Pathophysiological study of atorvastatin drug on toxicity induced by D-galactose in liver of experimental rats

Abstract

Background: This study was designed to clarify the toxic effect of a high dose of atorvastatin and the palliative effect of low doses of atorvastatin on toxicity induced by D-galactose in the liver, kidney, and adrenal gland organs. The current study was conducted on 36 healthy adult male Wistar albino rats (Rattus norvegicus) who were sexually mature at the age of 8-10 weeks and weighed between 200 and 250 grams in the animal house of Pharmacy College/ Basrah University. Methods: These rats were selected and divided into six main groups of equal weight, each with six rats. The first group (control) was drenched in (1) mL of normal saline. The second group was drenched in a single dose of atorvastatin (150 mg per kg B.W), the third received D-galactose at a dose of (500 mg per kg B.W), and the fourth group was treated with both D-galactose and atorvastatin (10 mg per kg B.W), the fifth group was coadministered with both D-galactose and atorvastatin (20 mg per kg B.W), and the sixth group where rats cotreated with Dgalactose and atorvastatin (40 mg per kg B.W). The treatment was extended for 8 weeks.