2016
DOI: 10.1097/cnq.0000000000000102
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Pathophysiology and Classification of Respiratory Failure

Abstract: Respiratory failure is a condition in which the respiratory system fails in one or both of its gas exchange functions. It is a major cause of morbidity and mortality in patients admitted to intensive care units. It is a result of either lung failure, resulting in hypoxemia, or pump failure, resulting in alveolar hypoventilation and hypercapnia. This article covers the basic lung anatomy, pathophysiology, and classification of respiratory failure.

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Cited by 34 publications
(20 citation statements)
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“…In the research on the approach of severe care of respiratory system failure, many scholars at home and abroad have studied it and achieved certain research results. Some scholars pointed out that the rational use of ventilator, active and effective treatment, and nursing can effectively control the symptoms of patients, increase exercise endurance, reduce the occurrence of complications, reduce the number of hospitalizations, and prolong the life of patients [11]. Other scholars have pointed out that the complications of respiratory failure are closely related to the time of receiving ventilator treatment and the difficulty of weaning, and the consequences are increased mortality, increased costs, and decreased quality of life [12].…”
Section: Introductionmentioning
confidence: 99%
“…In the research on the approach of severe care of respiratory system failure, many scholars at home and abroad have studied it and achieved certain research results. Some scholars pointed out that the rational use of ventilator, active and effective treatment, and nursing can effectively control the symptoms of patients, increase exercise endurance, reduce the occurrence of complications, reduce the number of hospitalizations, and prolong the life of patients [11]. Other scholars have pointed out that the complications of respiratory failure are closely related to the time of receiving ventilator treatment and the difficulty of weaning, and the consequences are increased mortality, increased costs, and decreased quality of life [12].…”
Section: Introductionmentioning
confidence: 99%
“…Mild CO 2 retention and hypoxemia may also lead to cognitive effects and reduce responsiveness ( 32 ). A small decrease in oxygen stimulates the sympathetic nervous system, resulting in a faster heart rate ( 33 ). The increase in respiratory resistance caused by masks leads to an increase in respiratory muscle work and intrathoracic negative pressure, increases cardiopulmonary oxygen consumption, significantly increases heart rate, and further leads to physical discomfort and increased pressure ( 34 ).…”
Section: Discussionmentioning
confidence: 99%
“…The onset of respiratory failure may be acute or chronic, and the appearance of compensation mechanisms is possible if the onset is carried out more gradually [13]. The diagnosis of respiratory failure is made by arterial blood gas and, according to CO 2 levels, it is classified as type I (without hypercapnia) or type II (with hypercapnia) (Table 3) [14].…”
Section: Hypoxemia and Respiratory Insufficiencymentioning
confidence: 99%