Pathophysiology and Clinical Spectrum of Infections in Systemic Lupus Erythematosus

Cuchacovich, Raquel; Gedalia, Abraham

doi:10.1016/j.rdc.2009.03.003

Cited by 99 publications

(81 citation statements)

References 131 publications

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“…Approximately 80% of infections are caused by pathogenic bacteria [27]. However, the presence of clinical symptoms and serological manifestations can mimic SLE.…”

Section: Discussionmentioning

confidence: 99%

Post-delivery mycobacterium tuberculosis infection misdiagnosed as systemic lupus erythematosus

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Shrestha

et al. 2016

J Infect Dev Ctries

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Tuberculosis is a common infectious mycobacterial disease having a wide range of clinical and serological manifestations that are similar to rheumatic disease. Differential diagnosis is a crucial aspect in any rheumatic disease as many other infectious diseases portray clinical similarities and autoantibody positivity. Our case report illustrates of a young woman just after the delivery of a child presented an unusual case of extrapulmonary tuberculosis infection initially misdiagnosed as systemic lupus erythematosus (SLE).

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“…Approximately 80% of infections are caused by pathogenic bacteria [27]. However, the presence of clinical symptoms and serological manifestations can mimic SLE.…”

Section: Discussionmentioning

confidence: 99%

Post-delivery mycobacterium tuberculosis infection misdiagnosed as systemic lupus erythematosus

Ting

Shrestha

et al. 2016

J Infect Dev Ctries

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“…Cases of SLE with fungaemia or invasive fungal infection are rare but life-threatening conditions in SLE [36]. Severe Candida infection is the most frequently identified opportunistic fungal infection in several SLE series, associated with steroid and cytotoxic drug therapy [37]. Nocardial infections have been also described in steroid-treated SLE patients, and pneumonia and brain abscess are the most frequent clinical presentations [38] and [39].…”

Section: Opportunistic Infectionsmentioning

confidence: 99%

“…Taken together, all the studies stressed that active lupus disease (SLEDAI > 7) is probably the main risk factor for opportunistic infection. It is noteworthy to remember that low prednisolone doses before fungal infection or high prednisolone doses following fungal infection are associated with higher mortality [37].…”

Section: Opportunistic Infectionsmentioning

confidence: 99%

“…The most commonly reported viral infections in patients who have SLE are parvovirus B19 (HPV-B19) (there are more than 30 reports of primary B19 infection reported as lupus-like syndrome) [37] and cytomegalovirus (CMV) (predominantly presenting in severely immunosuppressed patients). It is not among the purposes of this review to analysis the causative role of virus in the pathogenesis of SLE.…”

Section: Viral Infectionsmentioning

confidence: 99%

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Management of infection in systemic lupus erythematosus

Sciascia

Cuadrado

Karim

2013

Best Practice & Research Clinical Rheumatology

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal autoantibody production and clearance. This immunological background has been suggested to play a role in the susceptibility of SLE patients to infection. Moreover, drugs (most of them immunosuppressive or immunomodulating agents) used in the treatment of moderate and severe lupus give rise to a tendency for infections, including opportunistic ones. Infections may mimic the exacerbations of SLE, leading to confusion over the diagnosis and appropriate treatment. Despite increased awareness of this problem, infections remain a major source of morbidity and mortality in SLE. There are various strategies which can be applied to try and reduce the risk of infection in SLE patients. Options include vaccinations, antibiotic/antiviral prophylaxis and intravenous immunoglobulins.

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“…Infections as a consequence of Mycobacterium species are of two groups: infections due to M tuberculosis, that trend to occur early in the course of lupus, related to disease activity and treatment, and usually resulting mainly from reactivation of latent infection or to reinfection; and infections to non-tuberculous Mycobacterium (NTM), presenting later in the course of disease and predominantly as a new infection, including M. avium complex, M. chelonae, M. haemophilum or M. fortitum (Cuchacovich & Gedalia, 2009). Mok et al (M.Y.…”

Section: Infections Due To Mycobacteriamentioning

confidence: 99%