions of the country, and all socioeconomic groups, with the largest increases in obesity occurring among children. 4 In recognition of its underlying vasculopathic physiology, and its association with significant morbidity and mortality, the nation's largest physician group has recently categorized obesity as a disease itself rather than simply a risk factor for other metabolic diseases. The prevailing thought among many is that metabolic diseases are pathologic consequences of adiposity. 1,5 This article will discuss the health and economic burdens of obesity as well as strategies for treating the condition, with a focus on a recently approved pharmacologic agent: phentermine/topiramate extended-release (PHEN/ TPM ER). The Health and Economic Burdens of ObesityObesity contributes to adverse metabolic consequences. KeywordsObesity, phentermine, topiramate, weight loss Disclosure: James R Gavin III, MD, PhD, has served as a speaker for Vivus Pharmaceuticals and has received speaker's fees for this activity.

show abstract

Pathophysiology of Adult Obstructive Sleep Apnea

Cited by 508 publications

References 148 publications

Assessment of Time and Frequency Domain Entropies to Detect Sleep Apnoea in Heart Rate Variability Recordings from Men and Women

Assessment of Time and Frequency Domain Entropies to Detect Sleep Apnoea in Heart Rate Variability Recordings from Men and Women

Sleep Apnea

The Role of Phentermine/Topiramate Extended-release in the Treatment of Obesity and Obesity-related Adverse Health Consequences

Contact Info

Product

Resources

About