Pathophysiological studies on Dicrocoelium dendriticum infection in sheep

Theodoridis, Y.; Duncan, J.L.; Maclean, John; Himonas, C.

doi:10.1016/0304-4017(91)90062-z

Cited by 26 publications

(19 citation statements)

References 7 publications

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“…The lack of change in the total protein values and the slight increase in albumin levels observed by us coincides with results obtained by Theodoridis et al (1991), who considered that worm burdens of up to 4000 D. dendriticum do not cause significant blood or plasma protein loss in naturally infected sheep. However, Gundlach et al (1982) obtained an increase in both parameters, Petrov & Abalikhin (1983) in the proteins up to 4% in lambs infected with 2600 metacercariae, and Scala et al (1991) in albumin in sheep naturally infected with 16 -828 D. dendriticum.…”

Section: Discussionsupporting

confidence: 73%

Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliasis in northern Spain

Manga-González

González-Lanza

2005

J. Helminthol.

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Section: Discussionsupporting

confidence: 73%

Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliasis in northern Spain

Manga-González

González-Lanza

2005

J. Helminthol.

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“…The lack of alteration in the total protein values and the scant increase in those of albumin coincides with the findings by Theodoridis et al (1991), who considered that burdens of up to 4,000 D. dendriticum worms do not cause significant blood or plasma protein loss in naturally infected sheep. However, Gundlach et al (1982) obtained an increase in both parameters, Petrov and Abalikhin (1983) in the proteins up to 4% 60 days p.i.…”

Section: Discussionsupporting

confidence: 72%

Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum (Digenea)

et al. 2004

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Hepatic enzymes and biochemical parameter values were analysed in the sera of 32 lambs: 12 infected with 1,000 Dicrocoelium dendriticum metacercariae, 12 with 3,000 and eight controls. Blood samples were collected at intervals of 30 days from day 0 post-infection (p.i.). Half the lambs in each group were slaughtered on days 60 and 180 p.i, respectively. A histopathological and ultrastructural study was carried out on the liver, gall bladder and hepatic lymph nodes of all animals. A minute increase was detected in the bilirubin (7%) and albumin (3%) values in the infected lambs (with 30-2,063 worms) in comparison with those of the controls. The hepatic enzyme values did increase, above all aspartate aminotransferase (19%) and alanine aminotransferase (22%), mainly in the lambs tested with 3,000 metacercariae (38% and 48%, respectively). The increase was significant 60 days p.i. The severity of the lesions was closely associated with the parasite burden.

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“…Dicrocoelium dendriticum, the lancet¯uke, has a worldwide geographical distribution and parasitizes the liver of many species of animals and that of humans (Mohamed and Mummery 1990; Theodoridis et al 1991). It has been reported in a wide range of hosts from all European countries, including the British Isles and Spain; from a number of localities in Eastern Europe; from China, Japan, Canada, and the Indo-Malayan and neotropical regions; and from the United States (Steele 1982).…”

Section: Introductionmentioning

confidence: 99%

“…After the acute stage a chronic inammation of the biliary ducts with a marked proliferation of connective tissue develops (Alzieu and Ducos de Lahitte 1991). Clinical manifestations of acute or chronic dicroceliosis are observed primarily in sheep, goats, and cattle, causing important economic losses due to liver condemnation (Theodoridis et al 1991). Additionally, in areas where infection coexists with fasciolosis the importance of this parasitosis has increased due to the antihelmintic treatments used against Fasciola hepatica (Rojo-VaÂ zquez et al 1981).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and changes in liver antioxidant enzymes induced by experimental dicroceliosis in hamsters

Sánchez-Campos¹,

Tuñón²,

González³

et al. 1999

Parasitology Research

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The purpose of our study was to assess the effects of experimental dicroceliosis on the antioxidant defense capability of the liver in hamsters. Studies were carried out at 80 and 120 days after infection with an oral dose of 40 metacercariae of Dicrocoelium dendriticum. The parasitic pathology was ascertained by the presence of fluke eggs in feces, increased serum ALT and AST activities, and histological findings. The concentration of thiobarbituric acid-reactive substances (TBARS) and the ratio of oxidized to reduced glutathione (GSSG/GSH), measured as markers of oxidative stress, were significantly increased [TBARS: +40% and +84% at 80 and 120 days postinfection (p.i.), respectively; GSSG/GSH: +200% and +117%]. Dicroceliosis increased Se-dependent glutathione peroxidase (GPx) activity in both cytosol (+24% and +46%) and mitochondria (+73% and +41%). Superoxide dismutase activity was significantly reduced in cytosol (-19% and -38%) and mitochondria (-20% and -39%). No significant change was found in the activity of Se-independent GPx or catalase. The ratio of glutathione peroxidase/glutathione reductase at 80 and 120 days p.i. was increased by 25% and 63%, respectively. Gamma-glutamyl cysteinyl synthetase activity was increased by 27% and 20%, respectively. Our data indicate that although dicroceliosis courses with activation of antioxidant enzymes and glutathione synthesis, inefficient scavenging of reactive oxygen species takes place, resulting in oxidative liver damage.

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Pathophysiological studies on Dicrocoelium dendriticum infection in sheep

Cited by 26 publications

References 7 publications

Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliasis in northern Spain

Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliasis in northern Spain

Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum (Digenea)

Oxidative stress and changes in liver antioxidant enzymes induced by experimental dicroceliosis in hamsters

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