Pathophysiology and modern treatment of ulcer disease (Review)

Holle, G

doi:10.3892/ijmm_00000368

Cited by 23 publications

(19 citation statements)

References 32 publications

(39 reference statements)

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“…We suggest that impaired gastric emptying related to declining renal function may explain this phenomenon [26]. Accelerated gastric emptying contributes to the risk of DU [27]; therefore, impaired gastric emptying related to uremia may damage gastric mucosa and increase the risk of GU [26], [27].…”

Section: Discussionmentioning

confidence: 88%

Peptic Ulcer Disease Risk in Chronic Kidney Disease: Ten-Year Incidence, Ulcer Location, and Ulcerogenic Effect of Medications

et al. 2014

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ObjectivesWe aimed at determining peptic ulcer disease (PUD) incidence among chronic kidney disease (CKD) patients during 1998–2008, compared to patients without CKD, and at examining associations between CKD and PUD.MethodsData for 1998–2008 were extracted from the National Health Insurance Research Database in Taiwan. The annual PUD incidence (cases per thousand persons per year) was calculated separately for patients with and without CKD. Characteristics of patients with newly diagnosed PUD (n = 16322) were compared to those of a control group without PUD (n = 32644). The 2 groups were matched for age, sex, and index year. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression.ResultsOver the 10-year period, the PUD incidence was ∼10–12 times higher in CKD patients than in those without CKD. Its incidence in elderly CKD patients increased rapidly over time. For CKD patients, most PUD events (>95%) were managed during hospitalization. Peptic ulcer risk, adjusted for all potential confounders, was much higher in CKD patients undergoing hemodialysis (adjusted OR, 9.74; 95% CI, 7.11–13.31). Maintenance hemodialysis patients were 2 times more likely to have gastric ulcers than duodenal ulcers, while CKD patients not on dialysis had similar risks for both. There were no significant interactions between medications and CKD status on the peptic ulcer risk. Unlike CKD patients on nonsteroidal anti-inflammatory drugs and clopidogrel, those on aspirin did not have a higher peptic ulcer risk (adjusted OR, 0.88; 95% CI, 0.44–1.77).ConclusionsCKD patients have a substantially increased PUD risk, and the majority of CKD patients with PUD require hospital management. Further, peptic ulcer risk is affected by hemodialysis therapy, patient status (inpatient vs. outpatient), and ulcerogenic medications.

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Section: Discussionmentioning

confidence: 88%

Peptic Ulcer Disease Risk in Chronic Kidney Disease: Ten-Year Incidence, Ulcer Location, and Ulcerogenic Effect of Medications

et al. 2014

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“…There have recently been extraordinary advances in the understanding of the pathophysiology and treatment of PU [1][2][3] . It is generally accepted that it results from an imbalance between gastric aggressive factors and maintenance of the mucosal integrity through an endogenous defense mechanism [5] .…”

Section: Discussionmentioning

confidence: 99%

“…Peptic ulcer (PU) is one of the most common gastrointestinal disorders [1][2][3] . The goals of treatment for PU are to relieve pain, enhance ulcer healing, prevent complications, and prevent ulcer recurrence.…”

Section: Introductionmentioning

confidence: 99%

Antacid effects of Chinese herbal prescriptions assessed by a modified artificial stomach model

Chen²,

Chen³

2010

WJG

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“…Even in recent times we benefit from this knowledge 63. Especially bariatric surgery which focuses increasingly on the stomach as target organ obtains valuable information based on already discovered relations.…”

Section: Discussionmentioning

confidence: 99%

From Longitudinal Gastric Resection to Sleeve Gastrectomy—Revival of a Previously Established Surgical Procedure

Spiegel

Skawran

2011

Journal of Gastrointestinal Surgery

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IntroductionSleeve gastrectomy is becoming increasingly popular within bariatric surgery. Initially introduced as a component of complex interventions and later as part of a two-stage operation in high-risk patients, the procedure is now more common as one-stage operation and subject of avid scientific discussion. However, the concept of longitudinal gastric resection is not new. The procedure was already established in ulcer surgery but soon faded into insignificance. This article aims to trace the historical development of resection of the greater curvature with particular reference to its origin in ulcer and bariatric surgery. The contribution of ulcer surgery to modern sleeve gastrectomy is highlighted. Furthermore, the current value of sleeve gastrectomy within the spectrum of bariatric surgical procedures will be discussed. Relevant medical literature from PubMed to April 2010 was reviewed.DiscussionBesides bariatric surgery modern sleeve gastrectomy has one more so far largely neglected origin: segmental and later longitudinal gastric resection used in ulcer surgery. Experience and achievements from ulcer surgery simplified and facilitated development of sleeve gastrectomy which is not the desired universal procedure for bariatric surgery but certainly an attractive treatment option. It should be performed in a more standardized manner and with due regard to future long-term results.

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Pathophysiology and modern treatment of ulcer disease (Review)

Cited by 23 publications

References 32 publications

Peptic Ulcer Disease Risk in Chronic Kidney Disease: Ten-Year Incidence, Ulcer Location, and Ulcerogenic Effect of Medications

Peptic Ulcer Disease Risk in Chronic Kidney Disease: Ten-Year Incidence, Ulcer Location, and Ulcerogenic Effect of Medications

Antacid effects of Chinese herbal prescriptions assessed by a modified artificial stomach model

From Longitudinal Gastric Resection to Sleeve Gastrectomy—Revival of a Previously Established Surgical Procedure

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