Pathophysiology and Treatment of Brain AVMs*

Grzyska, Ulrich; Fiehler, Jens

doi:10.1007/s00062-009-8035-y

Cited by 13 publications

(13 citation statements)

References 46 publications

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“…[9] Gryzska and Fiehler added that compartments are in hemodynamic balance as there was no transfer of contrast material observed from one compartment to another in digital subtraction angiography. [11] This latter finding supports Kakizawa et al . 's finding on 3D rotational angiography that nidal compartments are independently fed and do not overlap.…”

Section: Introductionsupporting

confidence: 83%

“…As there are more compartments in the model, the less blood flows into the brain, possibly demonstrating in these models the “steal” phenomenon that has been described in angiographic studies. [611]…”

Section: Resultsmentioning

confidence: 99%

“…This is based on Yamada et al 's anatomic study on brain AVMs. [1011] Each compartment is composed of a series of resistors to represent the pressure gradient along the AVM from the arterial (N1), arteriolar (N2), venular (N3), and venous (N4) ends of the AVMs, akin to the “channels” in Dr. Guglielmi's work. [13] The compartment drains to a common draining vein with a 95 ohm resistance which eventually drains to the Transverse Sinus- Jugular vein output, set at 18 ohms.…”

Section: Methodsmentioning

confidence: 99%

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AVM Compartments: Do they modulate trasnidal pressures? An electrical network analysis

2012

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Background:Arteriovenous malformation (AVM) compartments are thought as independently fed, hemodynamically independent components of the AVM nidus. Its possible role in modulating transnidal pressures have not been investigated to our knowledge.Objective:To investigate if AVM compartments play a role in modulating transnidal pressures by using electrical models as a method of investigation.Materials and Methods:Monocompartmental and multicompartmental AVM models were constructed using electrical circuits- building on Dr. Guglielmi's previous work. Each compartment was fed by two feeding arteries (resistors) and had a shared draining vein with other compartments in the AVM nidus. Each compartment is composed of a series of resistors which represents the pressure gradient along the AVM (arterial, arteriolar, venular, and venous). Pressure (voltage) readings were obtained within these nidal points.Results:The pressure gradient (venous-arterial) is more as there are less AVM compartments in the nidus model. The monocomparmental model had a pressure gradient of 66mmHg (V); while it was 64, 61, and 59 for the 2-, 3-, and 4-compartment models, respectively. In addition, the more the number of compartments, the greater the flow (mA) is in the whole AVM nidus, 33 ml/min for the monocompartmental AVM and 121ml/min for the 4-compartment AVM; though there was greater flow per compartment as there were less compartments, 33ml/min per compartment for the monocompartmental model versus 29ml/min for the 4-compartment model.Conclusion:Transnidal pressure gradients may be less the more compartments an AVM has. This electrical model represents an approach that can be used in investigating the hemodynamic contributions of AVM compartments.

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Section: Introductionsupporting

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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AVM Compartments: Do they modulate trasnidal pressures? An electrical network analysis

2012

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“…The challenge is to have more knowledge about AVM like about aneurysm if they will bleed or not, or how the development in time will be and to observe them with the current imaging modalities, which had a tremendous development in comparison to these ones of our first part, almost just angiography and later on axial computed tomography 10 .…”

Section: Discussion Of Patients With Avmfmentioning

confidence: 99%

Intracranial Aneurysms and Vascular Malformations: Diagnosis for Therapy

Grobovschek

Himmer²,

Wolfsgruber³

et al. 2011

Neuroradiol J

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In the second part of our overviewstudy the diagnosis for the treatment of our patients with intracranial vascular malformations (aneurysms / AVMF - arteriovenous malformations) is again shown in a region of about 500.000 inhabitants and just an overview of the outcome. This second part will be an overall comparison between the former diagnostic for the treatment and the here described diagnostic for the treatment (CTA, MRA, DSA rot / microsurgery, endovascular interventional techniques etc.), concerning also the topography and the demography. The future trends are also outlined.

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“…The prevalence of this condition is 0.01%–0.5% of the population with presentation common in children and young adults [ 2 , 6 ]. In addition to haemorrhage, AVMs can present with epileptic seizures, chronic headaches, migraines and ischaemic neurologic deficits [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Animal Models of Arteriovenous Malformation: A Review

Raj

Stoodley

2015

Veterinary Sciences

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Arteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated safely and effectively with existing options. Several animal models have been developed with the aims of understanding AVM pathophysiology and improving treatment. No animal model perfectly mimics a human AVM. Each model has limitations and advantages. Models contribute to the understanding of AVMs and hopefully to the development of improved therapies. This paper reviews animal models of AVMs and their advantages and disadvantages.

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Pathophysiology and Treatment of Brain AVMs*

Cited by 13 publications

References 46 publications

AVM Compartments: Do they modulate trasnidal pressures? An electrical network analysis

AVM Compartments: Do they modulate trasnidal pressures? An electrical network analysis

Intracranial Aneurysms and Vascular Malformations: Diagnosis for Therapy

Experimental Animal Models of Arteriovenous Malformation: A Review

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