Pathophysiology and Associations of Underactive Bladder

Andersson, Karl‐Erik

doi:10.1007/978-3-319-43087-4_1

Cited by 2 publications

(3 citation statements)

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“…Burney et al performed urodynamic evaluations in 60 stroke patients, during the acute phase, and reported that 47% had urinary retention, mostly due to detrusor areflexia (75%) from the initial cerebral shock. Nonetheless, DO constitutes the most common long‐term functional bladder dysfunction after stroke …”

Section: Resultsmentioning

confidence: 99%

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Pathophysiological mechanisms in detrusor underactivity: Novel experimental findings

Vale

Jesus

Marcelissen

et al. 2019

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Underactive bladder (UAB) is a multifactorial symptom complex often related to detrusor underactivity (DU). Although recognized as a common cause of lower urinary tract symptoms and with significant effects on quality of life, UAB/DU is largely underresearched. Herein, we review upto-date knowledge on the pathophysiological mechanisms of UAB/DU, with an emphasis on the relationship between UAB and bladder outlet obstruction (BOO). Original articles and reviews concerning UAB/DU were identified through a search of the PubMed/Medline and Scopus databases. DU can result from several pathological mechanisms, which can be categorized as idiopathic, neurogenic, myogenic, or functional. The main etiological factors of UAB/DU are aging, diabetes mellitus, neurogenic disorders, and BOO. Although conventional models focus primarily on efferent nerve and myogenic mechanisms, contemporary views highlight the importance of the afferent pathway. Specifically, recent findings in BOO showed that afferent dysfunction, such as altered expression of muscarinic and purinergic P2X 3 receptors or diminished urothelial ATP may play a role in the initial and reversible stages of DU, with potential diagnostic and therapeutic implications. K E Y W O R D S bladder outlet obstruction, detrusor underactivity, lower urinary tract symptoms, pathophysiology

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Section: Resultsmentioning

confidence: 99%

“…The underlying pathophysiology of DU in PD is incompletely understood, but is thought to result from an impaired frontal–basal ganglia circuit . PD can be induced in monkeys by administration of a neurotoxin selective for dopaminergic neurons in the substantia nigra (ie, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine [MPTP]).…”

Section: Resultsmentioning

confidence: 99%

Pathophysiological mechanisms in detrusor underactivity: Novel experimental findings

Vale

Jesus

Marcelissen

et al. 2019

LUTS

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show abstract

“…As is typical of many urological, kidney-related, and other organbased disorders, DUA and UAB have complex multimodel pathophysiology that is difficult to diagnose and mostly poorly understood, which also frequently involves direct or indirect contributions from other diverse disorders. This includes other urological disorders such as bladder outflow obstruction (BOO) as well as neurogenic disorders, diabetes, and other metabolic conditions and aging (1).…”

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confidence: 99%

Stimulating bioelectronic medicine discovery for urological disorders

Osborne

2017

American Journal of Physiology-Renal Physiology

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Pathophysiology and Associations of Underactive Bladder

Cited by 2 publications

References 80 publications

Pathophysiological mechanisms in detrusor underactivity: Novel experimental findings

Pathophysiological mechanisms in detrusor underactivity: Novel experimental findings

Stimulating bioelectronic medicine discovery for urological disorders

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