Pathophysiology of Acute Heart Failure. What’s New?

Терещенко, С. Н.; Жиров, И. В.; Nasonova, Svetlana N.; Nikolaeva, O. A.; Lediakhova, M.V.

doi:10.15829/1560-4071-2016-9-52-64

Cited by 6 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association between signifi cantly increased levels of GGT activity and sudden death from heart diseases was estimated. The prognostic value of the serological activity of gamma-glutamyl transpeptidase on fatal events in coronary heart disease and chronic heart failure was confi rmed [32,34]. The effects of GGT as a pro-oxidant are evident within atherosclerotic coronary and cerebral plaques, where the enzyme was histochemically identifi ed and retained by iron-containing proteins -transferrin, ferritin, or even free iron shown to be present in suffi cient concentrations in the atherosclerotic plaque [24].…”

Section: The Role Of Enzymes Pro-and Antioxidants In Development Of Heart Failure and Myocardial Infarctionmentioning

confidence: 99%

“…Ubiquinone may improve endothelial dysfunction, can possibly enhance cardiac ATP production and may be an adjunctive therapeutic option for patients with heart failure with reduced ejection fraction. Evidence to support its widespread use is limited by small, heterogeneous studies [34]. A-tocopherol (Vitamin E) is a naturally occurring basic fatsoluble antioxidant and stabiliser of biological membranes.…”

Section: The Role Of Fat-soluble Antioxidants In Development Of Heart Failure and Myocardial Infarctionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Oxidative Stress and Antioxidants in Occurrence of Myocardial Infarction and Chronic Heart Failure

Терехина

Goryacheva

2020

Medical University

View full text Add to dashboard Cite

Oxidative stress is one of the most important mechanisms of cardiovascular diseases, especially in heart failure. Mitochondrial dysfunction and inflammation play a major role in formation of free radicals and antioxidants. The association between oxidative stress, telomere biology and cell senescence plays the key role in cardiovascular pathology development. The paper considers role of pro-oxidant and antioxidant enzymes in heart pathology development. Specifically, the role of such antioxidant enzymes as glutathione peroxidase 3, catalase, and superoxide dismutase is described. The role of gamma-glutamyl transferase is emphasized as its activity increases significantly in cases of heart failure, coronary heart disease, stroke, arterial hypertensions, and arrhythmias. This article is a literature review of the effect of such antioxidants as alpha-tocopherol, ubiquinone, uric acid, and triiodothyronine on development of heart failure and myocardial infarction. A decrease in triiodothyronine concentration is a risk factor for coronary heart disease. High uric acid values in patients with myocardial infarction upon admission to the hospital are associated with a high risk of sudden death. The influence of such minerals such as zinc, copper, magnesium, selenium, potassium, sodium, calcium, and iron on heart failure development has been analyzed. The role of ceruloplasmin as an independent predictor of acute and chronic cardiac disorders cardiac events, mortality, and bad prognosis in patients with heart failure and myocardial infarction is examined. The authors demonstrate the influence of inflammation on heart failure development as well as association of inflammation with oxidative stress.

show abstract

Section: The Role Of Enzymes Pro-and Antioxidants In Development Of Heart Failure and Myocardial Infarctionmentioning

confidence: 99%

Section: The Role Of Fat-soluble Antioxidants In Development Of Heart Failure and Myocardial Infarctionmentioning

confidence: 99%

The Role of Oxidative Stress and Antioxidants in Occurrence of Myocardial Infarction and Chronic Heart Failure

Терехина

Goryacheva

2020

Medical University

View full text Add to dashboard Cite

show abstract

“…Предполагается, что в роли активаторов аноиксиса могут выступать некоторые профиброгенные биологические агенты и провоспалительные цитокины, а одним их возможных механизмов реализации может выступать оксидативный стресс [26]. Таким образом, наряду с нейрогуморальным и гемодинамическим эффектами миокардиального фиброза, в формировании ХСН могут принимать участие и механизмы клеточной дезадаптации [27].…”

Section: нарушение кровоснабжения миокардаunclassified

Role of the cardiac extracellular matrix in the onset and progression of heart failure

et al. 2021

View full text Add to dashboard Cite

Any cardiovascular disease leads to heart failure (HF) — a complex clinical syndrome, the course of which is probably specified by the influence of cardiovascular factors on cardiac extracellular matrix (ECM).The presented literature data indicate that the cardiac ECM is an important pathophysiological link in the onset and progression of HF. The morphological and electrical remodeling negatively affects the systolic and diastolic functions of the heart. Impaired myocardial blood delivery, cellular maladaptation, atrial and ventricular arrhythmias are additional mechanisms of the influence of myocardial fibrosis on HF course.Understanding this role of ECM and the development of algorithms for verifying the individual status of ECM in cardiovascular patients can provide additional data on the course of HF, help to assess the risk of adverse cardiovascular events and effectively control the ongoing pharmacological and non-drug therapy.

show abstract

“…Nevertheless, the possibility that electroporation may be more likely induced in failing myocardium cannot be excluded. A study in patients with structural heart disease, HF, and implanted ICD for primary and secondary prevention of sudden cardiac death found that the instantaneous emergence of local injury current on intracardiac right ventricular electrograms, which was probably caused by electroporation, during defibrillation threshold testing was a predictor of HF hospitalization and death [26]. Moreover, the local injury current has recently been shown to appear after spontaneous appropriate and inappropriate ICD shocks in some individuals [13].…”

Section: Adverse Effects Of Shocksmentioning

confidence: 99%

Molecular mechanisms of heart failure progression associated with implantable cardioverter‐defibrillator shocks for ventricular tachyarrhythmias

Tsuji

Ishikawa

Makita

2014

Journal of Arrhythmia

View full text Add to dashboard Cite

Implantable cardioverter‐defibrillators (ICDs) are highly effective in reducing mortality related to ventricular tachyarrhythmias (VTAs). Despite this benefit, the occurrence of ICD shocks for VTAs in patients with heart failure (HF) and depressed left ventricular function has been associated with adverse outcomes. Patients with shocked VTAs are at an elevated risk of HF and death. While VTAs may be markers for high‐risk patients, it is possible that the harmful effects of electrical shocks and VTAs are involved in HF progression and associated mortality. Some investigators have speculated that shocked VTAs may activate signaling pathways in the molecular cascade of HF. We recently reported in an experimental model of ventricular fibrillation storm that multiple ICD shocks for recurrent ventricular fibrillation caused striking activation of Ca2+/calmodulin‐dependent protein kinase II, a validated signaling molecule for HF. This review article describes the harmful effects of shocks and VTAs and proposes that Ca2+/calmodulin‐dependent protein kinase II could connect shocked VTAs to adverse outcomes.

show abstract

Pathophysiology of Acute Heart Failure. What’s New?

Cited by 6 publications

References 23 publications

The Role of Oxidative Stress and Antioxidants in Occurrence of Myocardial Infarction and Chronic Heart Failure

The Role of Oxidative Stress and Antioxidants in Occurrence of Myocardial Infarction and Chronic Heart Failure

Role of the cardiac extracellular matrix in the onset and progression of heart failure

Molecular mechanisms of heart failure progression associated with implantable cardioverter‐defibrillator shocks for ventricular tachyarrhythmias

Contact Info

Product

Resources

About